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20,252 grants found
Showing 18,941 – 18,960 of 20,252 grants
Investigating the Role of Cdc73 in T-cell Acute Lymphoblastic Leukemia (T-ALL)
PROJECT SUMMARY About 60% of T-cell acute lymphoblastic leukemia (T-ALL) patients have activating NOTCH1 mutations, making NOTCH1 the most prevalent oncogene in this cancer. In ear...
Advanced Surgical Pathology Device
Each year, millions of Americans are diagnosed with skin cancer. The treatment with the highest cure rate and best functional and cosmetic outcomes is Mohs Surgery.Mohs depends on...
Investigating the Role of Cdc73 in T-cell Acute Lymphoblastic Leukemia (T-ALL)
PROJECT SUMMARY About 60% of T-cell acute lymphoblastic leukemia (T-ALL) patients have activating NOTCH1 mutations, making NOTCH1 the most prevalent oncogene in this cancer.In earl...
Cancer Epidemiology Cohort in Male Health Professionals
Project Summary/Abstract Prostate cancer is the most common cancer and the second most common cause of cancer death in U.S. men. Over 3 million men are currently living with prosta...
Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health
PROJECT SUMMARY The supplement will add measures to the AMPLIFI P01 (abbreviated summary below) & enhance its contribution to the ADOPT Consortium. By 2020, the number of US ca...
Suppressing oncogenic RNA regulons using engineered zinc finger ribonucleases
Gene expression is extensively reprogrammed in cancer.These dysregulated genes include subpopulations called RNA regulons that are coordinately regulated by posttranscriptional mec...
Mechanisms of liver metastasis and associated resistance to immunotherapy
PROJECT SUMMARY The incidence of melanoma has doubled in the last three decades and is projected to exceed 100,000 cases in the US in 2020. Almost 7,000 people died of melanoma in...
SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children with Cancer
PROJECT SUMMARY/ABSTRACT Childhood cancer leads to extended disruptions within family systems, which can leave siblings feeling disconnected from their families and left to cope wi...
Targeting ATM to boost systemic effects of radiotherapy and immunotherapy
PROJECT SUMMARY Immune checkpoint blockade (ICB) therapy has shown great promise in cancer treatment recently. However, currently only a minority of patients could benefit from imm...
Mechanisms of liver metastasis and associated resistance to immunotherapy
PROJECT SUMMARY The incidence of melanoma has doubled in the last three decades and is projected to exceed 100,000 cases in the US in 2020. Almost 7,000 people died of melanoma in...
Targeting ATM to boost systemic effects of radiotherapy and immunotherapy
PROJECT SUMMARY Immune checkpoint blockade (ICB) therapy has shown great promise in cancer treatment recently. However, currently only a minority of patients could benefit from imm...
SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children with Cancer
PROJECT SUMMARY/ABSTRACT Childhood cancer leads to extended disruptions within family systems, which can leave siblings feeling disconnected from their families and left to cope wi...
Suppressing oncogenic RNA regulons using engineered zinc finger ribonucleases
Gene expression is extensively reprogrammed in cancer. These dysregulated genes include subpopulations called RNA regulons that are coordinately regulated by posttranscriptional me...
Suppressing oncogenic RNA regulons using engineered zinc finger ribonucleases
Gene expression is extensively reprogrammed in cancer. These dysregulated genes include subpopulations called RNA regulons that are coordinately regulated by posttranscriptional me...
Targeting ATM to boost systemic effects of radiotherapy and immunotherapy
PROJECT SUMMARY Immune checkpoint blockade (ICB) therapy has shown great promise in cancer treatment recently. However, currently only a minority of patients could benefit from imm...
Mechanisms of liver metastasis and associated resistance to immunotherapy
PROJECT SUMMARY The incidence of melanoma has doubled in the last three decades and is projected to exceed 100,000 cases in the US in 2020. Almost 7,000 people died of melanoma in...
Mechanisms of liver metastasis and associated resistance to immunotherapy
PROJECT SUMMARY The incidence of melanoma has doubled in the last three decades and is projected to exceed 100,000 cases in the US in 2020. Almost 7,000 people died of melanoma in...
Targeting ATM to boost systemic effects of radiotherapy and immunotherapy
PROJECT SUMMARY Immune checkpoint blockade (ICB) therapy has shown great promise in cancer treatment recently. However, currently only a minority of patients could benefit from imm...
Mechanisms of liver metastasis and associated resistance to immunotherapy
PROJECT SUMMARY The incidence of melanoma has doubled in the last three decades and is projected to exceed 100,000 cases in the US in 2020. Almost 7,000 people died of melanoma in...
Mechanisms of liver metastasis and associated resistance to immunotherapy
PROJECT SUMMARY Cancer immunotherapies have revolutionized the therapy of many cancers, including metastatic melanoma and clear cell renal cell carcinoma (ccRCC). Dating back 30-ye...