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20,252 grants found
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Targeting the autophagy-lysosome system to block pancreatic cancer
PROJECT SUMMARY Cancer cells co-opt autophagy - an evolutionarily conserved cellular recycling pathway - to maintain metabolic fitness.Prior studies have shown that Pancreatic Duct...
Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon Radiotherapy
Project Summary Radiotherapy (RT) aims to deliver tumoricidal dose to clinical target volume (CTV) while sparing organs at risk (OAR), for which proton and photon beams are natural...
Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis
ABSTRACT Gastric cancer (GC) is the fifth most common malignancy and the third most lethal cancer worldwide, with a 5-year survival rate of 5-10% in advanced stages.The long-term g...
Integrative single cell analyses of inflammation-derived circulating hybrid cells to identify aggressive disease
PROJECT SUMMARY The lifetime risk for acquiring colorectal cancer (CRC) is 7%, with an astounding rate of disease recurrence in 32% of newly diagnosed patients after their ?success...
Mechanistic maps of adaptive responses to therapeutic stress to optimize combination therapies.
Summary.In triple-negative breast cancer and high-grade serous ovarian cancer, the emergence of resistance to therapy is virtually inevitable and contributes to dismal long-term pa...
Autophagy Heterogeneity and Tumor Metastasis
The goal of this project is to investigate the intratumoral heterogeneity of autophagy activity in breast cancer metastasis.Autophagy is a highly conserved lysosomal degradation pa...
DNA Damage and Immunogenicity in Ewing Sarcoma
The goal of this career development award is for the applicant to expand her knowledge and technical expertise in tumor immunology and bioinformatic analyses in order to apply thes...
Does obesity influence protein quality control in endometrial cancer?
PROJECT SUMMARY/ABSTRACT Research Project: Excess body weight is a contributing factor in up to 20% of all cancer deaths in women.In particular, endometrial cancer (EC) incidence h...
Targeting Epigenomic Regulators at the Replication Fork in PDAC
Pancreatic adenocarcinoma (PDAC) remains a therapeutic challenge, making the identification of new targets and development of novel treatment strategies for this disease of paramou...
Automated Assessment for Robotic Suturing Utilizing Deep Learning Algorithms
ABSTRACT Medical errors are the third leading cause of death in the US at a cost of $20 billion annually. Surgical complications account for a third of these deaths and cost. Surgi...
Elucidating pro-metastatic collagen modifying activities of lysyl hydroxylase 2
As they progress, malignant tumors accumulate cross-linked collagen fibrils that enhance matrix stiffness, thereby activating collagen receptors that trigger cancer cell invasion a...
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
PROJECT SUMMARY Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanisms, res...
Synthetic epigenetic circuits: tunable cell fate switches controlled by dynamic and combinatorial inputs
PROJECT SUMMARY Cellular differentiation is controlled by epigenetic regulatory systems that integrate multiple sensory inputs over time to direct long-term cell fate decisions. Ha...
A novel determinant of prostate cancer growth
Project Summary/Abstract Prostate cancer (CaP) will cause the deaths of more than 33,000 American men in 2020 because systemic treatments for metastatic CaP fail.Actionable targets...
Mechanisms of metabolic stress-induced transcriptional regulation in prostate cancer
Metastatic prostate cancer (PCa) remains a major clinical challenge.Although androgen deprivation therapy (ADT) is effective in treating PCa, majority of the patients quickly devel...
Mutational cooperativity in TET2-associated hematological malignancies.
Project Summary/ Abstract Peripheral T cell lymphoma (PTCL) represents a group of aggressive blood cancers derived from mature T cells, and remains as a high unmet clinical need wi...
Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults
Project Summary Although smoking prevalence has declined to 13.7% among U.S. adults, smoking rates are much higher among socioeconomically disadvantaged adults. Lung cancer, which...
Investigating the role of EZH2 as a therapeutic target in colorectal cancers
Abstract The Polycomb Repressive Complex 2 (PRC2) is a highly conserved developmental regulator that maintains cellular identity by dynamically silencing key genes involved in diff...
Genetic Determinants of Evolutionary Trajectories and Clinical Course in Pancreatic Cancer
PROJECT SUMMARY Genetic intratumoral heterogeneity (gITH) has been associated with cancer progression and is thought to be a major contributor to treatment resistance.However, the...
Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...