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20,252 grants found
Showing 18,841 – 18,860 of 20,252 grants
BET degraders for improving colorectal cancer therapy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the US.Developing novel and more effective CRC therapies is an unmet biomed...
Profilin biology in breast cancer
Breast cancer the most frequently diagnosed non-skin cancer in women, ranks second among cancer deaths in women in the United States. The vast majority of these deaths are due to m...
HER2-mediated delivery of cytotoxic agents in solid tumors
PROJECT SUMMARY ERBB2/HER2 is a receptor tyrosine kinase (RTK) that is amplified/overexpressed in 15-20% of breast and gastroesophageal cancers, for which anti-HER2 therapy is now...
Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer
Project Summary Despite the advent of aggressive cervical cancer screening programs, cervical cancer remains one of the most common cancers affecting women under age 35, and the fo...
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
ABSTRACT Clonal hematopoesis (CH) defined as the presence of acquired mutations detectable in peripheral blood of normal healthy individuals without hematologic malignancies (HM) h...
The selective advantage of mismatch repair loss in colonic stem cells
Project Summary Lynch syndrome (LS) is a hereditary disease that predisposes patients to colorectal, endometrial, ovarian and other cancers.LS is caused by inherited mutations in t...
Molecular Pathogenesis and Therapy of Systemic Histiocytic Neoplasms
Project Summary Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage that include Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Juven...
Optimizing Dual-Targeted and Dual-Armored CAR T Cells for Small Cell Lung Cancer
ABSTRACT A patient's own T cells can be modified using gene therapy technology to express receptors, termed chimeric antigen receptors or CARs, which allow these immune T cell...
Stem Cell-based Platform for Targeted Enzyme/Prodrug Therapy of Recurrent Ovarian Cancer
Project Summary: Ovarian cancer (OC) is associated with the highest mortality rate of all gynecologic malignancies in the United States.The low rate of survival is mainly due to tw...
Development of an NTSR1-Targeted Radiotherapeutic for Colorectal Cancer
Objective: More effective treatment options are needed across all clinical stages of colorectal cancer (CRC), from eliminating residual disease after surgery, improving surgical ca...
Methods for improved detection of activated molecular pathways in cancer
PROJECT SUMMARY/ABSTRACT Studying tumors by quantifying gene expression via RNA-sequencing (RNA-seq) has proven crucial to elucidating their active biological pathways and processe...
Design and Application of Cationic Nanocarriers to Inhibit Breast Cancer Progression in Primary and Metastatic Sites
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen/progesterone receptors and human epidermal growth factor receptor 2 (HER2) expression...
Dissecting new mechanisms of lysosome quality control in health and disease
PROJECT SUMMARY Lysosomes function as critical nodes for macromolecular recycling, metabolic rewiring, and pro-growth signaling in cells.Accordingly, defects in lysosome function u...
2021 Annual Conference Grant: American Society of Preventive Oncology
ABSTRACT The mission of the American Society of Preventive Oncology (ASPO) is the exchange and translation of scientific information to reduce the cancer burden and for the continu...
Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities
ABSTRACT Soft-tissue sarcomas are heterogeneous tumors that originate from cells belonging to the mesenchymal lineages, and that affect almost 200,000 individuals worldwide each ye...
Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities
ABSTRACT Soft-tissue sarcomas are heterogeneous tumors that originate from cells belonging to the mesenchymal lineages, and that affect almost 200,000 individuals worldwide each ye...
Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities
ABSTRACT Soft-tissue sarcomas are heterogeneous tumors that originate from cells belonging to the mesenchymal lineages, and that affect almost 200,000 individuals worldwide each ye...
Comparative modeling of sarcoma microenvironments for the discovery of biomarkers and tumor vulnerabilities
ABSTRACT Soft-tissue sarcomas are heterogeneous tumors that originate from cells belonging to the mesenchymal lineages, and that affect almost 200,000 individuals worldwide each ye...
Targeting MBNL1-mediated alternative splicing in MLL-fusion leukemia
Proposal Summary/Abstract: Though outcomes for pediatric acute leukemia have improved dramatically over the last few decades, infant leukemia is a particularly aggressive disease w...
Studies on ORC and double strand DNA break repair
REVISED ABSTRACT Replication initiation in eukaryotes is believed to be dependent on a six subunit, ATP-dependent complex of proteins, the Origin Recognition Complex (ORC), which l...