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20,252 grants found
Showing 18,341 – 18,360 of 20,252 grants
Genetically faithful modeling of NUP98 rearrangement and co-alterations in acute myeloid leukemia
PROJECT SUMMARY Chromosomal translocations involving Nucleoporin 98 (NUP98) are observed in approximately 5% of pediatric acute myeloid leukemia (AML) and are associated with resis...
Characterization of the PKM2-RAS Interaction as a Novel Metabolic Vulnerability of RAS-driven Tumors
Project Summary/Abstract RAS is the most prevalent oncogene in human cancer and is disproportionately present in aggressive cancers, such as lung, pancreas, and colon adenocarcinom...
Elucidating the Regulation and Requirement of the NAD salvage pathway in CD8+ T Cell Exhaustion
Project Summary The development of checkpoint based cancer immunotherapy has revolutionized cancer treatment in the last decade.Although many otherwise untreatable patients have se...
Understanding Telomere Elongation Mechanisms in Cancer
Project Summary Malignant cancers must activate telomere maintenance mechanisms to achieve replicative immortality.Mutations in the human Protection Of Telomeres 1 (hPOT1) protein...
The role of HOXD13 in controlling Ewing sarcoma cell plasticity and metastasis
Project Summary Ewing sarcoma is an aggressive bone tumor that has a peak incidence in children and adolescents.Systemic chemotherapy and local control measures have improved survi...
Differential resistance mechanisms to monofunctional vs bifunctional alkylating agents in glioma
Project Summary Resistance to alkylating agents, including monofunctional temozolomide (TMZ) and bifunctional CCNU, remains a major obstacle to improving outcomes for patients with...
Mechanism of Transformation in T-Cell Lymphomas: Identification of Therapeutic Targets
Project Summary T-cell lymphomas (TCL) are a highly aggressive and heterogeneous group of non-Hodgkin lymphomas derived from post-thymic mature T- and NK-cells.Limited understandin...
Development of Advanced Oligonucleotides for Glioblastoma Therapeutics
PROJECT SUMMARY Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults.Despite significant progress being made in characterizing the geneti...
Mechanistic Studies of a Novel Vulnerability in Pediatric Cancer
Project Abstract Rhabdoid tumors (RT) are aggressive and lethal cancers that occur in young children. These tumors are resistant to chemotherapy and have a five-year survival rate...
[18F]-AraG -PET imaging to evaluate immunological response to checkpoint inhibitor therapy (CKI) in patients with advanced solid tumors
Contact PD/PI: Kummar, Shivaani PROJECT SUMMARY/ABSTRACT Immunotherapy, specifically checkpoint inhibitor (CKI) therapy, has resulted in dramatic and sustained tumor responses in p...
Precision Targeting of Myeloid Src-family Kinases in Acute Myelogenous Leukemia
Abstract. Acute myelogenous leukemia (AML) is a devastating hematologic cancer with limited treatment options.While diverse genetic changes are associated with AML, upregulation of...
Examining Mitochondria Dysfunction and Oxidative Stress in Senescence
PROJECT SUMMARY/ABSTRACT Cancer metastasis is responsible for 90% of cancer-related mortality world-wide.[1] A widely-held hypothesis is that during cancer progression, heterogeneo...
Dys-regulation of the MnSOD-Ac-ROS-HIF2a axis promotes IR / Cisplatin resistance phenotype
Summary - Metabolic stress, a hallmark of cancer, is an early event in tumorigenesis that accumulates in the cell from endogenous processes, exogenous conditions, and/or agents tha...
Metabolic basis of B cell lineage leukemia relapse
?DESCRIPTION (provided by applicant): Significance: Outcomes for patients with pre-B ALL have substantially improved over the past decades. However, this is not the case for 15-20%...
Elucidating Human Leukemia and T Cell Interactions within the Tumor Microenvironment
Project Summary/Abstract Leukemic relapse remains the major obstacle to successful allogeneic stem cell transplantation (allo-SCT).Here, donor lymphocyte infusion (DLI) seeks to re...
Lymph node regulation of metastatic fitness and reemergence
PROJECT SUMMARY Metastasis is the most dangerous stage of cancer, responsible for the vast majority of breast cancer-related deaths.Currently, we have no treatments that target met...
ETCTN Early Drug Development Opportunity Leadership program administrative supplement to Cancer Center Support Grant
This application is being submitted in response to the EDDOP Leadership Program via the mechanism PA-20- 272, ?Administrative Supplements to Existing NIH Grants and Cooperative Agr...
Developing newly combined therapeutic strategies for mature B cell lymphoma
While PD-1 blockade is effective in relapsed or refractory classical Hodgkin lymphoma (cHL) and in a subset of diffuse large B cell lymphomas (DLBCL) patients, a majority of B cell...
Harnessing the innate immunotransmitter cGAMP for anti-cancer therapy
PROJECT SUMMARY/ABSTRACT No change from original proposed activities.
Expanding the scope of protein degradation and stability using chemoproteomic platforms
Targeted protein degradation (TPD) has arisen as a powerful drug discovery platform for tackling the undruggable proteome by targeting specific proteins for proteasomal degradation...