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20,252 grants found
Showing 18,681 – 18,700 of 20,252 grants
Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem
PROJECT SUMMARY Ovarian cancer is a silent killer that strikes with few, if any, symptoms. By the time a woman knows she has it, the cancer is often advanced and the outlook grim....
Viscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosity
Cell motility is a key step in the metastatic cascade of events, as it enables cancerous cells dissociating from a primary tumor to navigate through interstitial tissues and ultima...
Understanding Efficacy and Fe(II)-Promoted Activation of 1,2,4-Trioxolanes in Cancer
Project Summary/Abstract Summary: Precision cancer medicine’s foundation lies in discovering and exploiting pathways that are essential for cancer cells, but dispensable for cancer...
Changing Contraceptive Patterns and Ovarian Cancer Risk
ABSTRACT Contraceptive patterns are changing and the implications for ovarian cancer risk are unknown. Oral contraceptives (OCs), which are an established protective factor for ova...
Joint receptor and protein expression immunophenotyping through split-pool barcoding
Single-cell immune repertoire sequencing can provide invaluable information about the response of the adaptive immune system to disease and therapy. However, existing approaches fo...
Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome
ABSTRACT While the outcomes for children with acute lymphoblastic leukemia (ALL) have improved dramatically over the past four decades, major challenges remain including the burden...
Mechanisms of Epigenetic Plasticity in PDAC
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human cancers and in ~95% of cases driven by oncogenic mutations of Kras. Unfortunately, attempts to directly inhi...
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have revolutionized lung cancer clinical practice. Lung adenocarcinomas harbor frequent mutations/amplifications/fusi...
Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...
Exploring novel SRC-regulated pathways in IDH mutant intrahepatic cholangiocarcinoma
PROJECT SUMMARY/ABSTRACT Intrahepatic cholangiocarcinoma (ICC) is a highly lethal form of liver cancer which has been rising in incidence worldwide and carries a prognosis of under...
Understanding and targeting MAPK pathway activation in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)
Project Abstract Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft tissue sarcomas that occur in distinct clinical settings: neurofibrom...
A Novel Microbiome-Based Immune-Modulator that Potentiates Cancer Checkpoint Therapy
Project Summary The goal of this project is to develop a novel oral drug, R-5780, which engages microbiome-associated Pattern Recognition Receptors (PRRs) to enhance the activity o...
Longitudinal Proteomic and Metabolomic Predictors of Pancreatic Cyst Malignant Progression and Early Stage Pancreatic Cancer
Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDAC) has a dire prognosis mainly due to its late diagnosis. It is vital to identify early-stage PDAC and its precursors....
Human papillomavirus in HIV associated lung cancers
SUMMARY In recent years, the incidence of AIDS-defining cancers has dramatically decreased due to the HAART therapy. In contrast, the incidence of the non-AIDS-defining cancers (NA...
Targeting allosteric scaffolding functions of Aurora kinase A in cancer
ABSTRACT Neuroblastoma is the most common solid tumor in infants. About 25% of patients have high-risk neuroblastoma, a devastating disease with poor prognosis and few treatment op...
The selective advantage of mismatch repair loss in colonic stem cells
Project Summary Lynch syndrome (LS) is a hereditary disease that predisposes patients to colorectal, endometrial, ovarian and other cancers. LS is caused by inherited mutations in...
Synthetic epigenetic circuits: tunable cell fate switches controlled by dynamic and combinatorial inputs
PROJECT SUMMARY Cellular differentiation is controlled by epigenetic regulatory systems that integrate multiple sensory inputs over time to direct long-term cell fate decisions. Ha...
Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer
Project Summary Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer Women with germline mutations in BRCA1 and BRCA2 (BRCA carriers) are at high ris...
Predicting sensitivity and resistance in RET-driven cancers
Selpercatinib (LOXO-292) is a highly active selective RET inhibitor explored on an ongoing registrational program (LIBRETTO-001 phase 1/2 trial) in RET-dependent cancers (US FDA ap...
Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial
PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is n...