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20,252 grants found
Showing 18,601 – 18,620 of 20,252 grants
Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation
PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast ca...
The Identity of the Notch Ankyrin Repeat Domain as a Determinant of Isoform-Specific Notch Signaling
Project Summary/Abstract: The Notch signaling pathway is a crucial regulator of development and cell differentiation in almost all animal organs and tissues. The Notch receptor is...
Targeting allosteric scaffolding functions of Aurora kinase A in cancer
ABSTRACT Neuroblastoma is the most common solid tumor in infants. About 25% of patients have high-risk neuroblastoma, a devastating disease with poor prognosis and few treatment op...
New Hybrid Molecular Modalities Comprised of DNA-Origami and Interfering Peptides as Inhibitors of Protein-Protein Interactions
PROJECT SUMMARY/ABSTRACT: New molecular modalities to target sites of protein-protein interaction with high affinity and specificity are desperately needed in cancer treatment. Blo...
Expanding the scope of protein degradation and stability using chemoproteomic platforms
Targeted protein degradation (TPD) has arisen as a powerful drug discovery platform for tackling the undruggable proteome by targeting specific proteins for proteasomal degradation...
Epigenetic regulators of subtype plasticity in bladder cancer
Project Summary/Abstract Bladder cancer can be subdivided into two categories: non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). NMIBC is treate...
TRANSCRIPTIONAL REPROGRAMMING OF ESR1 MUTANT BREAST CANCER IN METASTASIS AND TREATMENT RESISTANCE
Project Summary Up to 1 in 8 women in the United States will develop invasive breast cancer in their lifetime, with 70-80% of cases being estrogen receptor positive (ER+). These ca...
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
ABSTRACT Clonal hematopoesis (CH) defined as the presence of acquired mutations detectable in peripheral blood of normal healthy individuals without hematologic malignancies (HM) h...
Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor Liposome
ABSTRACT The prognosis for patients with advanced stage ovarian or pancreatic cancer has remained dismal for decades. The poor response rates result, in part, from resistance to sa...
Dissecting new mechanisms of lysosome quality control in health and disease
PROJECT SUMMARY Lysosomes function as critical nodes for macromolecular recycling, metabolic rewiring, and pro-growth signaling in cells. Accordingly, defects in lysosome function...
Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma
Sarcomatoid renal cell carcinoma (sRCC) represents an aggressive group of renal epithelial tumors characterized by histopathological features of epithelial–mesenchymal plasticity (...
Novel TYRO3 inhibitors for treatment of cancer
TYRO3 is a member of the TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases. All three family members are aberrantly expressed in cancer cells, where they function to prom...
Targeting Lipid Metabolism in Colorectal Cancer
PROJECT SUMMARYMetastasis is the main cause of death from solid tumors including colorectal cancer (CRC). Our long-term goal is to develop more selective therapeutic options to pre...
Harnessing Rare Variants for Tumor Classification
Abstract This project concerns how to extract clinically actionable information for diagnostic purposes from mutational patterns observed from tumor sequencing panels that are incr...
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin state
PROJECT SUMMARY Recent whole-exome sequencing studies in human cancer and neurodevelopmental disorders have unmasked frequent mutations in genes encoding chromatin regulatory prote...
Genetic Determinants of Evolutionary Trajectories and Clinical Course in Pancreatic Cancer
PROJECT SUMMARY Genetic intratumoral heterogeneity (gITH) has been associated with cancer progression and is thought to be a major contributor to treatment resistance. However, the...
Design and Application of Cationic Nanocarriers to Inhibit Breast Cancer Progression in Primary and Metastatic Sites
PROJECT SUMMARY Triple-negative breast cancer (TNBC) is characterized by the lack of estrogen/progesterone receptors and human epidermal growth factor receptor 2 (HER2) expression...
Two photon fluorescence microscopy for dermatologic surgery and biopsy
Medicare reimburses over 5 million biopsies resulting in 1.5 million surgical procedures annually for nonmelanoma skin cancer (NMSC). Despite its burden on the health care system,...
Imaging and manipulating oncoprotein phase separation and compartmentalization
Abstract MYC oncoproteins including c-Myc and MYCN are major drivers of human tumorigenesis. Expression of MYC is deregulated and enhanced in many types of human cancer. For instan...
A novel determinant of prostate cancer growth
Project Summary/Abstract Prostate cancer (CaP) will cause the deaths of more than 33,000 American men in 2020 because systemic treatments for metastatic CaP fail. Actionable target...