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20,252 grants found
Showing 18,321 – 18,340 of 20,252 grants
Role of Chromatin Bridges in Activating Innate Immune Signaling following Failed Mitosis
PROJECT SUMMARY/ABSTRACT Abnormal chromatin structures produced by errors in cell division can cause cell death, propagate genetic instability and, potentially, induce inflammatory...
Exploring the Role of Drp1 in Colorectal Cancer
Abstract - Exploring the Role of Drp1 in Colorectal Cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Approximately 150,000 new c...
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONS
PROJECT SUMMARY Mutations that inactivate DNA repair factors increase genome instability and cancer susceptibility.Predicting the phenotypic effects of mutations is confounded by p...
Network mechanisms and bioengineering of precision immunotherapies for glioblastomas
Project Summary/Abstract Glioblastoma multiforme (GBM) is the most common and lethal malignancy of the human central nervous system (CNS). This devastating disease has a median ove...
Gain-of-function mutant p53 and metabolic reprogramming in colorectal cancer
Tumor suppressor p53 plays a central role in tumor prevention. p53 is frequently mutated in human cancer, including colorectal cancer (CRC).Many mutant p53 (mutp53) proteins not on...
Defining the role of BARD1 in nucleosomal ubiquitylation
PROJECT SUMMARY BARD1 (BRCA1-Associated RING Domain protein-1) is an essential partner of the breast and ovarian cancer tumor-suppressor protein, BRCA1, and is included in a panel...
2021 Annual Meeting of the American Society for Investigative Pathology
The purpose of this proposal is to seek support for the 2021 Annual Meeting of the American Society for Investigative Pathology (ASIP), which will be held in conjunction with the E...
Dissecting the role of clonal evolution in NPM1-mutant AML
Project Summary/Abstract Candidate: I am a postdoctoral fellow in the lab of Dr. Ross Levine in the Human Oncology & Pathogenesis Program at Memorial Sloan Kettering Cancer Cen...
A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable HCC Patients
SUMMARY Surgical resection is curative in hepatocellular carcinoma (HCC).Unfortunately, surgical cases often suffer from early recurrence (up to 50% in two years), which leads to d...
Mechanisms regulating the formation of a pro-metastatic niche and tumor cell dormancy in the liver
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is the third-leading cause of cancer-related deaths in the United States. For patients with PDAC, metastasis is the major cause of...
Estrogen receptor fusions genes as drivers of endocrine resistance in breast cancer
Anti-estrogen therapy is key to the prevention and treatment of estrogen receptor (ER, ESR1) positive breast cancer, but therapy resistance occurs in up to a half of cases resultin...
Credentialing Models of Invasive Lobular Breast Cancer for Translational Research
Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after the more common invasive ductal breast cancer (IDC).In 2020, ILC will aff...
DNA Methylation Markers, Genes and Breast Cancer Risk
PROJECT SUMMARY Genome-wide association studies (GWAS) have identified common variants in ~200 genetic loci associated with breast cancer risk.However, it is difficult to translate...
Define the Role of POT1 Mutation in Genome Instability and Cancer
Project Summary The goal of this proposal is to investigate the mechanism by which alteration in the telomere binding protein POT1 results in tumorigenesis.Mutations in POT1 (>1...
Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias
PROJECT SUMMARY The mixed-lineage leukemia (MLL) gene rearrangements account for approximately 80% of infant acute lymphoblastic leukemia (ALL) and 35-50% of infant acute myeloid l...
CSHL 2021 Eukaryotic mRNA Processing Conference
COLD SPRING HARBOR LABORATORY CONFERENCE EUKARYOTIC mRNA PROCESSING AUGUST 24 - 28, 2021 ABSTRACT The proposed conference on ?Eukaryotic mRNA Processing? will convene scientists st...
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma
Targeting Systems Vulnerabilities in the G?q/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma G protein-coupled receptors (GPCRs) represent the larges...
Targeting endolysosomal trafficking to increase delivery of antisense oligonucleotides to tumors
PROJECT SUMMARY/ABSTRACT Antisense oligonucleotides (ASO) are the ultimate platform technology that could cripple lethal, drug-resistant tumors by targeting ?undruggable? oncogenes...
Autoantibody-based early detection of small-cell lung cancer by immunoimaging
Project Summary/Abstract Small-cell lung cancer (SCLC) is an aggressive and deadly cancer.Over 2/3 of SCLC are diagnosed at later stages, where patients are expected to survive for...
Ferroptosis as a Modulator of Checkpoint Inhibitor Immunotherapy
Melanoma is the deadliest form of skin cancer and expected to cause 8000 deaths in the United States in 2019.Although treatment with anti-CTLA-4 and anti-PD-1 immune checkpoint inh...