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20,252 grants found
Showing 18,381 – 18,400 of 20,252 grants
Defining the role of FAM83B in lung cancer using a new mouse model
ABSTRACT RAS signaling is one of the most commonly altered oncogenic pathways in human cancer and one of the most targeted pathways in drug discovery programs.Yet, while numerous s...
A Simulation Modeling Study to Support Personalized Breast Cancer Prevention and Early Detection in High-Risk Women
Abstract: Personalized care is complex in this unprecedented era of discovery and ?big data?.The proposed study focuses on the real-world choices facing over 100,000 US women each...
A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep
Project Summary Over 50% of pediatric cancer patients report problems with their sleep, characterized by insomnia disorder symptoms.This results in considerable physical and psycho...
Gene Expression Analysis of Dog Natural Killer Cells as Immunotherapy Target
Project Summary Dogs are large, outbred animals that develop cancer spontaneously in the presence of an intact immune system and in the setting of shared environmental exposures wi...
Robot-Assisted Personalized Prostate Biopsy
PROJECT SUMMARY/ABSTRACT Prostate cancer (PCa) is the most commonly diagnosed type of cancer and the second leading cause of cancer related death among US men. The best current est...
Understanding the Guideline-Discordant Use of Bone Modifying Agents in Prostate Cancer
PROJECT SUMMARY Bone-modifying agents (BMAs) can improve quality-of-life in metastatic prostate cancer.The BMAs zoledronic acid and denosumab prevent bone fractures among men with...
Roles of Coactivator-Associated Arginine Methyltransferase 1 in B cell activation and lymphomagenesis
PROJECT SUMMARY Follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL) are the most common germinal center (GC)- derived Non-Hodgkin B cell lymphomas (BCLs).Although in...
Harnessing Rare Variants for Tumor Classification
Abstract This project concerns how to extract clinically actionable information for diagnostic purposes from mutational patterns observed from tumor sequencing panels that are incr...
Analyzing the Hypersensitivity of MMR-deficient Colorectal Cancers to mTOR Inhibition and the Response of Cancer Stem Cells
Project Summary Mutations in DNA mismatch repair (MMR) genes are causative in Lynch Syndrome (LS) and defective MMR drives tumorigenesis in a significant proportion (15 - 20%) of s...
Mechanisms of tumor microenvironmental regulation of T-cell infiltration in melanoma
Project Summary Melanoma is the deadliest form of skin cancer, with over 100,000 new cases and 6,000 deaths predicted in the United States in 2020.While the advent of immune checkp...
Targeting the IL-33/ST2 Pathway in Colorectal Cancer Immunotherapy
Summary/Abstract: I am a postdoctoral fellow at Indiana University who has developed a unique set of skills in tumor immunology and cancer immunotherapy.Throughout my graduate and...
Behavioral Activation for Depression in Older Adult Cancer Survivors: Pilot Randomized Control Trial and Implementation Outcomes
Project Summary/Abstract: As many as 35% of older adult cancer survivors (OACS; ?65-years, ?1-year post- treatment) have clinically significant depression. Presently, 64% of cancer...
Investigating Transcriptional Elongation and Nuclear RNA Surveillance in Melanoma
Project Summary Metastatic melanoma, a cancer derived from pigment-producing melanocytes, is the deadliest type of skin cancer. Metastatic melanoma that is refractory or resistant...
Mindfulness and Cognitive Behavioral Therapy for Sleep in Cancer
Hematologic cancer patients are at high risk for developing insomnia and daytime fatigue, pain, and distress in the months after inpatient treatment.Extended hospitalization for ch...
Function of mesothelial cells in the tumor microenvironment of pancreatic ductal adenocarcinoma
Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal disease characterized by extensive desmoplasia caused by the rapid expansion of cancer-associated fibrob...
Can a subset of patients with HER2+ metastatic breast cancer be cured?
PROJECT SUMMARY Because of the development of highly effective HER2-targeted therapies over the past two decades, most patients now diagnosed with stage I-III HER2+ breast cancer (...
TRANSCRIPTIONAL REPROGRAMMING OF ESR1 MUTANT BREAST CANCER IN METASTASIS AND TREATMENT RESISTANCE
Project Summary Up to 1 in 8 women in the United States will develop invasive breast cancer in their lifetime, with 70-80% of cases being estrogen receptor positive (ER+).These can...
Targeting the Oncogenic Fusion Transcription Factor PAX3-FOXO1 with Small Molecules
PROJECT SUMMARY Fusion transcription factors (TFs) are an enticing class of cancer targets.When present in a malignancy, these chimeric proteins are often the primary oncogenic dri...
Federal School Nutrition Policies, Student Food Insecurity and BMI
Project Abstract Food insecurity increased since COVID-19 and children who are food insecure are at increased risk of physical and mental health disorders.In response to pandemic-r...
Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution
ABSTRACT: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi?s) have emerged as important new therapeutic agents targeting a broadening class of gene mutations present in breast...