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20,252 grants found
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Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations
PROJECT SUMMARY / ABSTRACT Cancer is the leading disease-related cause of death in children.Treatment has remained largely unchanged in decades, relying primarily on aggressive cyt...
Immunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune Compartments
PROJECT SUMMARY The immune system remarkably distinguishes between self and non-self/self-aberrant antigens, affording exquisite anti-tumor specificity and inhibition of tumorigene...
A novel PARP inhibitor PET tracer for breast cancer
Project Description: A novel PARP inhibitor PET tracer for breast cancer Breast cancer is the most common cancer in women, and 1 in 8 women will develop invasive breast cancer in h...
Molecular mechanisms driving mesenchymal colorectal cancer
SUMMARY A stem-mesenchymal phenotype of the tumor epithelium, and its associated immunosuppressive and desmoplastic stroma, are fundamental characteristics of the most aggressive a...
Molecular mechanisms driving mesenchymal colorectal cancer
SUMMARY A stem-mesenchymal phenotype of the tumor epithelium, and its associated immunosuppressive and desmoplastic stroma, are fundamental characteristics of the most aggressive a...
Molecular mechanisms driving mesenchymal colorectal cancer
SUMMARY A stem-mesenchymal phenotype of the tumor epithelium, and its associated immunosuppressive and desmoplastic stroma, are fundamental characteristics of the most aggressive a...
Immunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune Compartments
PROJECT SUMMARY The immune system remarkably distinguishes between self and non-self/self-aberrant antigens, affording exquisite anti-tumor specificity and inhibition of tumorigene...
Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations
PROJECT SUMMARY / ABSTRACT Cancer is the leading disease-related cause of death in children. Treatment has remained largely unchanged in decades, relying primarily on aggressive cy...
A novel PARP inhibitor PET tracer for breast cancer
Project Description: A novel PARP inhibitor PET tracer for breast cancer Breast cancer is the most common cancer in women, and 1 in 8 women will develop invasive breast cancer in h...
Molecular mechanisms driving mesenchymal colorectal cancer
SUMMARY A stem-mesenchymal phenotype of the tumor epithelium, and its associated immunosuppressive and desmoplastic stroma, are fundamental characteristics of the most aggressive a...
Stopping PDA progression using inhibitors of CSC dissemination and immunotherapy
PROJECT SUMMARY Pancreatic Ductal Adenocarcinoma (PDA) is often called the silent serial killer, because it rarely causes symptoms and metastases have already spread from the pancr...
Immunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune Compartments
PROJECT SUMMARY The immune system remarkably distinguishes between self and non-self/self-aberrant antigens, affording exquisite anti-tumor specificity and inhibition of tumorigene...
Immunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune Compartments
PROJECT SUMMARY The immune system remarkably distinguishes between self and non-self/self-aberrant antigens, affording exquisite anti-tumor specificity and inhibition of tumorigene...
A novel PARP inhibitor PET tracer for breast cancer
Project Description: A novel PARP inhibitor PET tracer for breast cancer Breast cancer is the most common cancer in women, and 1 in 8 women will develop invasive breast cancer in h...
Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations
PROJECT SUMMARY / ABSTRACT Cancer is the leading disease-related cause of death in children. Treatment has remained largely unchanged in decades, relying primarily on aggressive cy...
Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations
PROJECT SUMMARY / ABSTRACT Cancer is the leading disease-related cause of death in children. Treatment has remained largely unchanged in decades, relying primarily on aggressive cy...
A new mouse model for testing splice-switching therapies in IGF-driven cancers
ABSTRACT Hepatocellular Carcinoma (HCC) is predicted to be the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide. Rates of both incidence...
Role of NOTCH1 Signaling in Engineering CD4+ T Cells for Cancer Immunotherapy
PROJECT SUMMARY Current methods for engineering T cells for cancer immunotherapy use agonistic anti-CD3 and -CD28 monoclonal antibodies (mAb) to activate T cells, which induce thei...
The Dependency on MYOD for Growth in Rhabdomyosarcoma
Project Summary Rhabdomyosarcoma (RMS) is the most common extra-cranial solid tumor in the pediatric population of the United States by incidence.RMS is a high-grade neoplasm compo...
A new mouse model for testing splice-switching therapies in IGF-driven cancers
ABSTRACT Hepatocellular Carcinoma (HCC) is predicted to be the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide.Rates of both incidence a...