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20,252 grants found
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Elucidating pro-metastatic collagen modifying activities of lysyl hydroxylase 2
As they progress, malignant tumors accumulate cross-linked collagen fibrils that enhance matrix stiffness, thereby activating collagen receptors that trigger cancer cell invasion a...
Genetic Predisposition to Chronic Lymphocytic Leukemia (CLL)
Project Summary CLL is the most common leukemia of adults in North America, with about 20,000 new cases per year, and remains incurable. Although a small subset of patients has ind...
Predicting sensitivity and resistance in RET-driven cancers
Selpercatinib (LOXO-292) is a highly active selective RET inhibitor explored on an ongoing registrational program (LIBRETTO-001 phase 1/2 trial) in RET-dependent cancers (US FDA ap...
The Pediatric Advanced Cancer Experience (PACE): Measuring Quality of End-of-Life Care for Children with Cancer
PROJECT SUMMARY Although cure rates for childhood cancer have increased over several decades, cancer remains the leading cause of non-accidental death in children. Yet, there are n...
Accurate DCE-MRI Measurement of Glioblastoma using Point-of-care Portable Perfusion Phantom
PROJECT SUMMARY / ABSTRACT The goal of this R03 study is to conduct a pilot study testing whether the variability in quantitative DCE- MRI measurement of glioblastoma across differ...
Profilin biology in breast cancer
Breast cancer the most frequently diagnosed non-skin cancer in women, ranks second among cancer deaths in women in the United States. The vast majority of these deaths are due to m...
Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
Hematologic cancer patients are at high risk for developing insomnia and daytime fatigue, pain, and distress in the months after inpatient treatment. Extended hospitalization for c...
Epigenetic regulators of subtype plasticity in bladder cancer
Project Summary/Abstract Bladder cancer can be subdivided into two categories: non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). NMIBC is treate...
Longitudinal Proteomic and Metabolomic Predictors of Pancreatic Cyst Malignant Progression and Early Stage Pancreatic Cancer
Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDAC) has a dire prognosis mainly due to its late diagnosis. It is vital to identify early-stage PDAC and its precursors....
Investigating the roles of extracellular cGAMP and harnessing it for cancer treatment
PROJECT SUMMARY The goal of cancer immunotherapy is to awaken the body’s anti-tumoral immune response to fight against all cancers in all patients. Our lab recently identified a ke...
Investigating the metabolic regulation of tumor desmoplasia
PROJECT SUMMARY/ABSTRACT The ability of fibroblasts to synthesize extracellular matrix (ECM) proteins is critical for wound healing; however, this program is coopted by cancer cell...
Lymph node regulation of metastatic fitness and reemergence
PROJECT SUMMARY Metastasis is the most dangerous stage of cancer, responsible for the vast majority of breast cancer-related deaths. Currently, we have no treatments that target me...
T cell expressed miR-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the second deadliest cancerglobally and has the third-highest incidenceand mortality rate of all cancers in the United States. P...
A novel determinant of prostate cancer growth
Project Summary/Abstract Prostate cancer (CaP) will cause the deaths of more than 33,000 American men in 2020 because systemic treatments for metastatic CaP fail. Actionable target...
Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer
Project Summary Despite the advent of aggressive cervical cancer screening programs, cervical cancer remains one of the most common cancers affecting women under age 35, and the fo...
Team-based Interdisciplinary Cancer Research Training Program
TEAM-BASED INTERDISCIPLINARY CANCER RESEARCH TRAINING PROGRAM PROJECT SUMMARY/ABSTRACT In advancing innovative ways to address complex cancer challenges, there is a growing trend t...
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy
PROJECT SUMMARY: Pancreatic ductal adenocarcinoma (PDA) will become the 2nd leading cause of cancer deaths in the United States by 2030. Most patients with PDA present with nonrese...
Imaging and manipulating oncoprotein phase separation and compartmentalization
Abstract MYC oncoproteins including c-Myc and MYCN are major drivers of human tumorigenesis. Expression of MYC is deregulated and enhanced in many types of human cancer. For instan...
Mechanistic maps of adaptive responses to therapeutic stress to optimize combination therapies.
Summary. In triple-negative breast cancer and high-grade serous ovarian cancer, the emergence of resistance to therapy is virtually inevitable and contributes to dismal long-term p...
Understanding and targeting MAPK pathway activation in NF1-deficient malignant peripheral nerve sheath tumor (MPNST)
Project Abstract Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive soft tissue sarcomas that occur in distinct clinical settings: neurofibrom...