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20,252 grants found
Showing 18,741 – 18,760 of 20,252 grants
Exploring novel SRC-regulated pathways in IDH mutant intrahepatic cholangiocarcinoma
PROJECT SUMMARY/ABSTRACT Intrahepatic cholangiocarcinoma (ICC) is a highly lethal form of liver cancer which has been rising in incidence worldwide and carries a prognosis of under...
Mechanisms of adhesion and invasion in hyaluronic acid matrices
PROJECT SUMMARY/ABSTRACT Hyaluronic acid (HA) is the most abundant component of the human brain, where it serves essential structural, mechanical, and cell-instructive functions. A...
Post-doctoral Training Program in Cancer Metabolism and Tumor-host Interactions
Rutgers Cancer Institute of New Jersey (RCINJ) provides an outstanding environment for training in basic, clinical, behavioral or population-based cancer research and brings togeth...
Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes
Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ≥65-years, ≥1-year post- treatment) have clinically significant depression. Presently, 64% of cancer...
Relaxed Polymerase Pausing as a Driver of Epigenetic Plasticity and Cancer Cell Invasion
Project Summary The development of distant metastases accounts for a significant proportion of breast cancer mortality; as many as 30% of patients initially diagnosed at an early s...
Targeting the autophagy-lysosome system to block pancreatic cancer
PROJECT SUMMARY Cancer cells co-opt autophagy - an evolutionarily conserved cellular recycling pathway - to maintain metabolic fitness. Prior studies have shown that Pancreatic Duc...
Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome
ABSTRACT While the outcomes for children with acute lymphoblastic leukemia (ALL) have improved dramatically over the past four decades, major challenges remain including the burden...
Defining the role of BARD1 in nucleosomal ubiquitylation
PROJECT SUMMARY BARD1 (BRCA1-Associated RING Domain protein-1) is an essential partner of the breast and ovarian cancer tumor-suppressor protein, BRCA1, and is included in a panel...
Elucidating Human Leukemia and T Cell Interactions within the Tumor Microenvironment
Project Summary/Abstract Leukemic relapse remains the major obstacle to successful allogeneic stem cell transplantation (allo-SCT). Here, donor lymphocyte infusion (DLI) seeks to r...
Expanding the scope of protein degradation and stability using chemoproteomic platforms
Targeted protein degradation (TPD) has arisen as a powerful drug discovery platform for tackling the undruggable proteome by targeting specific proteins for proteasomal degradation...
T cell expressed miR-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the second deadliest cancerglobally and has the third-highest incidenceand mortality rate of all cancers in the United States. P...
Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults
Project Summary Although smoking prevalence has declined to 13.7% among U.S. adults, smoking rates are much higher among socioeconomically disadvantaged adults. Lung cancer, which...
The Adenosinergic Pathway in Tumor-derived Exosomes
PROJECT SUMMARY/ABSTRACT Tumor cells produce and release large numbers of extracellular vesicles (EVs). A subset of small (30-150 nm) EVs derived from the endocytic compartment of...
Modeling cancer risk and environmental and socio-spatial exposures using residential histories
In many studies on the risk of disease, investigators analyze the spatial patterns of health outcomes and evaluate residential environmental exposures at the time of study enrollme...
Molecular Pathogenesis and Therapy of Systemic Histiocytic Neoplasms
Project Summary Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage that include Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Juven...
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
ABSTRACT Clonal hematopoesis (CH) defined as the presence of acquired mutations detectable in peripheral blood of normal healthy individuals without hematologic malignancies (HM) h...
Elucidating pro-metastatic collagen modifying activities of lysyl hydroxylase 2
As they progress, malignant tumors accumulate cross-linked collagen fibrils that enhance matrix stiffness, thereby activating collagen receptors that trigger cancer cell invasion a...
Lung Resident Mesenchymal Cells in the Pre-Metastatic Niche Formation
PROJECT SUMMARY/ABSTRACT Metastatic disease remains the major cause of cancer-related death. Among the vital organs to which solid tumors metastasize, the lung is one of the most c...
Targeting replication stress signaling to overcome immune evasion in small cell lung cancer
New therapeutic strategies are urgently needed to improve immune checkpoint blockade (ICB) therapy in small cell lung cancer (SCLC). SCLCs rely heavily on the replication stress re...
Mechanistic maps of adaptive responses to therapeutic stress to optimize combination therapies.
Summary. In triple-negative breast cancer and high-grade serous ovarian cancer, the emergence of resistance to therapy is virtually inevitable and contributes to dismal long-term p...