Browse All Grants
20,252 grants found
Showing 18,441 – 18,460 of 20,252 grants
Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome
ABSTRACT While the outcomes for children with acute lymphoblastic leukemia (ALL) have improved dramatically over the past four decades, major challenges remain including the burden...
Molecular mechanism of EGFRs protein-protein interaction inhibition by a grafted peptide in NSCLC
Project Summary: The long-term objective of this research project is to understand the role of dimerization in extracellular domains (ECD) of epidermal growth factor receptors (EGF...
Elucidating the impact of DNA hypomethylation on genome organization and anti-tumor transcriptional programs
PROJECT SUMMARY This proposed research career development program seeks to investigate the impact of DNA hypomethylation on genome organization and the mechanisms by which it drive...
Advanced diffusion MRI for evaluating early response to radiation treatment in cervical cancer
Project Summary Despite the advent of aggressive cervical cancer screening programs, cervical cancer remains one of the most common cancers affecting women under age 35, and the fo...
Post-doctoral Training Program in Cancer Metabolism and Tumor-host Interactions
Rutgers Cancer Institute of New Jersey (RCINJ) provides an outstanding environment for training in basic, clinical, behavioral or population-based cancer research and brings togeth...
Investigating the roles of extracellular cGAMP and harnessing it for cancer treatment
PROJECT SUMMARY The goal of cancer immunotherapy is to awaken the body’s anti-tumoral immune response to fight against all cancers in all patients. Our lab recently identified a ke...
Optimizing Therapeutic STING Agonism in Triple Negative Breast Cancer
PROJECT SUMMARY Despite the therapeutic promise of STING agonists in cancer, first in human studies have been hampered by lack of precision therapy and issues with drug delivery. M...
Automated Assessment for Robotic Suturing Utilizing Deep Learning Algorithms
ABSTRACT Medical errors are the third leading cause of death in the US at a cost of $20 billion annually. Surgical complications account for a third of these deaths and cost. Surgi...
Eco-evolutionary drivers of clonal dynamics during UV-induced skin carcinogenesis (PQ3)
ABSTRACT Cancers have readily-defined characteristics often referred to as “hallmarks”. Nevertheless, the question of how the sequence of cancer development progresses -- from norm...
Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
Hematologic cancer patients are at high risk for developing insomnia and daytime fatigue, pain, and distress in the months after inpatient treatment. Extended hospitalization for c...
Targeting Lymph Node Dependent Immune Tolerance in Cancer
Project Summary Background: Malignant melanoma and pancreatic ductal adenocarcinoma (PDAC) typically spread to lymph nodes (LNs) prior to outgrowth in distant tissues. While metast...
Genetically faithful modeling of NUP98 rearrangement and co-alterations in acute myeloid leukemia
PROJECT SUMMARY Chromosomal translocations involving Nucleoporin 98 (NUP98) are observed in approximately 5% of pediatric acute myeloid leukemia (AML) and are associated with resis...
Profilin biology in breast cancer
Breast cancer the most frequently diagnosed non-skin cancer in women, ranks second among cancer deaths in women in the United States. The vast majority of these deaths are due to m...
The Adenosinergic Pathway in Tumor-derived Exosomes
PROJECT SUMMARY/ABSTRACT Tumor cells produce and release large numbers of extracellular vesicles (EVs). A subset of small (30-150 nm) EVs derived from the endocytic compartment of...
Credentialing Models of Invasive Lobular Breast Cancer for Translational Research
Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after the more common invasive ductal breast cancer (IDC). In 2020, ILC will af...
Relaxed Polymerase Pausing as a Driver of Epigenetic Plasticity and Cancer Cell Invasion
Project Summary The development of distant metastases accounts for a significant proportion of breast cancer mortality; as many as 30% of patients initially diagnosed at an early s...
Mutational cooperativity in TET2-associated hematological malignancies.
Project Summary/ Abstract Peripheral T cell lymphoma (PTCL) represents a group of aggressive blood cancers derived from mature T cells, and remains as a high unmet clinical need wi...
Minibeam Radiation Therapy Enhanced Delivery of Nanoparticle Anticancer Agents to Pancreatic Cancer Tumors
PROJECT SUMMARY / ABSTRACT: Nanoparticles (NPs) hold great promise for delivering more effective and safer cancer treatment than the small molecule drugs that are commonly used. Th...
PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
Project Summary: Illness behaviors, metabolic disturbances, and cognitive decline are common in patients with chronic systemic diseases, and contribute substantially to quality of...
Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapy
Abstract: Immunotherapy using programmed death 1 receptor (PD-1) blockade, either alone or in combination with existing therapies, has been proven to significantly improve survival...