Browse All Grants
20,252 grants found
Showing 18,781 – 18,800 of 20,252 grants
Automated Assessment for Robotic Suturing Utilizing Deep Learning Algorithms
ABSTRACT Medical errors are the third leading cause of death in the US at a cost of $20 billion annually. Surgical complications account for a third of these deaths and cost. Surgi...
Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer
Project Summary Despite the advent of aggressive cervical cancer screening programs, cervical cancer remains one of the most common cancers affecting women under age 35, and the fo...
Estrogen receptor fusions genes as drivers of endocrine resistance in breast cancer
Anti-estrogen therapy is key to the prevention and treatment of estrogen receptor (ER, ESR1) positive breast cancer, but therapy resistance occurs in up to a half of cases resultin...
Mutational cooperativity in TET2-associated hematological malignancies.
Project Summary/ Abstract Peripheral T cell lymphoma (PTCL) represents a group of aggressive blood cancers derived from mature T cells, and remains as a high unmet clinical need wi...
Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial
PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is n...
Imaging and manipulating oncoprotein phase separation and compartmentalization
Abstract MYC oncoproteins including c-Myc and MYCN are major drivers of human tumorigenesis. Expression of MYC is deregulated and enhanced in many types of human cancer. For instan...
Minibeam Radiation Therapy Enhanced Delivery of Nanoparticle Anticancer Agents to Pancreatic Cancer Tumors
PROJECT SUMMARY / ABSTRACT: Nanoparticles (NPs) hold great promise for delivering more effective and safer cancer treatment than the small molecule drugs that are commonly used. Th...
PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
Project Summary: Illness behaviors, metabolic disturbances, and cognitive decline are common in patients with chronic systemic diseases, and contribute substantially to quality of...
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
PROJECT SUMMARY Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanisms, res...
Improving efficacy of radioiodine treatment of thyroid cancer
Patients with advanced thyroid cancer are frequently refractory to radioiodine (RAI) therapy. Oncoproteins that constitutively activate MAPK signaling suppress expression of genes...
Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias
PROJECT SUMMARY The mixed-lineage leukemia (MLL) gene rearrangements account for approximately 80% of infant acute lymphoblastic leukemia (ALL) and 35-50% of infant acute myeloid l...
Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1
PROJECT SUMMARY While the technological enterprise of magnetic resonance imaging (MRI) generates a host of biomarkers of the tumor environment, in particular for breast cancer, pre...
Effectiveness and implementation of a health system intervention to improve quality of cancer care for rural, underserved patients
PROJECT SUMMARY There is growing evidence that limited access to high-quality cancer treatment is one of the main drivers of higher cancer mortality rates among rural cancer patien...
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences
Project Abstract Live cell reporters of genetic changes in stiff vs soft surroundings ? causes & consequences Solid tumors are often palpably stiff and more constrained in 3D g...
Exploring novel SRC-regulated pathways in IDH mutant intrahepatic cholangiocarcinoma
PROJECT SUMMARY/ABSTRACT Intrahepatic cholangiocarcinoma (ICC) is a highly lethal form of liver cancer which has been rising in incidence worldwide and carries a prognosis of under...
Molecular mechanism of EGFRs protein-protein interaction inhibition by a grafted peptide in NSCLC
Project Summary: The long-term objective of this research project is to understand the role of dimerization in extracellular domains (ECD) of epidermal growth factor receptors (EGF...
Efficacy of a Mindfulness-Based Stress Management Program for Allogeneic HCT Caregivers
PROJECT SUMMARY/ABSTRACT Caring for an allogeneic hematopoietic stem cell transplant (HCT) patient is a significant responsibility, involving a commitment to be available 24/7 up t...
A Multi-pronged Computational Approach to Advance Kinase Drug Discovery
Project Summary/Abstract In recent years, computing speed has exponentially increased; however, the potential of computational ap- proaches to accelerate drug discovery has not bee...
The Adenosinergic Pathway in Tumor-derived Exosomes
PROJECT SUMMARY/ABSTRACT Tumor cells produce and release large numbers of extracellular vesicles (EVs).A subset of small (30-150 nm) EVs derived from the endocytic compartment of t...