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20,252 grants found
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Longitudinal Proteomic and Metabolomic Predictors of Pancreatic Cyst Malignant Progression and Early Stage Pancreatic Cancer
Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDAC) has a dire prognosis mainly due to its late diagnosis. It is vital to identify early-stage PDAC and its precursors....
Epigenetic Control and Genome Organization
OVERALL PROGRAM SUMMARY Gary Stein and Janet Stein, Program Directors Our Program Project is a thematically, experimentally and operationally integrated multidisciplinary team appr...
Project 1: Mitotic Gene Bookmarking as an Epigenetic Mechanism to Maintain the Mammary Epithelial Phenotype
PROJECT 1 | SUMMARY Mechanisms underlying the epithelial to mesenchymal transition (EMT)?a normal developmental process and an early event at the onset of epithelium-derived cancer...
Project 2: Bromodomains as Epigenetic Modulators of Endocrine Responsiveness in ER+ Breast Cancer
PROJECT 2: SUMMARY Breast cancer (BCa) ranks among the leading causes of cancer death in women worldwide.Estrogen Receptor alpha positive tumors (ER+) are the most common subtype o...
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
SUMMARY Long non-coding RNAs (lncRNAs) are epigenetic regulators of the chromatin organization supporting cancer cell activities.There is a gap in the literature identifying the ch...
Administration and Coordination Core
SUMMARY/ABSTRACT Administration and Coordination Core Gary Stein, Core Leader; Janet Stein, Co-Leader The Administration and Coordination Core will provide leadership, and administ...
Experimental Integration, Design and Analysis Core
Summary: Experimental Integration, Design and Analysis Core The Experimental Integration, Design, and Analysis (EIDA) Core is an essential component of the program project that is...
Joint receptor and protein expression immunophenotyping through split-pool barcoding
Single-cell immune repertoire sequencing can provide invaluable information about the response of the adaptive immune system to disease and therapy.However, existing approaches for...
Accurate DCE-MRI Measurement of Glioblastoma using Point-of-care Portable Perfusion Phantom
PROJECT SUMMARY / ABSTRACT The goal of this R03 study is to conduct a pilot study testing whether the variability in quantitative DCE- MRI measurement of glioblastoma across differ...
Two photon fluorescence microscopy for dermatologic surgery and biopsy
Medicare reimburses over 5 million biopsies resulting in 1.5 million surgical procedures annually for nonmelanoma skin cancer (NMSC).Despite its burden on the health care system, t...
Eco-evolutionary drivers of clonal dynamics during UV-induced skin carcinogenesis (PQ3)
ABSTRACT Cancers have readily-defined characteristics often referred to as ?hallmarks?.Nevertheless, the question of how the sequence of cancer development progresses -- from norma...
Inflammatory oxylipins and aromatase inhibitor toxicity in breast cancer
PROJECT SUMMARY Treatment with an aromatase inhibitor (AI), which significantly decreases circulating estrogen concentrations, for 5-10-years reduces 10-year breast cancer mortalit...
Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma
Sarcomatoid renal cell carcinoma (sRCC) represents an aggressive group of renal epithelial tumors characterized by histopathological features of epithelial?mesenchymal plasticity (...
Imaging and manipulating oncoprotein phase separation and compartmentalization
Abstract MYC oncoproteins including c-Myc and MYCN are major drivers of human tumorigenesis. Expression of MYC is deregulated and enhanced in many types of human cancer. For instan...
Investigating the roles of extracellular cGAMP and harnessing it for cancer treatment
PROJECT SUMMARY The goal of cancer immunotherapy is to awaken the body?s anti-tumoral immune response to fight against all cancers in all patients. Our lab recently identified a ke...
Mathematical Model-Guided Adoptive Immunotherapy in Bladder Cancer
Summary Bladder cancer is the fourth most common cancer in men and a leading cause of cancer mortality among men and women with the rates of bladder cancer incidents and bladder ca...
Targeting replication stress signaling to overcome immune evasion in small cell lung cancer
New therapeutic strategies are urgently needed to improve immune checkpoint blockade (ICB) therapy in small cell lung cancer (SCLC). SCLCs rely heavily on the replication stress re...
Geranylgeranyl diphosphate synthase inhibitor therapy for multiple myeloma
Project Summary Multiple myeloma (MM) is an incurable bone marrow (BM) cancer characterized by the production of monoclonal protein (MP). Development of drug resistance and off-tar...
Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer
Project Summary Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer Women with germline mutations in BRCA1 and BRCA2 (BRCA carriers) are at high ris...
Eliminating B Cell Precursor Acute Lymphoblastic Leukemia by Targeting the Uniquely Specific Pre-B Cell Receptor
ABSTRACT B cell precursor acute lymphoblastic leukemia (BCP-ALL), a malignancy that arises from mutant pre-B cells, is the most common childhood leukemia but also occurs in adults....