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20,252 grants found
Showing 1,821 – 1,840 of 20,252 grants
Resubmission- Deep Neural Networks to Identify Moments of Human Connection in Cancer Communication
PROJECT SUMMARY/ABSTRACT Promoting high quality communication in serious illness is a pressing national priority. However, traditional approaches to measuring communication in the...
Impact of the senescent bone marrow microenvironment in AML biology
Project Summary Acute myeloid leukemia (AML) is the most common diagnosed adult leukemia, the median age of patients with AML is about 70-years. Although the prognosis for younger...
Rational Vaccine Design to prevent HIV-Associated Lymphoma
PROJECT SUMMARY/ABSTRACT Relative to the general population, HIV-infected individuals have a 60–200-fold higher relative risk to develop Non-Hodgkin's Lymphomas, including pla...
Development of SUV39H1-selective inhibitor for human colon cancer therapy
Project Summary Only the microsatellite instability high (MSI-H) human colorectal cancer, which accounts for 10-15% of all human colorectal cancer cases, responds to PD-(L)1 blocka...
Elucidating Mechanisms of CAR ML NK cell biology to treat cancer and infection
PROJECT SUMMARY Candidate: During my training, I have been highly motivated to understand how cytotoxic lymphocytes can be used as an adoptive therapy and how immune cells are regu...
THE T-CELL RECEPTOR'S ROLE IN T-CELL LYMPHOMA PATHOGENESIS
The majority of patients afflicted with a T-cell lymphoma (TCL) will experience disease progression and ultimately succumb to their disease, as current therapies are rarely curativ...
Targeting immunosuppression of intratumoral CAR T cells
ABSTRACT The clinical benefits of cancer immunotherapies, including adoptive cell transfer (ACT) of chimeric antigen receptor (CAR) T cells, are limited when used against solid tum...
MRI and blood biomarkers of neoadjuvant therapy response and outcomes in rectal cancer
ABSTRACT Rectal cancer is a common cancer and leading cause of cancer death. The majority of rectal cancer patients are diagnosed with stage II or III locally advanced disease. Neo...
The role of the mycobiome in cancer
Abstract Cancer is among the leading causes of death worldwide and host-bacterial microbiota interactions profoundly influence tumorigenesis, cancer progression and response to the...
Developing clinically relevant PET tracers to image T cell activation for improved cancer immunotherapy monitoring
SUMMARY Chimeric antigen receptor (CAR) T cell therapies represent a major advancement in the cancer immunotherapy (IOT) field and have shown remarkable success particularly for tr...
Augmenting PSMA expression to enhance PSMA directed therapeutic efficacy
PROJECT SUMMARY/ABSTRACT Despite treatment advances over the past decade, metastatic prostate cancer (PC) remains a fatal disease. As such, there is an acute need for additional tr...
Lectikines for Immunotherapy against Ovarian Cancer
SUMMARY The goal of this project is to create a novel immunotherapeutic drug candidate against ovarian cancer (OVCA). OVCA is the leading cause of death from gynecological malignan...
Dual inhibition of PARP and STAT3 as a novel therapeutic approach for triple-negative breast cancer
Project Summary Triple-negative breast cancer (TNBC) is highly aggressive and is associated with poor clinical outcomes. TNBC is a major cause of death among breast cancer patients...
Characterization and treatment of a novel model of radiation optic neuropathy using the tree shrew
PROJECT SUMMARY/ABSTRACT Uveal melanoma (UM) is the most common primary intraocular tumor of adulthood, and radiation-based therapies are the mainstay treatment for most small, med...
In vivo testing of an agonistic anti-GITR mAb that induces cell surface clustering to augment signal transduction and a 2nd Gen bispecific anti-GITR/PD1 Ab derivative for improved anti-tumor activity
Project Summary The durability of clinical responses to immune checkpoint inhibitors targeting PD1 has generated tremendous interest in immunotherapy of cancers. However, not all p...
The role of AHR in modulatingimmunotherapy response and adverse events in bladder cancer
PROJECT SUMMARY One hallmark of cancer is a tumor’s ability to evade immune detection and elimination. Immune checkpoint inhibitors (ICIs) are an attractive therapeutic strategy fo...
Detecting Reversal of Apoptosis in Cancer Cells in Mice
Detecting Reversal of Apoptosis in Cancer Cells in Mice Project Summary Targeting apoptotic pathways is one of the most important therapeutic strategies for cancer treatments, and...
Dissecting spatiotemporal heterogeneity of glioblastoma evolution under therapy
PROJECT SUMMARY: Glioblastoma (GBM) is an uncurable form of primary brain tumor with extremely poor prognosis. Despite multi- modal therapy including surgery, irradiation and chemo...
L-fucose-mediated enrichment of memory CD4+T cells and enhanced anti-melanoma immunity
The efficacy of current cancer immunotherapies is limited in terms of upfront responsiveness in subsets of treated patients and durability of responses. Significant efforts are bei...
Improving safety and access to immune effector cell therapy with artificial intelligence technology
PROJECT SUMMARY Immune effector cell-associated neurotoxicity syndrome (ICANS) is a cluster of symptoms associated with immunotherapy that did not show up in pre-clinical studies b...