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20,252 grants found
Showing 18,481 – 18,500 of 20,252 grants
Oligo(lactic acid)n-Prodrug Nanomedicines for Combination Therapy
Project Summary/Abstract Taxol is commonly used to treat TNBC and increasingly in combination with oral signal transduction inhibitors (STIs), such as mTOR inhibitor (Afinitor) a...
Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial
PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is n...
Function of mesothelial cells in the tumor microenvironment of pancreatic ductal adenocarcinoma
Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal disease characterized by extensive desmoplasia caused by the rapid expansion of cancer-associated fibrob...
Targeting Epigenomic Regulators at the Replication Fork in PDAC
Pancreatic adenocarcinoma (PDAC) remains a therapeutic challenge, making the identification of new targets and development of novel treatment strategies for this disease of paramou...
Mutational cooperativity in TET2-associated hematological malignancies.
Project Summary/ Abstract Peripheral T cell lymphoma (PTCL) represents a group of aggressive blood cancers derived from mature T cells, and remains as a high unmet clinical need wi...
Gene Expression Analysis of Dog Natural Killer Cells as Immunotherapy Target
Project Summary Dogs are large, outbred animals that develop cancer spontaneously in the presence of an intact immune system and in the setting of shared environmental exposures wi...
Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias
PROJECT SUMMARY The mixed-lineage leukemia (MLL) gene rearrangements account for approximately 80% of infant acute lymphoblastic leukemia (ALL) and 35-50% of infant acute myeloid l...
Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapy
Abstract: Immunotherapy using programmed death 1 receptor (PD-1) blockade, either alone or in combination with existing therapies, has been proven to significantly improve survival...
Genetic Determinants of Evolutionary Trajectories and Clinical Course in Pancreatic Cancer
PROJECT SUMMARY Genetic intratumoral heterogeneity (gITH) has been associated with cancer progression and is thought to be a major contributor to treatment resistance. However, the...
Ferroptosis as a Modulator of Checkpoint Inhibitor Immunotherapy
Melanoma is the deadliest form of skin cancer and expected to cause 8000 deaths in the United States in 2019. Although treatment with anti-CTLA-4 and anti-PD-1 immune checkpoint in...
Targeting the Oncogenic Fusion Transcription Factor PAX3-FOXO1 with Small Molecules
PROJECT SUMMARY Fusion transcription factors (TFs) are an enticing class of cancer targets. When present in a malignancy, these chimeric proteins are often the primary oncogenic dr...
Mechanism of Transformation in T-Cell Lymphomas: Identification of Therapeutic Targets
Project Summary T-cell lymphomas (TCL) are a highly aggressive and heterogeneous group of non-Hodgkin lymphomas derived from post-thymic mature T- and NK-cells. Limited understandi...
FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma
PROJECT SUMMARY Ewing Sarcoma Family of Tumors (ESFT) are bone and soft tissue cancers that affect children and adolescents. Surgery, radiation and multi-agent chemotherapy have im...
Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes
Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ≥65-years, ≥1-year post- treatment) have clinically significant depression. Presently, 64% of cancer...
Defining the role of FAM83B in lung cancer using a new mouse model
ABSTRACT RAS signaling is one of the most commonly altered oncogenic pathways in human cancer and one of the most targeted pathways in drug discovery programs. Yet, while numerous...
Targeting allosteric scaffolding functions of Aurora kinase A in cancer
ABSTRACT Neuroblastoma is the most common solid tumor in infants. About 25% of patients have high-risk neuroblastoma, a devastating disease with poor prognosis and few treatment op...
Leveraging deep learning for markerless motion management in radiation therapy
Leveraging deep learning for markerless motion management in radiation therapy Project Summary Organ motion is a predominant limiting factor for the maximum exploitation of modern...
Understanding Efficacy and Fe(II)-Promoted Activation of 1,2,4-Trioxolanes in Cancer
Project Summary/Abstract Summary: Precision cancer medicine’s foundation lies in discovering and exploiting pathways that are essential for cancer cells, but dispensable for cancer...
The Adenosinergic Pathway in Tumor-derived Exosomes
PROJECT SUMMARY/ABSTRACT Tumor cells produce and release large numbers of extracellular vesicles (EVs). A subset of small (30-150 nm) EVs derived from the endocytic compartment of...
Eliminating B Cell Precursor Acute Lymphoblastic Leukemia by Targeting the Uniquely Specific Pre-B Cell Receptor
ABSTRACT B cell precursor acute lymphoblastic leukemia (BCP-ALL), a malignancy that arises from mutant pre-B cells, is the most common childhood leukemia but also occurs in adults....