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20,252 grants found
Showing 18,701 – 18,720 of 20,252 grants
Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...
Automated Assessment for Robotic Suturing Utilizing Deep Learning Algorithms
ABSTRACT Medical errors are the third leading cause of death in the US at a cost of $20 billion annually. Surgical complications account for a third of these deaths and cost. Surgi...
Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapy
Abstract: Immunotherapy using programmed death 1 receptor (PD-1) blockade, either alone or in combination with existing therapies, has been proven to significantly improve survival...
[18F]-AraG -PET imaging to evaluate immunological response to checkpoint inhibitor therapy (CKI) in patients with advanced solid tumors
Contact PD/PI: Kummar, Shivaani PROJECT SUMMARY/ABSTRACT Immunotherapy, specifically checkpoint inhibitor (CKI) therapy, has resulted in dramatic and sustained tumor responses in p...
Targeting Lipid Metabolism in Colorectal Cancer
PROJECT SUMMARYMetastasis is the main cause of death from solid tumors including colorectal cancer (CRC). Our long-term goal is to develop more selective therapeutic options to pre...
Effectiveness and implementation of a health system intervention to improve quality of cancer care for rural, underserved patients
PROJECT SUMMARY There is growing evidence that limited access to high-quality cancer treatment is one of the main drivers of higher cancer mortality rates among rural cancer patien...
Leveraging deep learning for markerless motion management in radiation therapy
Leveraging deep learning for markerless motion management in radiation therapy Project Summary Organ motion is a predominant limiting factor for the maximum exploitation of modern...
Integrative single cell analyses of inflammation-derived circulating hybrid cells to identify aggressive disease
PROJECT SUMMARY The lifetime risk for acquiring colorectal cancer (CRC) is 7%, with an astounding rate of disease recurrence in 32% of newly diagnosed patients after their “success...
Profilin biology in breast cancer
Breast cancer the most frequently diagnosed non-skin cancer in women, ranks second among cancer deaths in women in the United States. The vast majority of these deaths are due to m...
Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis
ABSTRACT Gastric cancer (GC) is the fifth most common malignancy and the third most lethal cancer worldwide, with a 5-year survival rate of 5-10% in advanced stages. The long-term...
Can a subset of patients with HER2+ metastatic breast cancer be cured?
PROJECT SUMMARY Because of the development of highly effective HER2-targeted therapies over the past two decades, most patients now diagnosed with stage I-III HER2+ breast cancer (...
Elucidating the impact of DNA hypomethylation on genome organization and anti-tumor transcriptional programs
PROJECT SUMMARY This proposed research career development program seeks to investigate the impact of DNA hypomethylation on genome organization and the mechanisms by which it drive...
Changing Contraceptive Patterns and Ovarian Cancer Risk
ABSTRACT Contraceptive patterns are changing and the implications for ovarian cancer risk are unknown. Oral contraceptives (OCs), which are an established protective factor for ova...
Investigating Transcriptional Elongation and Nuclear RNA Surveillance in Melanoma
Project Summary Metastatic melanoma, a cancer derived from pigment-producing melanocytes, is the deadliest type of skin cancer. Metastatic melanoma that is refractory or resistant...
Understanding and targeting MAPK pathway activation in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)
Project Abstract Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft tissue sarcomas that occur in distinct clinical settings: neurofibrom...
Stem Cell-based Platform for Targeted Enzyme/Prodrug Therapy of Recurrent Ovarian Cancer
Project Summary: Ovarian cancer (OC) is associated with the highest mortality rate of all gynecologic malignancies in the United States. The low rate of survival is mainly due to t...
Interplay between tumor and microenvironment in bone metastasis
Prostate cancer (CaP) is the most commonly diagnosed cancer and the second leading cause of cancer death in men over the age of fifty. Bone is the primary site of metastasis in pat...
Credentialing Models of Invasive Lobular Breast Cancer for Translational Research
Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after the more common invasive ductal breast cancer (IDC). In 2020, ILC will af...
Efficacy of a Mindfulness-Based Stress Management Program for Allogeneic HCT Caregivers
PROJECT SUMMARY/ABSTRACT Caring for an allogeneic hematopoietic stem cell transplant (HCT) patient is a significant responsibility, involving a commitment to be available 24/7 up t...
Mechanisms of Epigenetic Plasticity in PDAC
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human cancers and in ~95% of cases driven by oncogenic mutations of Kras. Unfortunately, attempts to directly inhi...