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20,252 grants found
Showing 18,661 – 18,680 of 20,252 grants
Can a subset of patients with HER2+ metastatic breast cancer be cured?
PROJECT SUMMARY Because of the development of highly effective HER2-targeted therapies over the past two decades, most patients now diagnosed with stage I-III HER2+ breast cancer (...
A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable HCC Patients
SUMMARY Surgical resection is curative in hepatocellular carcinoma (HCC). Unfortunately, surgical cases often suffer from early recurrence (up to 50% in two years), which leads to...
Does obesity influence protein quality control in endometrial cancer?
PROJECT SUMMARY/ABSTRACT Research Project: Excess body weight is a contributing factor in up to 20% of all cancer deaths in women. In particular, endometrial cancer (EC) incidence...
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences
Project Abstract Live cell reporters of genetic changes in stiff vs soft surroundings – causes & consequences Solid tumors are often palpably stiff and more constrained in 3D g...
Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem
PROJECT SUMMARY Ovarian cancer is a silent killer that strikes with few, if any, symptoms. By the time a woman knows she has it, the cancer is often advanced and the outlook grim....
Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Per the FOA, this section is not required. The research supplement proposal does not change the activities of the parent award.
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Per the FOA, this section is not required. The research supplement proposal does not change the activities of the parent award.
Relaxed Polymerase Pausing as a Driver of Epigenetic Plasticity and Cancer Cell Invasion
Project Summary The development of distant metastases accounts for a significant proportion of breast cancer mortality; as many as 30% of patients initially diagnosed at an early s...
Enabling remote medical physics services for medical accelerator quality assurance through a novel, table-top imaging device
Executive Summary Radiation Therapy is an effective component of the treatment strategy for patients suffering from cancer. Advanced techniques such as intensity modulated radiatio...
Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer
Project Summary Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer Women with germline mutations in BRCA1 and BRCA2 (BRCA carriers) are at high ris...
Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes
Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ≥65-years, ≥1-year post- treatment) have clinically significant depression. Presently, 64% of cancer...
An exploration of pathways for exercise referrals in rural cancer community settings
PROJECT SUMMARY/ABSTRACT There is growing evidence that limited access to high-quality cancer treatment is one of the main drivers of higher cancer mortality rates among rural canc...
Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution
ABSTRACT: Poly (ADP-ribose) polymerase inhibitors (PARPi’s) have emerged as important therapeutic agents targeting a broadening class of gene mutations approved for treatment of br...
Developing and credentialing murine models of ILC
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-23-045 and under the parent award R01CA252378 and the Oncology Models...
Modeling cancer risk and environmental and socio-spatial exposures using residential histories
In many studies on the risk of disease, investigators analyze the spatial patterns of health outcomes and evaluate residential environmental exposures at the time of study enrollme...
Developing and Testing a Digital Toolkit to Improve Colorectal Cancer Screening Rates in Federally Qualified Health Centers
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer death in the United States. National guidelines recommend that average risk people receive regular CRC...
Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis
ABSTRACT Gastric cancer (GC) is the fifth most common malignancy and the third most lethal cancer worldwide, with a 5-year survival rate of 5-10% in advanced stages. The long-term...
Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes
Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ≥65-years, ≥1-year post- treatment) have clinically significant depression. Presently, 64% of cancer...