Browse All Grants
20,252 grants found
Showing 18,821 – 18,840 of 20,252 grants
Innovative Droplet Lenses for NextGen Light Sensors of Biomarkers of Inflammation
Project Summary/Abstract While the efficacy of immunotherapy can be staggering, a major side effect is that there can be an ensuing excessively robust immune response, which can le...
Genetic Predisposition to Chronic Lymphocytic Leukemia (CLL)
Project Summary CLL is the most common leukemia of adults in North America, with about 20,000 new cases per year, and remains incurable.Although a small subset of patients has indo...
Mitochondrial heterogeneity as the origin of chemoresistance in pancreatic cancer
Summary Therapeutic resistance and tumor relapse present as major barriers to achieving a definitive cure for cancer.This challenge is especially relevant for patients with pancrea...
Targeting posttranslational modifications of B7-H4 in carcinogenesis and therapy
Targeting post-translational modifications of B7-H4 in carcinogenesis and therapy The goal of this project is to determine the impact of interplay between glycosylation and ubiquit...
Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis
N-methyltransferase (NNMT), a key enzyme in the NAD+ salvage pathway with unclear functions, is expressed highly and specifically in basal-like breast cancer (BLBC). We found that...
Novel TYRO3 inhibitors for treatment of cancer
TYRO3 is a member of the TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases.All three family members are aberrantly expressed in cancer cells, where they function to promo...
SMARCB1 regulated SWI/SNF complex function in Malignant Rhabdoid Tumors
PROJECT SUMMARY A research program will be undertaken to study SMARCB1-regulated SWI/SNF complex function in malignant rhabdoid tumors.Over the past few years, major cancer genome...
Modeling cancer risk and environmental and socio-spatial exposures using residential histories
In many studies on the risk of disease, investigators analyze the spatial patterns of health outcomes and evaluate residential environmental exposures at the time of study enrollme...
Optimizing Therapeutic STING Agonism in Triple Negative Breast Cancer
PROJECT SUMMARY Despite the therapeutic promise of STING agonists in cancer, first in human studies have been hampered by lack of precision therapy and issues with drug delivery.My...
Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome
ABSTRACT While the outcomes for children with acute lymphoblastic leukemia (ALL) have improved dramatically over the past four decades, major challenges remain including the burden...
Changing Contraceptive Patterns and Ovarian Cancer Risk
ABSTRACT Contraceptive patterns are changing and the implications for ovarian cancer risk are unknown.Oral contraceptives (OCs), which are an established protective factor for ovar...
Targeting posttranslational modifications of CD73 in TNBCs
Targeting posttranslational modification of CD73 in TNBC The goal of this project is to determine the impact of proteolytic regulation of CD73 by the E3 ligase TRIM21 in breast car...
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin state
PROJECT SUMMARY Recent whole-exome sequencing studies in human cancer and neurodevelopmental disorders have unmasked frequent mutations in genes encoding chromatin regulatory prote...
Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.
PROJECT SUMMARY/ABSTRACT Immunotherapy induces durable remissions in a subset of patients with highly mutated cancers. However, most cancers are modestly mutated and fail to respon...
Mechanisms of adhesion and invasion in hyaluronic acid matrices
PROJECT SUMMARY/ABSTRACT Hyaluronic acid (HA) is the most abundant component of the human brain, where it serves essential structural, mechanical, and cell-instructive functions.Ad...
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy
PROJECT SUMMARY: Pancreatic ductal adenocarcinoma (PDA) will become the 2nd leading cause of cancer deaths in the United States by 2030.Most patients with PDA present with nonresec...
Mechanisms of cysteinyl leukotriene receptor 2 (CysLT2R)-mediated signaling and migration in melanocytes and uveal melanoma
PROJECT SUMMARY (ABSTRACT) Melanocytes comprise a heterogeneous group of neural crest-derived cells that are present in the skin, eyes, ear, heart, and brain.While the function of...
The Identity of the Notch Ankyrin Repeat Domain as a Determinant of Isoform-Specific Notch Signaling
Project Summary/Abstract: The Notch signaling pathway is a crucial regulator of development and cell differentiation in almost all animal organs and tissues.The Notch receptor is a...
PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
Project Summary: Illness behaviors, metabolic disturbances, and cognitive decline are common in patients with chronic systemic diseases, and contribute substantially to quality of...
Targeting Lipid Metabolism in Colorectal Cancer
PROJECT SUMMARY Metastasis is the main cause of death from solid tumors including colorectal cancer (CRC).Our long-term goal is to develop more selective therapeutic options to pre...