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Showing 18,90118,920 of 20,252 grants

Completed TRAINING, INDIVIDUAL
Role of NOTCH1 Signaling in Engineering CD4+ T Cells for Cancer Immunotherapy
NATIONAL CANCER INSTITUTE University of Washington United States 2021 – 2024

PROJECT SUMMARY Current methods for engineering T cells for cancer immunotherapy use agonistic anti-CD3 and -CD28 monoclonal antibodies (mAb) to activate T cells, which induce thei...

$517.5K
USD
Completed TRAINING, INDIVIDUAL
The Dependency on MYOD for Growth in Rhabdomyosarcoma
NATIONAL CANCER INSTITUTE State University New York Stony Brook United States 2021 – 2025

Project Summary Rhabdomyosarcoma (RMS) is the most common extra-cranial solid tumor in the pediatric population of the United States by incidence. RMS is a high-grade neoplasm comp...

$551.9K
USD
Completed TRAINING, INDIVIDUAL
Role of NOTCH1 Signaling in Engineering CD4+ T Cells for Cancer Immunotherapy
NATIONAL CANCER INSTITUTE University of Washington United States 2021 – 2024

PROJECT SUMMARY Current methods for engineering T cells for cancer immunotherapy use agonistic anti-CD3 and -CD28 monoclonal antibodies (mAb) to activate T cells, which induce thei...

$526.9K
USD
Completed TRAINING, INDIVIDUAL
The Dependency on MYOD for Growth in Rhabdomyosarcoma
NATIONAL CANCER INSTITUTE State University New York Stony Brook United States 2021 – 2025

Project Summary Rhabdomyosarcoma (RMS) is the most common extra-cranial solid tumor in the pediatric population of the United States by incidence. RMS is a high-grade neoplasm comp...

$569.7K
USD
Completed NON-SBIR/STTR RPGS
Quantitative histopathology for cancer prognosis using quantitative phase imaging on stained tissues
NATIONAL CANCER INSTITUTE University of Illinois At Urbana-Champai... United States 2021 – 2024

Summary Fast, accurate, and scalable testing has been recognized unanimously as crucial for mitigating the impact of COVID-19 and future pandemics. We propose a technology that all...

$5.76M
USD
Completed TRAINING, INDIVIDUAL
The Dependency on MYOD for Growth in Rhabdomyosarcoma
NATIONAL CANCER INSTITUTE State University New York Stony Brook United States 2021 – 2025

Project Summary Rhabdomyosarcoma (RMS) is the most common extra-cranial solid tumor in the pediatric population of the United States by incidence. RMS is a high-grade neoplasm comp...

$408.9K
USD
Completed NON-SBIR/STTR RPGS
Development of B-cell-based vaccine for Glioblastoma
NATIONAL CANCER INSTITUTE Northwestern University At Chicago United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Immunotherapy has revolutionized the treatment of many tumors. However, most GBM patients have not, so far, benefited from immunotherapeutic treatment.With...

$3.64M
USD
Completed NON-SBIR/STTR RPGS
Satisfaction of Search in Breast Cancer Detection
NATIONAL CANCER INSTITUTE University of Iowa United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Breast cancer has the highest incidence of cancer for women in the U.S. and across the world.Despite advances in technology?from film-screen images to Full...

$6.73M
USD
Completed NON-SBIR/STTR RPGS
Treatment of parathyroid neoplasia by pharmacologic cdk4/6 inhibition
NATIONAL CANCER INSTITUTE University of Connecticut Sch of Med/Dnt United States 2021 – 2023

Project Summary: Parathyroid cancer is a rare, but typically incurable malignancy. Prolonged elevation of parathyroid hormone and accompanying hypercalcemia cause significant morbi...

$820K
USD
Completed NON-SBIR/STTR RPGS
Optimizing Tobacco Treatment Delivery for People Living with HIV
NATIONAL CANCER INSTITUTE Medical University of South Carolina United States 2021 – 2026

With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, and are less likely to die from...

$4.35M
USD
Completed NON-SBIR/STTR RPGS
Development of B-cell-based vaccine for Glioblastoma
NATIONAL CANCER INSTITUTE Northwestern University At Chicago United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Immunotherapy has revolutionized the treatment of many tumors. However, most GBM patients have not, so far, benefited from immunotherapeutic treatment. Wit...

$3.59M
USD
Completed NON-SBIR/STTR RPGS
Satisfaction of Search in Breast Cancer Detection
NATIONAL CANCER INSTITUTE University of Iowa United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Breast cancer has the highest incidence of cancer for women in the U.S. and across the world. Despite advances in technology—from film-screen images to Ful...

$6.04M
USD
Completed NON-SBIR/STTR RPGS
Satisfaction of Search in Breast Cancer Detection
NATIONAL CANCER INSTITUTE University of Iowa United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Breast cancer has the highest incidence of cancer for women in the U.S. and across the world. Despite advances in technology—from film-screen images to Ful...

$5.83M
USD
Completed NON-SBIR/STTR RPGS
Treatment of parathyroid neoplasia by pharmacologic cdk4/6 inhibition
NATIONAL CANCER INSTITUTE University of Connecticut Sch of Med/Dnt United States 2021 – 2024

Project Summary: Parathyroid cancer is a rare, but typically incurable malignancy. Prolonged elevation of parathyroid hormone and accompanying hypercalcemia cause significant morbi...

$820K
USD
Completed NON-SBIR/STTR RPGS
Optimizing Tobacco Treatment Delivery for People Living with HIV
NATIONAL CANCER INSTITUTE Medical University of South Carolina United States 2021 – 2026

With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, and are less likely to die from...

$4.83M
USD
Completed NON-SBIR/STTR RPGS
Optimizing Tobacco Treatment Delivery for People Living with HIV Diversity Supplement
NATIONAL CANCER INSTITUTE Medical University of South Carolina United States 2021 – 2026

Summary of the Parent Grant: With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, an...

$338.8K
USD
Completed NON-SBIR/STTR RPGS
Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy
NATIONAL CANCER INSTITUTE University of California Los Angeles United States 2021 – 2026

Abstract Radiotherapy is used to treat 60% of the cancer patients and 40% of curative cases.However, normal tissue toxicities still prevent radiotherapy from achieving more effecti...

$5.95M
USD
Completed NON-SBIR/STTR RPGS
Satisfaction of Search in Breast Cancer Detection
NATIONAL CANCER INSTITUTE University of Iowa United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Breast cancer has the highest incidence of cancer for women in the U.S. and across the world. Despite advances in technology—from film-screen images to Ful...

$6.02M
USD
Completed NON-SBIR/STTR RPGS
Optimizing Tobacco Treatment Delivery for People Living with HIV
NATIONAL CANCER INSTITUTE Medical University of South Carolina United States 2021 – 2026

With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, and are less likely to die from...

$4.83M
USD
Completed NON-SBIR/STTR RPGS
Optimizing Tobacco Treatment Delivery for People Living with HIV
NATIONAL CANCER INSTITUTE Medical University of South Carolina United States 2021 – 2026

With advances in antiretroviral therapy (ART), people living with HIV (PLWH) are living longer, are more likely to die from non-AIDS-related causes, and are less likely to die from...

$709.2K
USD