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20,252 grants found
Showing 18,561 – 18,580 of 20,252 grants
SMARCB1 regulated SWI/SNF complex function in Malignant Rhabdoid Tumors
PROJECT SUMMARY A research program will be undertaken to study SMARCB1-regulated SWI/SNF complex function in malignant rhabdoid tumors. Over the past few years, major cancer genome...
Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.
PROJECT SUMMARY/ABSTRACT Immunotherapy induces durable remissions in a subset of patients with highly mutated cancers. However, most cancers are modestly mutated and fail to respon...
Defining the regulation of UHRF1 and DNMT1 for maintenance of the epigenome
PROJECT SUMMARY In multicellular organisms, methylation of DNA on the 5’ carbon of cytosine helps ensure proper gene expression. Methylation occurs symmetrically on both DNA strand...
Modeling cancer risk and environmental and socio-spatial exposures using residential histories
In many studies on the risk of disease, investigators analyze the spatial patterns of health outcomes and evaluate residential environmental exposures at the time of study enrollme...
Epigenetic Control and Genome Organization
OVERALL PROGRAM SUMMARY Gary Stein and Janet Stein, Program Directors Our Program Project is a thematically, experimentally and operationally integrated multidisciplinary team appr...
Project 1: Mitotic Gene Bookmarking as an Epigenetic Mechanism to Maintain the Mammary Epithelial Phenotype
PROJECT 1 | SUMMARY Mechanisms underlying the epithelial to mesenchymal transition (EMT)—a normal developmental process and an early event at the onset of epithelium-derived cancer...
Project 2: Bromodomains as Epigenetic Modulators of Endocrine Responsiveness in ER+ Breast Cancer
PROJECT 2: SUMMARY Breast cancer (BCa) ranks among the leading causes of cancer death in women worldwide. Estrogen Receptor alpha positive tumors (ER+) are the most common subtype...
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer
SUMMARY Long non-coding RNAs (lncRNAs) are epigenetic regulators of the chromatin organization supporting cancer cell activities. There is a gap in the literature identifying the c...
Administration and Coordination Core
SUMMARY/ABSTRACT Administration and Coordination Core Gary Stein, Core Leader; Janet Stein, Co-Leader The Administration and Coordination Core will provide leadership, and administ...
Experimental Integration, Design and Analysis Core
Summary: Experimental Integration, Design and Analysis Core The Experimental Integration, Design, and Analysis (EIDA) Core is an essential component of the program project that is...
Mitochondrial heterogeneity as the origin of chemoresistance in pancreatic cancer
Summary Therapeutic resistance and tumor relapse present as major barriers to achieving a definitive cure for cancer. This challenge is especially relevant for patients with pancre...
Stem Cell-based Platform for Targeted Enzyme/Prodrug Therapy of Recurrent Ovarian Cancer
Project Summary: Ovarian cancer (OC) is associated with the highest mortality rate of all gynecologic malignancies in the United States. The low rate of survival is mainly due to t...
Regulation and function of exosomal cargo loading in cancer progression
Regulation and function of exosomal cargo loading in cancer progression Exosomes are 50-150 nm, endosome-derived, extracellular vesicles that are secreted by most cells. The exosom...
Immune Biomarker Assessment and Manufacturing Development for SQ3370-001, a first-in-human phase I dose-escalation clinical trial to test a novel treatment against advanced solid tumors
Abstract In 2018, the global incidence of new cancer diagnoses was estimated at over 18 million cases, and cancer- related deaths were estimated at over 9.6 million. Of these cases...
Changing Contraceptive Patterns and Ovarian Cancer Risk
ABSTRACT Contraceptive patterns are changing and the implications for ovarian cancer risk are unknown. Oral contraceptives (OCs), which are an established protective factor for ova...
Minibeam Radiation Therapy Enhanced Delivery of Nanoparticle Anticancer Agents to Pancreatic Cancer Tumors
PROJECT SUMMARY / ABSTRACT: Nanoparticles (NPs) hold great promise for delivering more effective and safer cancer treatment than the small molecule drugs that are commonly used. Th...
Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia
PROJECT SUMMARY Relapse is the major cause of cancer related mortality in children with leukemia. Despite improvements in overall survival for children with B-cell progenitor acute...
Mechanistic Studies of a Novel Vulnerability in Pediatric Cancer
Project Abstract Rhabdoid tumors (RT) are aggressive and lethal cancers that occur in young children. These tumors are resistant to chemotherapy and have a five-year survival rate...
Elucidating the Regulation and Requirement of the NAD salvage pathway in CD8+ T Cell Exhaustion
Project Summary The development of checkpoint based cancer immunotherapy has revolutionized cancer treatment in the last decade. Although many otherwise untreatable patients have s...
Mechanisms regulating the formation of a pro-metastatic niche and tumor cell dormancy in the liver
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States. For patients with PDAC, metastasis is the major cause of...