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20,252 grants found
Showing 18,921 – 18,940 of 20,252 grants
Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy
Abstract Radiotherapy is used to treat 60% of the cancer patients and 40% of curative cases. However, normal tissue toxicities still prevent radiotherapy from achieving more effect...
Development of B-cell-based vaccine for Glioblastoma
PROJECT SUMMARY/ABSTRACT Immunotherapy has revolutionized the treatment of many tumors. However, most GBM patients have not, so far, benefited from immunotherapeutic treatment. Wit...
Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy
Abstract Radiotherapy is used to treat 60% of the cancer patients and 40% of curative cases. However, normal tissue toxicities still prevent radiotherapy from achieving more effect...
Development of B-cell-based vaccine for Glioblastoma
PROJECT SUMMARY/ABSTRACT Immunotherapy has revolutionized the treatment of many tumors. However, most GBM patients have not, so far, benefited from immunotherapeutic treatment. Wit...
Optimizing Tobacco Treatment Delivery for People Living with HIV
With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, and are less likely to die from...
Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy
Abstract Radiotherapy is used to treat 60% of the cancer patients and 40% of curative cases. However, normal tissue toxicities still prevent radiotherapy from achieving more effect...
Optimizing Tobacco Treatment Delivery for People Living with HIV
With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, and are less likely to die from...
Investigating sliding clamps and their contribution to genome stability
Project Summary All cells must replicate their genome once per cell cycle.To ensure proper duplication, cells integrate hundreds of factors that copy, surveil, and repair our genet...
Investigating sliding clamps and their contribution to genome stability
Project Summary All cells must replicate their genome once per cell cycle. To ensure proper duplication, cells integrate hundreds of factors that copy, surveil, and repair our gene...
Investigating sliding clamps and their contribution to genome stability
Project Summary All cells must replicate their genome once per cell cycle. To ensure proper duplication, cells integrate hundreds of factors that copy, surveil, and repair our gene...
Elucidating the role of the noncoding genome in neuroblastoma
Project Summary Neuroblastoma (NB) remains one of the deadliest childhood cancers.NB exhibits a paucity of recurrent protein coding mutations and few targetable mutations (2-5), pr...
P30 Administrative Supplement to Cancer Center Support Grant to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators of the National Outreach Network.
Abstract: Please see the Research plan, as the FOA specified to put the abstract in this section.
Elucidating the role of the noncoding genome in neuroblastoma
Project Summary Neuroblastoma (NB) remains one of the deadliest childhood cancers. NB exhibits a paucity of recurrent protein coding mutations and few targetable mutations (2-5), p...
Elucidating the role of the noncoding genome in neuroblastoma
Project Summary Neuroblastoma (NB) remains one of the deadliest childhood cancers. NB exhibits a paucity of recurrent protein coding mutations and few targetable mutations (2-5), p...
Elucidating the role of the noncoding genome in neuroblastoma
Project Summary Neuroblastoma (NB) remains one of the deadliest childhood cancers. NB exhibits a paucity of recurrent protein coding mutations and few targetable mutations (2-5), p...
Preventing Myeloma Relapse after Autologous Stem Cell Transplantation with Decoy Resistant IL-18
PROJECT SUMMARY/ABSTRACT Multiple myeloma is the second most common hematological malignancy and despite improved patient outcomes in the era of novel agents, it remains largely in...
Novel Drug for Cancer Immunotherapy that Targets Phosphatidylserine
Abstract Phosphatidylserine (PS) is emerging as an attractive immunotherapeutic target in the light of mounting evidence highlighting its causal link to immune suppression.We have...
Implementing Photodissociation Mass Spectrometry to study Disease and Lipid Structure
Abstract Lipids fulfill an array of cellular functions by composing cellular membranes, engaging in signaling pathways, and modulating protein structure.Disruptions in carefully re...
Implementing Photodissociation Mass Spectrometry to study Disease and Lipid Structure
Abstract Lipids fulfill an array of cellular functions by composing cellular membranes, engaging in signaling pathways, and modulating protein structure. Disruptions in carefully r...
Investigating the Role of Cdc73 in T-cell Acute Lymphoblastic Leukemia (T-ALL)
PROJECT SUMMARY About 60% of T-cell acute lymphoblastic leukemia (T-ALL) patients have activating NOTCH1 mutations, making NOTCH1 the most prevalent oncogene in this cancer. In ear...