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20,252 grants found
Showing 18,861 – 18,880 of 20,252 grants
Studies on ORC and double strand DNA break repair
REVISED ABSTRACTReplication initiation in eukaryotes is believed to be dependent on a six subunit, ATP-dependent complex of proteins, the Origin Recognition Complex (ORC), which lo...
Targeting MBNL1-mediated alternative splicing in MLL-fusion leukemia
Proposal Summary/Abstract: Though outcomes for pediatric acute leukemia have improved dramatically over the last few decades, infant leukemia is a particularly aggressive disease w...
Studies on ORC and double strand DNA break repair
REVISED ABSTRACTReplication initiation in eukaryotes is believed to be dependent on a six subunit, ATP-dependent complex of proteins, the Origin Recognition Complex (ORC), which lo...
Targeting MBNL1-mediated alternative splicing in MLL-fusion leukemia
Proposal Summary/Abstract: Though outcomes for pediatric acute leukemia have improved dramatically over the last few decades, infant leukemia is a particularly aggressive disease w...
Studies on ORC and double strand DNA break repair
REVISED ABSTRACTReplication initiation in eukaryotes is believed to be dependent on a six subunit, ATP-dependent complex of proteins, the Origin Recognition Complex (ORC), which lo...
Targeting MBNL1-mediated alternative splicing in MLL-fusion leukemia
Proposal Summary/Abstract: Though outcomes for pediatric acute leukemia have improved dramatically over the last few decades, infant leukemia is a particularly aggressive disease w...
Predictors of Systemic Exposure to Oral 6MP During Maintenance in Adolescentsand Young Adults with Acute Lymphoblastic Leukemia
PROJECT SUMMARY / ABSTRACT Patients diagnosed with cancer between the ages of 15-39y have not seen the same improvement in survival when compared with patients diagnosed as childre...
Breast Cancer PARP PET Imaging AIP to Support FDA Approval & Commercialization
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitor drugs (PARPi's) have emerged as important new therapeutic agents targeting a broadening class of gene mutations present...
Predictors of Systemic Exposure to Oral 6MP During Maintenance in Adolescentsand Young Adults with Acute Lymphoblastic Leukemia
PROJECT SUMMARY / ABSTRACT Patients diagnosed with cancer between the ages of 15-39y have not seen the same improvement in survival when compared with patients diagnosed as childre...
Breast Cancer PARP PET Imaging AIP to Support FDA Approval & Commercialization
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitor drugs (PARPi's) have emerged as important new therapeutic agents targeting a broadening class of gene mutations present...
Predictors of Systemic Exposure to Oral 6MP During Maintenance in Adolescentsand Young Adults with Acute Lymphoblastic Leukemia
PROJECT SUMMARY / ABSTRACT Patients diagnosed with cancer between the ages of 15-39y have not seen the same improvement in survival when compared with patients diagnosed as childre...
Breast Cancer PARP PET Imaging AIP to Support FDA Approval & Commercialization
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitor drugs (PARPi's) have emerged as important new therapeutic agents targeting a broadening class of gene mutations present...
Predictors of Systemic Exposure to Oral 6MP During Maintenance in Adolescentsand Young Adults with Acute Lymphoblastic Leukemia
PROJECT SUMMARY / ABSTRACT Patients diagnosed with cancer between the ages of 15-39y have not seen the same improvement in survival when compared with patients diagnosed as childre...
Breast Cancer PARP PET Imaging AIP to Support FDA Approval & Commercialization
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitor drugs (PARPi's) have emerged as important new therapeutic agents targeting a broadening class of gene mutations present...
Epigenetic Mechanisms of Drug Resistance in Renal Cell Carcinoma
Receptor tyrosine kinase inhibitors (RTKIs) such as sunitinib, pazopanib and axitinib are effective treatments for clear cell renal cell carcinoma (ccRCC) patients. However, resist...
Epigenetic Mechanisms of Drug Resistance in Renal Cell Carcinoma
Receptor tyrosine kinase inhibitors (RTKIs) such as sunitinib, pazopanib and axitinib are effective treatments for clear cell renal cell carcinoma (ccRCC) patients. However, resist...
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease Outcomes
ABSTRACT Cirrhosis – the end-stage result of chronic liver disease – is a condition with high morbidity and mortality that is becoming increasingly common. Nearly half of all patie...
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease Outcomes
ABSTRACT Cirrhosis ? the end-stage result of chronic liver disease ? is a condition with high morbidity and mortality that is becoming increasingly common.Nearly half of all patien...
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease Outcomes
ABSTRACT Cirrhosis – the end-stage result of chronic liver disease – is a condition with high morbidity and mortality that is becoming increasingly common. Nearly half of all patie...
Multi-level Evaluation of Racial/ethnic Disparities in Liver Disease Outcomes
ABSTRACT Cirrhosis – the end-stage result of chronic liver disease – is a condition with high morbidity and mortality that is becoming increasingly common. Nearly half of all patie...