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20,252 grants found
Showing 18,401 – 18,420 of 20,252 grants
Human papillomavirus in HIV associated lung cancers
SUMMARY In recent years, the incidence of AIDS-defining cancers has dramatically decreased due to the HAART therapy.In contrast, the incidence of the non-AIDS-defining cancers (NAD...
A System for Xerostomia Risk Classification after Head & Neck Cancer Radiotherapy
Summary Radiotherapy (RT) is a major component in the treatment of most head and neck cancer (HNC) cases.During irradiation, sensitive regions such as the salivary glands can susta...
Digital Melt Curve Analysis Platform for Longitudinal Cancer Patient Monitoring
Abstract Building on its commercially available Absolute Q digital PCR platform, during the 24-month Phase 2 SBIR project, Combinati will complete the development of the first Digi...
Enabling remote medical physics services for medical accelerator quality assurance through a novel, table-top imaging device
Project Summary / Abstract Radiation therapy is an effective component of the treatment strategy for patients suffering from smoking- related cancers.Advanced techniques such as in...
Smoking Cessation in Persons with Mental Health Conditions: Exploring the Role of Family and Friends
PA-20-251 Ruth L.Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity). Smoker...
Understanding Efficacy and Fe(II)-Promoted Activation of 1,2,4-Trioxolanes in Cancer
Project Summary/Abstract Summary: Precision cancer medicine?s foundation lies in discovering and exploiting pathways that are essential for cancer cells, but dispensable for cancer...
The role of CaMKK2 in tumor-infiltrating natural killer cells
Abstract: Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is an important regulator of cellular metabolism.Though classically associated with neurons and macrophages,...
Lipid metabolism as a therapeutic vulnerability in BET inhibitor-resistant medulloblastoma
Project Summary/Abstract MYC-driven medulloblastomas are a particularly devastating group of pediatric brain tumors that exhibit resistance and continued progression despite standa...
A Novel Microbiome-Based Immune-Modulator that Potentiates Cancer Checkpoint Therapy
Project Summary The goal of this project is to develop a novel oral drug, R-5780, which engages microbiome-associated Pattern Recognition Receptors (PRRs) to enhance the activity o...
Correcting [18]F-Misonidazole PET with MRI and EPR to improve hypoxia-guided radiation therapy
Project Summary In this project, we propose to correct [18]F-Misonidazole (FMISO) Positron Emission Tomography (PET) images to make PET be more accurate in measuring hypoxia.Hypoxi...
Degradation of the Nucleosome Remodeling Complex, NURF, with Bromodomain-Targeting Heterobifunctional Molecules
PROJECT SUMMARY Deregulation of the epigenetic reader protein Bromodomain and PHD finger-containing transcription factor (BPTF) has recently been shown to play a role in various ca...
Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapy
Abstract: Immunotherapy using programmed death 1 receptor (PD-1) blockade, either alone or in combination with existing therapies, has been proven to significantly improve survival...
Viscotaxis: Novel cell migration mechanisms regulated by microenvironmental viscosity
Cell motility is a key step in the metastatic cascade of events, as it enables cancerous cells dissociating from a primary tumor to navigate through interstitial tissues and ultima...
Defining the regulation of UHRF1 and DNMT1 for maintenance of the epigenome
PROJECT SUMMARY In multicellular organisms, methylation of DNA on the 5? carbon of cytosine helps ensure proper gene expression.Methylation occurs symmetrically on both DNA strands...
T cell expressed miR-155 promotes antitumor immunity and immune checkpoint blockade responses in colon cancer through repression of Ship1
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is the second deadliest cancerglobally and has the third-highest incidenceand mortality rate of all cancers in the United States.Pa...
Regulation and recognition of H3K79me
Project Summary/Abstract Patterns of dynamic post-translational modifications on histone proteins of nucleosomes regulate local and global eukaryotic gene expression by recruiting...
Immune Biomarker Assessment and Manufacturing Development for SQ3370-001, a first-in-human phase I dose-escalation clinical trial to test a novel treatment against advanced solid tumors
Abstract In 2018, the global incidence of new cancer diagnoses was estimated at over 18 million cases, and cancer- related deaths were estimated at over 9.6 million.Of these cases,...
Epigenetic regulators of subtype plasticity in bladder cancer
Project Summary/Abstract Bladder cancer can be subdivided into two categories: non-muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC).NMIBC is treated...
Leveraging deep learning for markerless motion management in radiation therapy
Leveraging deep learning for markerless motion management in radiation therapy Project Summary Organ motion is a predominant limiting factor for the maximum exploitation of modern...
T Cell Responses to Neoantigens in Fibrolamellar Carcinoma
PROJECT SUMMARY Fibrolamellar carcinoma (FLC) is a rare liver tumor with poor outcomes: 5-year overall survival is reported at only 35-45%, and relapse rates are reported at 57-100...