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20,252 grants found
Showing 18,761 – 18,780 of 20,252 grants
Eco-evolutionary drivers of clonal dynamics during UV-induced skin carcinogenesis (PQ3)
ABSTRACT Cancers have readily-defined characteristics often referred to as “hallmarks”. Nevertheless, the question of how the sequence of cancer development progresses -- from norm...
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin state
PROJECT SUMMARY Recent whole-exome sequencing studies in human cancer and neurodevelopmental disorders have unmasked frequent mutations in genes encoding chromatin regulatory prote...
FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma
PROJECT SUMMARY Ewing Sarcoma Family of Tumors (ESFT) are bone and soft tissue cancers that affect children and adolescents. Surgery, radiation and multi-agent chemotherapy have im...
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma G protein-coupled receptors (GPCRs) represent the larges...
Role of Transcription Factor ADP-ribosylation in Breast Cancer Biology
Project Summary/Abstract The molecular heterogeneity of cancers poses a major hurdle for treatment and drug discovery efforts. Previous studies have addressed this challenge by cha...
Roles of Coactivator-Associated Arginine Methyltransferase 1 in B cell activation and lymphomagenesis
PROJECT SUMMARY Follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL) are the most common germinal center (GC)- derived Non-Hodgkin B cell lymphomas (BCLs). Although i...
Developing and Testing a Digital Toolkit to Improve Colorectal Cancer Screening Rates in Federally Qualified Health Centers
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer death in the United States. National guidelines recommend that average risk people receive regular CRC...
HER2-mediated delivery of cytotoxic agents in solid tumors
PROJECT SUMMARY ERBB2/HER2 is a receptor tyrosine kinase (RTK) that is amplified/overexpressed in 15-20% of breast and gastroesophageal cancers, for which anti-HER2 therapy is now...
Investigating the roles of extracellular cGAMP and harnessing it for cancer treatment
PROJECT SUMMARY The goal of cancer immunotherapy is to awaken the body’s anti-tumoral immune response to fight against all cancers in all patients. Our lab recently identified a ke...
Optimizing Therapeutic STING Agonism in Triple Negative Breast Cancer
PROJECT SUMMARY Despite the therapeutic promise of STING agonists in cancer, first in human studies have been hampered by lack of precision therapy and issues with drug delivery. M...
Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...
A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable HCC Patients
SUMMARY Surgical resection is curative in hepatocellular carcinoma (HCC). Unfortunately, surgical cases often suffer from early recurrence (up to 50% in two years), which leads to...
Gain-of-function mutant p53 and metabolic reprogramming in colorectal cancer
Tumor suppressor p53 plays a central role in tumor prevention. p53 is frequently mutated in human cancer, including colorectal cancer (CRC). Many mutant p53 (mutp53) proteins not o...
A Multi-pronged Computational Approach to Advance Kinase Drug Discovery
Project Summary/Abstract In recent years, computing speed has exponentially increased; however, the potential of computational ap- proaches to accelerate drug discovery has not bee...
Epigenetic Control and Genome Organization
OVERALL PROGRAM SUMMARY Gary Stein and Janet Stein, Program Directors Our Program Project is a thematically, experimentally and operationally integrated multidisciplinary team appr...
Project 1: Mitotic Gene Bookmarking as an Epigenetic Mechanism to Maintain the Mammary Epithelial Phenotype
PROJECT 1 | SUMMARY Mechanisms underlying the epithelial to mesenchymal transition (EMT)—a normal developmental process and an early event at the onset of epithelium-derived cancer...
Project 2: Bromodomains as Epigenetic Modulators of Endocrine Responsiveness in ER+ Breast Cancer
PROJECT 2: SUMMARY Breast cancer (BCa) ranks among the leading causes of cancer death in women worldwide. Estrogen Receptor alpha positive tumors (ER+) are the most common subtype...
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
SUMMARY Long non-coding RNAs (lncRNAs) are epigenetic regulators of the chromatin organization supporting cancer cell activities. There is a gap in the literature identifying the c...
Administration and Coordination Core
SUMMARY/ABSTRACT Administration and Coordination Core Gary Stein, Core Leader; Janet Stein, Co-Leader The Administration and Coordination Core will provide leadership, and administ...
Experimental Integration, Design and Analysis Core
Summary: Experimental Integration, Design and Analysis Core The Experimental Integration, Design, and Analysis (EIDA) Core is an essential component of the program project that is...