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20,252 grants found
Showing 1,841 – 1,860 of 20,252 grants
Cultural and Linguistic Adaptation of a Breast Reconstruction Decision Tool
PROJECT SUMMARY/ABSTRACT Breast reconstruction is a critical component of breast cancer treatment because it restores quality of life and body image after mastectomy. It has become...
Fecal microbial transplantation for chemotherapy behavioral side effects
PROJECT SUMMARY/ABSTRACT Mental side effects of chemotherapy reduce quality of life and treatment dosing, thereby increasing mortality. Current supportive care treatments are ineff...
Elucidating the role of hepatic ketogenesis in pancreatic cancer cachexia and recovery
PROJECT SUMMARY/ABSTRACT 80% of patients with Pancreatic Ductal Adenocarcinoma (PDAC) develop cachexia, which results in dispropor- tionate skeletal muscle mass loss, relative to c...
Dissecting the Role of Germline Genetics in RAS-Driven Cancers
PROJECT SUMMARY/ABSTRACT Most applications of genomics in modern oncology focus on somatic mutations acquired during tumor evolution and selecting drugs to target these tumor-speci...
Investigating the Roles of Pregnane X Receptor in Human Breast Cancers
Project Summary/Abstract Breast cancer is the second most common type of cancer diagnosed worldwide and is also the second leading cause of cancer-related deaths among women overal...
A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development
Project Summary The long-term objective of this project is to develop Dr. Romanos-Nanclares’s capacity to conduct studies that integrate dietary and lifestyle factors with multi-om...
Understanding and improving novel oncolytic viruses for pancreatic cancer
PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and accounts for upwards of 95% of all pancreatic cancers. With the...
Influence of Social Determinants of Health and Epigenomics on Psychological Symptom Cluster Severity
PROJECT SUMMARY/ABSTRACT The psychological symptom cluster is a common problem that impacts women receiving breast cancer treatment and is associated with several negative outcomes...
Building equity in cancer screening through research: The Siteman Catchment CSRN Hub
To bring equity principles to research and practice of cancer screening and early detection, we will build a CSRN ACCESS Hub at Siteman Cancer Center. Improving early detection is...
A Chemoproteomic Approach to Identify Molecular Glues for Targeted Cancer Therapy
Project Summary / Abstract Research Plan: Targeted protein degradation using molecular glues - small molecules that bring a protein of interest in proximity to an E3 ligase - emerg...
HFH-MSU CSRN ACCrual Enrollment and Screening Site
Metropolitan-Detroit based Henry Ford Health (HFH) has over 20-years of experience in the successful conduct of multi-site cancer screening and prevention clinical trials research....
New Chemical Tools for Covalent Drug Discovery
ABSTRACT Development of covalent drugs for cancer therapy relies heavily on identifying the full spectrum of on- and off- targets within the proteome, along with the specific site...
Harnessing Exercise to Enhance Immunity and Boost Immunotherapy Outcomes in Patients with Lung Cancer
PROJECT SUMMARY Overview: 1.8 million people die of lung cancer each year across the globe. Immunotherapy, particularly using immune checkpoint inhibitors (ICIs), has revolutionize...
Urology practice consolidation and care for men with prostate cancer
PROJECT SUMMARY Management of prostate cancer remains a daunting challenge. Many men with prostate cancer will not die from it—even without any intervention—either due to competing...
Cancer Neuroscience - An Emerging Hallmark
ABSTRACT Accelerated understanding of nervous system functions and cancer has led to cancer neuroscience evolving into a new frontier of discovery in cancer biology and therapy. Th...
Expanding access to colorectal cancer screening through community pharmacies: The PharmFIT study
Project Abstract (Summary) Medically underserved populations are disproportionately affected by screen-preventable cancers, such as colorectal cancer (CRC). Entities such as the Un...
Determining the Role of SOX8 in Myogenesis and Rhabdomyosarcomagenesis
Project Summary/Abstract Rhabdomyosarcoma (RMS) is a common aggressive pediatric soft tissue sarcoma. Despite many rigorous clinical trials, the survival rate for high-risk patient...
Identifying the Mechanism of Resistance to Immunotherapy in Merkel Cell Carcinoma (for Zachary Reinstein)
Project Summary/Abstract Merkel cell carcinoma (MCC) is the most aggressive and fatal cancer on a case-by-case basis with rapidly rising incidence. Approximately 80% of MCC cases a...
Intraoperative Molecular Imaging of Metastatic Osteosarcoma with 111In-dinutuximab-IR800
Intraoperative identification of metastatic lesions is challenging due to unpredictable locations and coverage by normal tissue. Intraoperative molecular imaging (IMI) uses targete...
Translation Rewiring Underlines Drug Resistance to Lethal Targeted Ribosome Biogenesis Therapeutics in Cancer
Project Summary/Abstract Increased ribosome biogenesis is a hallmark of cancer and reflects the increased and pervasive protein synthetic needs of the cancer cells. Targeting this...