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20,252 grants found
Showing 18,521 – 18,540 of 20,252 grants
Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation
PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast ca...
Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis
ABSTRACT Gastric cancer (GC) is the fifth most common malignancy and the third most lethal cancer worldwide, with a 5-year survival rate of 5-10% in advanced stages. The long-term...
Mechanisms of metabolic stress-induced transcriptional regulation in prostate cancer
Metastatic prostate cancer (PCa) remains a major clinical challenge. Although androgen deprivation therapy (ADT) is effective in treating PCa, majority of the patients quickly deve...
Genetically faithful modeling of NUP98 rearrangement and co-alterations in acute myeloid leukemia
PROJECT SUMMARY Chromosomal translocations involving Nucleoporin 98 (NUP98) are observed in approximately 5% of pediatric acute myeloid leukemia (AML) and are associated with resis...
Mechanisms of adhesion and invasion in hyaluronic acid matrices
PROJECT SUMMARY/ABSTRACT Hyaluronic acid (HA) is the most abundant component of the human brain, where it serves essential structural, mechanical, and cell-instructive functions. A...
Synthetic epigenetic circuits: tunable cell fate switches controlled by dynamic and combinatorial inputs
PROJECT SUMMARY Cellular differentiation is controlled by epigenetic regulatory systems that integrate multiple sensory inputs over time to direct long-term cell fate decisions. Ha...
Analyzing the Hypersensitivity of MMR-deficient Colorectal Cancers to mTOR Inhibition and the Response of Cancer Stem Cells
Project Summary Mutations in DNA mismatch repair (MMR) genes are causative in Lynch Syndrome (LS) and defective MMR drives tumorigenesis in a significant proportion (15 - 20%) of s...
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy
PROJECT SUMMARY: Pancreatic ductal adenocarcinoma (PDA) will become the 2nd leading cause of cancer deaths in the United States by 2030. Most patients with PDA present with nonrese...
Targeting Epigenomic Regulators at the Replication Fork in PDAC
Pancreatic adenocarcinoma (PDAC) remains a therapeutic challenge, making the identification of new targets and development of novel treatment strategies for this disease of paramou...
Improving efficacy of radioiodine treatment of thyroid cancer
Patients with advanced thyroid cancer are frequently refractory to radioiodine (RAI) therapy. Oncoproteins that constitutively activate MAPK signaling suppress expression of genes...
T Cell Responses to Neoantigens in Fibrolamellar Carcinoma
PROJECT SUMMARY Fibrolamellar carcinoma (FLC) is a rare liver tumor with poor outcomes: 5-year overall survival is reported at only 35-45%, and relapse rates are reported at 57-100...
T cell expressed miR-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the second deadliest cancerglobally and has the third-highest incidenceand mortality rate of all cancers in the United States. P...
Mitochondrial heterogeneity as the origin of chemoresistance in pancreatic cancer
Summary Therapeutic resistance and tumor relapse present as major barriers to achieving a definitive cure for cancer. This challenge is especially relevant for patients with pancre...
Ferroptosis as a Modulator of Checkpoint Inhibitor Immunotherapy
Melanoma is the deadliest form of skin cancer and expected to cause 8000 deaths in the United States in 2019. Although treatment with anti-CTLA-4 and anti-PD-1 immune checkpoint in...
Understanding Telomere Elongation Mechanisms in Cancer
Project Summary Malignant cancers must activate telomere maintenance mechanisms to achieve replicative immortality. Mutations in the human Protection Of Telomeres 1 (hPOT1) protein...
Molecular Pathogenesis and Therapy of Systemic Histiocytic Neoplasms
Project Summary Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage that include Langerhans Cell Histiocytosis (LCH), Erdheim-Chester Disease (ECD), Juven...
Oligo(lactic acid)n-Prodrug Nanomedicines for Combination Therapy
Project Summary/Abstract Taxol is commonly used to treat TNBC and increasingly in combination with oral signal transduction inhibitors (STIs), such as mTOR inhibitor (Afinitor) a...
Geranylgeranyl diphosphate synthase inhibitor therapy for multiple myeloma
Project Summary Multiple myeloma (MM) is an incurable bone marrow (BM) cancer characterized by the production of monoclonal protein (MP). Development of drug resistance and off-tar...
Mechanisms of tumor microenvironmental regulation of T-cell infiltration in melanoma
Project Summary Melanoma is the deadliest form of skin cancer, with over 100,000 new cases and 6,000 deaths predicted in the United States in 2020. While the advent of immune check...
Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults
Project Summary Although smoking prevalence has declined to 13.7% among U.S. adults, smoking rates are much higher among socioeconomically disadvantaged adults. Lung cancer, which...