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20,252 grants found
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Modifiable Determinants of Disparities in Multiple Myeloma Treatment Patterns
PROJECT SUMMARY/ABSTRACT In this K99/R00 Pathway to Independence Award for Outstanding Early-Stage Postdoctoral Researchers application, Dr. Hamlet Gasoyan outlines a detailed prop...
Targeted disruption of the YAP/TAZ/TEAD axis in pancreatic cancer
Project Summary (as stated in parent grant) Pancreatic ductal adenocarcinoma (PDAC) is a devastating form of pancreatic cancer with dismal patient outcome. KRAS, which is commonly...
Functional modeling of race-specific features underlying phenotypic reprogramming in metastatic stem cells from colorectal cancer patients
PROJECT SUMMARY (unchanged from Parent R37) Metastasis causes >90% of cancer death. The persistence and lethality of metastasis is driven by cells capable of self-renewal, slow...
Quantitative analysis and manipulation of chromosome dynamics in cancer organoids
Project Summary/Abstract Most tumors are not homogeneous, but rather comprised of highly distinct and heterogenous cancer cell populations. Adjacent cells within a tumor may harbor...
Innovative approaches to randomized behavioral clinical trials
PROJECT SUMMARY This advanced-level short course will provide intensive training in innovative approaches for designing and conducting randomized clinical trials (RCTs) of behavior...
A New Paradigm to Prevent and Treat Micrometastases
Abstract Metastsis is the direct cause of the majority of deaths in patients with solid tumors, thus representing a major unmet medical need. In some cancer types, microscopic meta...
TO Title: Contract Orientation & Kickoff Meeting for Preclinical Services for PREVENT Base IDIQ Title: PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate E
PREVENT EFFICACY Pool: This contract supports the PREVENT Cancer Preclinical Drug Development Program, which provides a structured approach to drug and vaccine development, from di...
Contract Orientation and Kickoff Meeting
This contract supports the PREVENT Cancer Preclinical Drug Development Program, which provides a structured approach to drug and vaccine development, from discovery to the clinic....
TO Title: Contract Orientation & Kickoff Meeting for Preclinical Services for PREVENTBase IDIQ Title: PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate End
PREVENT EFFICACY Pool: This contract supports the PREVENT Cancer Preclinical Drug Development Program, which provides a structured approach to drug and vaccine development, from di...
Contract Orientation and Kickoff Meeting
PREVENT EFFICACY Pool: This contract supports the PREVENT Cancer Preclinical Drug Development Program, which provides a structured approach to drug and vaccine development, from di...
Contract Orientation and Kickoff Meeting
This contract supports the PREVENT Cancer Preclinical Drug Development Program, which provides a structuredapproach to drug and vaccine development, from discovery to the clinic. T...
Contract Orientation and Kickoff Meeting
The objective of the “Preclinical PREVENT Cancer Program: Toxicology and Pharmacology Testing” IDIQ contracts will be to continue evaluation of the pharmacological and toxicologica...
Tumor Metabolism
ABSTRACT Support is requested for a Keystone Symposia conference entitled Tumor Metabolism, organized by Drs. Gina DeNicola, Rushika Perera and David Shackelford. The conference wi...
A multimodal single-cell approach to developing personalized combinatorial treatments for glioblastoma
A major impediment to the treatment of glioblastoma (GBM) is its extensive intratumoral heterogeneity: Each GBM tumor is heterogeneous with respect to genetics, immune microenviron...
Glut1+ cancer associated fibroblasts enforce a metabolic barrier to tumor T cell infiltration
PROJECT SUMMARY T cell trafficking to tumors represents a critical process in the tumor immunity cycle. However, many tumors can recruit T cells to the tumor, but these T cells are...
Dietary Control of the Pro-Metastatic Niche in Colorectal Cancer
PROJECT SUMMARY Colorectal cancer (CRC) metastasis is a major cause of mortality, yet there is a distinct lack of therapies targeting metastasis. Among the major modifiable externa...
Integrating patient-reported outcomes and T-cell receptor sequencing to predict immune-related adverse events
Abstract. This proposal is disease agnostic and patient centered, focusing on symptoms associated with side effects of immune checkpoint inhibitors (ICPis). Although ICPis are effe...
Developing TCR-T cell therapy in renal cell carcinoma
Abstract T cells play a central role in the anti-cancer immune response. Engineering and administrating tumor-specific T cells have successfully treated some types of cancer. Compa...
Mechanisms of metabolic reprogramming by PIK3CA oncogenic mutations
The goal of this competitive renewal is to interrogate a paradigm-shifting hypothesis that a combination of CB- 839, a glutaminase inhibitor, and 5-FU induces neutrophil extracellu...
Breaching the Tumor-Immune Mechanical Barrier for Optimal Antitumor Immunity
Project Summary/Abstract Tumor immune exclusion predicts poor anticancer therapeutic responses and patient outcomes. The mechanical barrier built by intercellular junction connecti...