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20,252 grants found
Showing 18,461 – 18,480 of 20,252 grants
Innovative Droplet Lenses for NextGen Light Sensors of Biomarkers of Inflammation
Project Summary/Abstract While the efficacy of immunotherapy can be staggering, a major side effect is that there can be an ensuing excessively robust immune response, which can le...
Network mechanisms and bioengineering of precision immunotherapies for glioblastomas
Project Summary/Abstract Glioblastoma multiforme (GBM) is the most common and lethal malignancy of the human central nervous system (CNS). This devastating disease has a median ove...
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
PROJECT SUMMARY Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanisms, res...
FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma
PROJECT SUMMARY Ewing Sarcoma Family of Tumors (ESFT) are bone and soft tissue cancers that affect children and adolescents. Surgery, radiation and multi-agent chemotherapy have im...
A Multi-pronged Computational Approach to Advance Kinase Drug Discovery
Project Summary/Abstract In recent years, computing speed has exponentially increased; however, the potential of computational ap- proaches to accelerate drug discovery has not bee...
Regulation of DGAT - dependent lipogenesis in colonic epithelial growth
Abstract Obesity is characterized by systemic lipid accumulation, inflammation, and enhanced tumorigenesis in different tissues, including colon. With obesity, intracellular lipid...
Elucidating Human Leukemia and T Cell Interactions within the Tumor Microenvironment
Project Summary/Abstract Leukemic relapse remains the major obstacle to successful allogeneic stem cell transplantation (allo-SCT). Here, donor lymphocyte infusion (DLI) seeks to r...
The selective advantage of mismatch repair loss in colonic stem cells
Project Summary Lynch syndrome (LS) is a hereditary disease that predisposes patients to colorectal, endometrial, ovarian and other cancers. LS is caused by inherited mutations in...
Longitudinal Proteomic and Metabolomic Predictors of Pancreatic Cyst Malignant Progression and Early Stage Pancreatic Cancer
Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDAC) has a dire prognosis mainly due to its late diagnosis. It is vital to identify early-stage PDAC and its precursors....
Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial
PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is n...
Elucidating pro-metastatic collagen modifying activities of lysyl hydroxylase 2
As they progress, malignant tumors accumulate cross-linked collagen fibrils that enhance matrix stiffness, thereby activating collagen receptors that trigger cancer cell invasion a...
Mathematical Model-Guided Adoptive Immunotherapy in Bladder Cancer
Summary Bladder cancer is the fourth most common cancer in men and a leading cause of cancer mortality among men and women with the rates of bladder cancer incidents and bladder ca...
Efficacy of a Mindfulness-Based Stress Management Program for Allogeneic HCT Caregivers
PROJECT SUMMARY/ABSTRACT Caring for an allogeneic hematopoietic stem cell transplant (HCT) patient is a significant responsibility, involving a commitment to be available 24/7 up t...
Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias
PROJECT SUMMARY The mixed-lineage leukemia (MLL) gene rearrangements account for approximately 80% of infant acute lymphoblastic leukemia (ALL) and 35-50% of infant acute myeloid l...
Robot-Assisted Personalized Prostate Biopsy
PROJECT SUMMARY/ABSTRACT Prostate cancer (PCa) is the most commonly diagnosed type of cancer and the second leading cause of cancer related death among US men. The best current est...
Leveraging deep learning for markerless motion management in radiation therapy
Leveraging deep learning for markerless motion management in radiation therapy Project Summary Organ motion is a predominant limiting factor for the maximum exploitation of modern...
Deconstructing and targeting aneuploidy in human cancer - Resubmission - 1
Summary Aneuploidy—the presence of chromosome gains and losses—is very rare in normal tissues but occurs in more than 80% of human tumors, especially in solid tumors. A high level...
Mathematical Model-Guided Adoptive Immunotherapy in Bladder Cancer
Summary Bladder cancer is the fourth most common cancer in men and a leading cause of cancer mortality among men and women with the rates of bladder cancer incidents and bladder ca...
Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1
PROJECT SUMMARY While the technological enterprise of magnetic resonance imaging (MRI) generates a host of biomarkers of the tumor environment, in particular for breast cancer, pre...
Does obesity influence protein quality control in endometrial cancer?
PROJECT SUMMARY/ABSTRACT Research Project: Excess body weight is a contributing factor in up to 20% of all cancer deaths in women. In particular, endometrial cancer (EC) incidence...