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20,252 grants found
Showing 18,581 – 18,600 of 20,252 grants
Molecular Pathogenesis and Therapy of Systemic Histiocytic Neoplasms
Project Summary Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage that include Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Juven...
Regulation of DGAT - dependent lipogenesis in colonic epithelial growth
Abstract Obesity is characterized by systemic lipid accumulation, inflammation, and enhanced tumorigenesis in different tissues, including colon. With obesity, intracellular lipid...
Diversity Supplement Grant: TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences
Project Summary/Abstract Aneuploidy is defined as the existence of an abnormal number of chromosomes in a cell, and it has long been a defining characteristic of cancers. 90% of al...
A Novel Microbiome-Based Immune-Modulator that Potentiates Cancer Checkpoint Therapy
Project Summary The goal of this project is to develop a novel oral drug, R-5780, which engages microbiome-associated Pattern Recognition Receptors (PRRs) to enhance the activity o...
Contribution of Nuclear S1P Signaling to Microtubule Targeting Agent-Induced Changes in Transcriptional Activity in Human iPS-SNs
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...
Elucidating the impact of DNA hypomethylation on genome organization and anti-tumor transcriptional programs
PROJECT SUMMARY This proposed research career development program seeks to investigate the impact of DNA hypomethylation on genome organization and the mechanisms by which it drive...
Novel TYRO3 inhibitors for treatment of cancer
TYRO3 is a member of the TAM (TYRO3, AXL, MERTK) family of receptor tyrosine kinases. All three family members are aberrantly expressed in cancer cells, where they function to prom...
Optimizing Dual-Targeted and Dual-Armored CAR T Cells for Small Cell LungCancer
ABSTRACT A patient's own T cells can be modified using gene therapy technology to express receptors, termed chimeric antigen receptors or CARs, which allow these immune T cell...
Differential resistance mechanisms to monofunctional vs bifunctional alkylating agents in glioma
Project Summary Resistance to alkylating agents, including monofunctional temozolomide (TMZ) and bifunctional CCNU, remains a major obstacle to improving outcomes for patients with...
Stem Cell-based Platform for Targeted Enzyme/Prodrug Therapy of Recurrent Ovarian Cancer
Project Summary: Ovarian cancer (OC) is associated with the highest mortality rate of all gynecologic malignancies in the United States. The low rate of survival is mainly due to t...
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONS
PROJECT SUMMARY Mutations that inactivate DNA repair factors increase genome instability and cancer susceptibility. Predicting the phenotypic effects of mutations is confounded by...
Methods for improved detection of activated molecular pathways in cancer
PROJECT SUMMARY/ABSTRACT Studying tumors by quantifying gene expression via RNA-sequencing (RNA-seq) has proven crucial to elucidating their active biological pathways and processe...
Contribution of ERa/PR Crosstalk to Endocrine Therapy Resistance in the Context of ERa-Y537S
PROJECT SUMMARY/ABSTRACT Half of estrogen receptor (ERα)-positive breast cancer patients treated with endocrine therapies manifest intrinsic or acquired therapy resistance. One-thi...
Elucidating the Regulation and Requirement of the NAD salvage pathway in CD8+ T Cell Exhaustion
Project Summary The development of checkpoint based cancer immunotherapy has revolutionized cancer treatment in the last decade. Although many otherwise untreatable patients have s...
Human papillomavirus in HIV associated lung cancers
SUMMARY In recent years, the incidence of AIDS-defining cancers has dramatically decreased due to the HAART therapy. In contrast, the incidence of the non-AIDS-defining cancers (NA...
Effectiveness and implementation of a health system intervention to improve quality of cancer care for rural, underserved patients
PROJECT SUMMARY There is growing evidence that limited access to high-quality cancer treatment is one of the main drivers of higher cancer mortality rates among rural cancer patien...
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma G protein-coupled receptors (GPCRs) represent the larges...
Lymph node regulation of metastatic fitness and reemergence
PROJECT SUMMARY Metastasis is the most dangerous stage of cancer, responsible for the vast majority of breast cancer-related deaths. Currently, we have no treatments that target me...
Role of Transcription Factor ADP-ribosylation in Breast Cancer Biology
Project Summary/Abstract The molecular heterogeneity of cancers poses a major hurdle for treatment and drug discovery efforts. Previous studies have addressed this challenge by cha...