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20,252 grants found
Showing 18,361 – 18,380 of 20,252 grants
Identifying multi-level barriers and facilitators to digital health use in federally qualified health centers
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer death in the United States. National guidelines recommend that average risk people receive regular CRC...
Dissecting Single-cell Response or Resistance to Novel Combination Therapy in AML using Mass Cytometry
PROJECT SUMMARY This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-21-034. Acute myeloid leukemia (AML) is among the dead...
Contribution of ERa/PR Crosstalk to Endocrine Therapy Resistance in the Context of ERa-Y537S
PROJECT SUMMARY/ABSTRACT Half of estrogen receptor (ER?)-positive breast cancer patients treated with endocrine therapies manifest intrinsic or acquired therapy resistance. One-thi...
Regulation and function of exosomal cargo loading in cancer progression
Regulation and function of exosomal cargo loading in cancer progression Exosomes are 50-150 nm, endosome-derived, extracellular vesicles that are secreted by most cells.The exosome...
Elucidating the impact of DNA hypomethylation on genome organization and anti-tumor transcriptional programs.
PROJECT SUMMARY This proposed research career development program seeks to investigate the impact of DNA hypomethylation on genome organization and the mechanisms by which it drive...
Developing novel CAR T cell designs using combinatorial antigen detection
PROJECT SUMMARY/ABSTRACT Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead an independent laboratory-based translational r...
Differential biophysical properties of protein condensates formed by a tumor suppressor contribute to sexual dimorphism in cancer
PROJECT SUMMARY It remains incompletely understood why men are more likely to get and die from cancer than women.Tumor suppressor genes that escape from X-inactivation substantiall...
New Hybrid Molecular Modalities Comprised of DNA-Origami and Interfering Peptides as Inhibitors of Protein-Protein Interactions
PROJECT SUMMARY/ABSTRACT: New molecular modalities to target sites of protein-protein interaction with high affinity and specificity are desperately needed in cancer treatment.Bloc...
Interplay between tumor and microenvironment in bone metastasis
Prostate cancer (CaP) is the most commonly diagnosed cancer and the second leading cause of cancer death in men over the age of fifty. Bone is the primary site of metastasis in pat...
Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor Liposome
ABSTRACT The prognosis for patients with advanced stage ovarian or pancreatic cancer has remained dismal for decades.The poor response rates result, in part, from resistance to sal...
Exploiting Urine Derived DNA for the Assessment of Bladder Cancer using High Accuracy Sequencing
PROJECT SUMMARY Many attempts have been made to develop urine-based biomarkers for bladder cancer surveillance and monitoring. However, the most widely used approach, urine cytolog...
The Role of Base Excision Repair in Regulating DNA-Mediated Inflammatory Signaling Pathways
PROJECT SUMMARY Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of physiological systems and cause adverse phenotypes such as accelerat...
Breast cancer virotherapy
Breast cancer is the most frequently diagnosed cancer in women worldwide.Despite advances in early detection and treatment, a notable fraction of patients progress to metastatic di...
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Chemical manipulation of creatine kinases to treat acute myeloid leukemia
PROJECT SUMMARY: Over the last decade, essential metabolic dependencies of many cancers have been revealed.These dependencies have highlighted that certain nodes of metabolism are...
HULLK, a novel lncRNA that functions as a targetable oncogene in PCa
Abstract There remains a critical need for more effective therapies for prostate cancer and for castration resistant prostate cancer.While localized prostate cancer (PCa) has a fav...
Faithful mouse modeling of human lung cancer
Abstract Lung cancer is the leading cause of cancer-related deaths in both men and women with a 5-year survival rate of only 19%.Although PD-1 immune checkpoint blockade therapy ma...
Shifting the immune infiltrates in osteosarcoma lung metastases with locally targeted CSF-1Ris for combination therapies
PROJECT SUMMARY/ABSTRACT Osteosarcoma (OS) is the most common type of primary malignancy of the bone. OS metastasizes primarily to the lungs, with pulmonary disease being the leadi...
FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma
PROJECT SUMMARY Ewing Sarcoma Family of Tumors (ESFT) are bone and soft tissue cancers that affect children and adolescents.Surgery, radiation and multi-agent chemotherapy have imp...
Quantitative Analyses of HER2 Upregulation in Luminal Breast Cancer in Response to Neoadjuvant Endocrine Therapy
Project Description Endocrine therapy provides significant improvement in long-term outcomes for patients with estrogen receptor- positive (ER+) breast cancer (BC), also known as l...