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20,252 grants found
Showing 18,621 – 18,640 of 20,252 grants
Gain-of-function mutant p53 and metabolic reprogramming in colorectal cancer
Tumor suppressor p53 plays a central role in tumor prevention. p53 is frequently mutated in human cancer, including colorectal cancer (CRC). Many mutant p53 (mutp53) proteins not o...
Development of Advanced Oligonucleotides for Glioblastoma Therapeutics
PROJECT SUMMARY Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite significant progress being made in characterizing the genet...
DNA Methylation Markers, Genes and Breast Cancer Risk
PROJECT SUMMARY Genome-wide association studies (GWAS) have identified common variants in ~200 genetic loci associated with breast cancer risk. However, it is difficult to translat...
Mechanism of Transformation in T-Cell Lymphomas: Identification of Therapeutic Targets
Project Summary T-cell lymphomas (TCL) are a highly aggressive and heterogeneous group of non-Hodgkin lymphomas derived from post-thymic mature T- and NK-cells. Limited understandi...
Mechanisms of metabolic stress-induced transcriptional regulation in prostate cancer
Metastatic prostate cancer (PCa) remains a major clinical challenge. Although androgen deprivation therapy (ADT) is effective in treating PCa, majority of the patients quickly deve...
Targeting the autophagy-lysosome system to block pancreatic cancer
PROJECT SUMMARY Cancer cells co-opt autophagy - an evolutionarily conserved cellular recycling pathway - to maintain metabolic fitness. Prior studies have shown that Pancreatic Duc...
Developing newly combined therapeutic strategies for mature B cell lymphoma
While PD-1 blockade is effective in relapsed or refractory classical Hodgkin lymphoma (cHL) and in a subset of diffuse large B cell lymphomas (DLBCL) patients, a majority of B cell...
Interplay between tumor and microenvironment in bone metastasis
Prostate cancer (CaP) is the most commonly diagnosed cancer and the second leading cause of cancer death in men over the age of fifty. Bone is the primary site of metastasis in pat...
Genetic Predisposition to Chronic Lymphocytic Leukemia (CLL)
Project Summary CLL is the most common leukemia of adults in North America, with about 20,000 new cases per year, and remains incurable. Although a small subset of patients has ind...
Development of an NTSR1-Targeted Radiotherapeutic for Colorectal Cancer
Objective: More effective treatment options are needed across all clinical stages of colorectal cancer (CRC), from eliminating residual disease after surgery, improving surgical ca...
Investigating the role of EZH2 as a therapeutic target in colorectal cancers
Abstract The Polycomb Repressive Complex 2 (PRC2) is a highly conserved developmental regulator that maintains cellular identity by dynamically silencing key genes involved in diff...
Exploring the Role of Drp1 in Colorectal Cancer
Abstract - Exploring the Role of Drp1 in Colorectal Cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Approximately 150,000 new c...
Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia
PROJECT SUMMARY Relapse is the major cause of cancer related mortality in children with leukemia. Despite improvements in overall survival for children with B-cell progenitor acute...
Defining the regulation of UHRF1 and DNMT1 for maintenance of the epigenome
PROJECT SUMMARY In multicellular organisms, methylation of DNA on the 5’ carbon of cytosine helps ensure proper gene expression. Methylation occurs symmetrically on both DNA strand...
The Pediatric Advanced Cancer Experience (PACE): Measuring Quality of End-of-Life Care for Children with Cancer
PROJECT SUMMARY Although cure rates for childhood cancer have increased over several decades, cancer remains the leading cause of non-accidental death in children. Yet, there are n...
Mechanisms of adhesion and invasion in hyaluronic acid matrices
PROJECT SUMMARY/ABSTRACT Hyaluronic acid (HA) is the most abundant component of the human brain, where it serves essential structural, mechanical, and cell-instructive functions. A...
DNA Damage and Immunogenicity in Ewing Sarcoma
The goal of this career development award is for the applicant to expand her knowledge and technical expertise in tumor immunology and bioinformatic analyses in order to apply thes...
Estrogen receptor fusions genes as drivers of endocrine resistance in breast cancer
Anti-estrogen therapy is key to the prevention and treatment of estrogen receptor (ER, ESR1) positive breast cancer, but therapy resistance occurs in up to a half of cases resultin...
Dynamic 3D chromatin remodeling in acute leukemia - Resubmission - 1
ABSTRACT Recent advances in chromatin conformation capture techniques have revolutionized our understanding of chro- matin organization and have provided novel insights at an unpre...
Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis
N-methyltransferase (NNMT), a key enzyme in the NAD+ salvage pathway with unclear functions, is expressed highly and specifically in basal-like breast cancer (BLBC). We found that...