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20,252 grants found
Showing 18,541 – 18,560 of 20,252 grants
Team-based Interdisciplinary Cancer Research Training Program
TEAM-BASED INTERDISCIPLINARY CANCER RESEARCH TRAINING PROGRAM PROJECT SUMMARY/ABSTRACT In advancing innovative ways to address complex cancer challenges, there is a growing trend t...
Developing novel CAR T cell designs using combinatorial antigen detection
PROJECT SUMMARY/ABSTRACT Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead an independent laboratory-based translational r...
Regulation and recognition of H3K79me
Project Summary/Abstract Patterns of dynamic post-translational modifications on histone proteins of nucleosomes regulate local and global eukaryotic gene expression by recruiting...
Roles of Coactivator-Associated Arginine Methyltransferase 1 in B cell activation and lymphomagenesis
PROJECT SUMMARY Follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL) are the most common germinal center (GC)- derived Non-Hodgkin B cell lymphomas (BCLs). Although i...
Mechanisms of tumor initiation upon disruption of the Rb/E2f interaction
ABSTRACT E2f (E2f1-8) transcription factors are critical regulators of cell cycle and their activity is physically regulated by Rb family proteins (Rb, p107 and p130). Disruption o...
Molecular mechanism of EGFRs protein-protein interaction inhibition by a grafted peptide in NSCLC
Project Summary: The long-term objective of this research project is to understand the role of dimerization in extracellular domains (ECD) of epidermal growth factor receptors (EGF...
Regulation of DGAT - dependent lipogenesis in colonic epithelial growth
Abstract Obesity is characterized by systemic lipid accumulation, inflammation, and enhanced tumorigenesis in different tissues, including colon. With obesity, intracellular lipid...
Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon Radiotherapy
Project Summary Radiotherapy (RT) aims to deliver tumoricidal dose to clinical target volume (CTV) while sparing organs at risk (OAR), for which proton and photon beams are natural...
Targeting replication stress signaling to overcome immune evasion in small cell lung cancer
New therapeutic strategies are urgently needed to improve immune checkpoint blockade (ICB) therapy in small cell lung cancer (SCLC). SCLCs rely heavily on the replication stress re...
Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia
PROJECT SUMMARY Relapse is the major cause of cancer related mortality in children with leukemia. Despite improvements in overall survival for children with B-cell progenitor acute...
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have revolutionized lung cancer clinical practice. Lung adenocarcinomas harbor frequent mutations/amplifications/fusi...
Viscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosity
Cell motility is a key step in the metastatic cascade of events, as it enables cancerous cells dissociating from a primary tumor to navigate through interstitial tissues and ultima...
Developing novel CAR T cell designs using combinatorial antigen detection
PROJECT SUMMARY/ABSTRACT Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead an independent laboratory-based translational r...
DNA Damage and Immunogenicity in Ewing Sarcoma
The goal of this career development award is for the applicant to expand her knowledge and technical expertise in tumor immunology and bioinformatic analyses in order to apply thes...
Mathematical Model-Guided Adoptive Immunotherapy in Bladder Cancer
Summary Bladder cancer is the fourth most common cancer in men and a leading cause of cancer mortality among men and women with the rates of bladder cancer incidents and bladder ca...
Mechanisms of tumor initiation upon disruption of the Rb/E2f interaction
ABSTRACT E2f (E2f1-8) transcription factors are critical regulators of cell cycle and their activity is physically regulated by Rb family proteins (Rb, p107 and p130). Disruption o...
BET degraders for improving colorectal cancer therapy
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the US. Developing novel and more effective CRC therapies is an unmet biome...
Defining the Critical Function and Regulation of NNMT in Breast Cancer Progression and Metastasis
N-methyltransferase (NNMT), a key enzyme in the NAD+ salvage pathway with unclear functions, is expressed highly and specifically in basal-like breast cancer (BLBC). We found that...
Dissecting the role of clonal evolution in NPM1-mutant AML
Project Summary/Abstract Candidate: I am a postdoctoral fellow in the lab of Dr. Ross Levine in the Human Oncology & Pathogenesis Program at Memorial Sloan Kettering Cancer Cen...
Quantitative Analyses of HER2 Upregulation in Luminal Breast Cancer in Response to Neoadjuvant Endocrine Therapy
Project Description Endocrine therapy provides significant improvement in long-term outcomes for patients with estrogen receptor- positive (ER+) breast cancer (BC), also known as l...