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20,252 grants found
Showing 18,421 – 18,440 of 20,252 grants
Relaxed Polymerase Pausing as a Driver of Epigenetic Plasticity and Cancer Cell Invasion
Project Summary The development of distant metastases accounts for a significant proportion of breast cancer mortality; as many as 30% of patients initially diagnosed at an early s...
Metabolic Regulation of the Epigenetic Landscape in T cell Exhaustion
ABSTRACT/PROJECT SUMMARY My overarching goal is to understand the regulation of the metabolism-epigenetic axis in cancer and cancer associated pathologies. T cell exhaustion (Tex)...
Mechanisms of cysteinyl leukotriene receptor 2 (CysLT2R)-mediated signaling and migration in melanocytes and uveal melanoma
PROJECT SUMMARY (ABSTRACT) Melanocytes comprise a heterogeneous group of neural crest-derived cells that are present in the skin, eyes, ear, heart, and brain. While the function of...
Methods for improved detection of activated molecular pathways in cancer
PROJECT SUMMARY/ABSTRACT Studying tumors by quantifying gene expression via RNA-sequencing (RNA-seq) has proven crucial to elucidating their active biological pathways and processe...
The role of HOXD13 in controlling Ewing sarcoma cell plasticity and metastasis
Project Summary Ewing sarcoma is an aggressive bone tumor that has a peak incidence in children and adolescents. Systemic chemotherapy and local control measures have improved surv...
Examining Mitochondria Dysfunction and Oxidative Stress in Senescence
PROJECT SUMMARY/ABSTRACT Cancer metastasis is responsible for 90% of cancer-related mortality world-wide.[1] A widely-held hypothesis is that during cancer progression, heterogeneo...
T Cell Responses to Neoantigens in Fibrolamellar Carcinoma
PROJECT SUMMARY Fibrolamellar carcinoma (FLC) is a rare liver tumor with poor outcomes: 5-year overall survival is reported at only 35-45%, and relapse rates are reported at 57-100...
Regulation and recognition of H3K79me
Project Summary/Abstract Patterns of dynamic post-translational modifications on histone proteins of nucleosomes regulate local and global eukaryotic gene expression by recruiting...
Define the Role of POT1 Mutation in Genome Instability and Cancer
Project Summary The goal of this proposal is to investigate the mechanism by which alteration in the telomere binding protein POT1 results in tumorigenesis. Mutations in POT1 (>...
Optimizing Dual-Targeted and Dual-Armored CAR T Cells for Small Cell LungCancer
ABSTRACT A patient's own T cells can be modified using gene therapy technology to express receptors, termed chimeric antigen receptors or CARs, which allow these immune T cell...
Developing and Testing a Digital Toolkit to Improve Colorectal Cancer Screening Rates in Federally Qualified Health Centers
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer death in the United States. National guidelines recommend that average risk people receive regular CRC...
Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem
Project Summary/Abstract Diversity Supplement Title: Identification of Plasma Microbiota Biosignatures for Early Epithelial Ovarian Cancer Detection Annually over 21,000 women are...
Expanding the scope of protein degradation and stability using chemoproteomic platforms
Targeted protein degradation (TPD) has arisen as a powerful drug discovery platform for tackling the undruggable proteome by targeting specific proteins for proteasomal degradation...
Developing newly combined therapeutic strategies for mature B cell lymphoma
While PD-1 blockade is effective in relapsed or refractory classical Hodgkin lymphoma (cHL) and in a subset of diffuse large B cell lymphomas (DLBCL) patients, a majority of B cell...
Analyzing the Hypersensitivity of MMR-deficient Colorectal Cancers to mTOR Inhibition and the Response of Cancer Stem Cells
Project Summary Mutations in DNA mismatch repair (MMR) genes are causative in Lynch Syndrome (LS) and defective MMR drives tumorigenesis in a significant proportion (15 - 20%) of s...
Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults
Project Summary Although smoking prevalence has declined to 13.7% among U.S. adults, smoking rates are much higher among socioeconomically disadvantaged adults. Lung cancer, which...
Effectiveness and implementation of a health system intervention to improve quality of cancer care for rural, underserved patients
PROJECT SUMMARY There is growing evidence that limited access to high-quality cancer treatment is one of the main drivers of higher cancer mortality rates among rural cancer patien...
Innovative Droplet Lenses for NextGen Light Sensors of Biomarkers of Inflammation
Project Summary/Abstract While the efficacy of immunotherapy can be staggering, a major side effect is that there can be an ensuing excessively robust immune response, which can le...
HER2-mediated delivery of cytotoxic agents in solid tumors
PROJECT SUMMARY ERBB2/HER2 is a receptor tyrosine kinase (RTK) that is amplified/overexpressed in 15-20% of breast and gastroesophageal cancers, for which anti-HER2 therapy is now...
Targeting replication stress signaling to overcome immune evasion in small cell lung cancer
New therapeutic strategies are urgently needed to improve immune checkpoint blockade (ICB) therapy in small cell lung cancer (SCLC). SCLCs rely heavily on the replication stress re...