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20,252 grants found
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Minibeam Radiation Therapy Enhanced Delivery of Nanoparticle Anticancer Agents to Pancreatic Cancer Tumors
PROJECT SUMMARY / ABSTRACT: Nanoparticles (NPs) hold great promise for delivering more effective and safer cancer treatment than the small molecule drugs that are commonly used. Th...
Post-doctoral Training Program in Cancer Metabolism and Tumor-host Interactions
Rutgers Cancer Institute of New Jersey (RCINJ) provides an outstanding environment for training in basic, clinical, behavioral or population-based cancer research and brings togeth...
Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial
PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is n...
Identification of TR4 Modulators for Treatment of Cushing Disease.
ABSTRACT Cushing Disease (CD) is caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor that causes excess adrenal-derived cortisol.It is a life-threatening ?orp...
Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem
PROJECT SUMMARY Ovarian cancer is a silent killer that strikes with few, if any, symptoms. By the time a woman knows she has it, the cancer is often advanced and the outlook grim....
Lung Resident Mesenchymal Cells in the Pre-Metastatic Niche Formation
PROJECT SUMMARY/ABSTRACT Metastatic disease remains the major cause of cancer-related death. Among the vital organs to which solid tumors metastasize, the lung is one of the most c...
Role of Transcription Factor ADP-ribosylation in Breast Cancer Biology
Project Summary/Abstract The molecular heterogeneity of cancers poses a major hurdle for treatment and drug discovery efforts.Previous studies have addressed this challenge by char...
Targeting allosteric scaffolding functions of Aurora kinase A in cancer
ABSTRACT Neuroblastoma is the most common solid tumor in infants.About 25% of patients have high-risk neuroblastoma, a devastating disease with poor prognosis and few treatment opt...
Targeting Lymph Node Dependent Immune Tolerance in Cancer
Project Summary Background: Malignant melanoma and pancreatic ductal adenocarcinoma (PDAC) typically spread to lymph nodes (LNs) prior to outgrowth in distant tissues.While metasta...
Mechanisms of tumor initiation upon disruption of the Rb/E2f interaction
ABSTRACT E2f (E2f1-8) transcription factors are critical regulators of cell cycle and their activity is physically regulated by Rb family proteins (Rb, p107 and p130). Disruption o...
Predicting Relapse at the Time of Diagnosis in Acute Lymphoblastic Leukemia
PROJECT SUMMARY Relapse is the major cause of cancer related mortality in children with leukemia.Despite improvements in overall survival for children with B-cell progenitor acute...
Dynamic 3D chromatin remodeling in acute leukemia - Resubmission - 1
ABSTRACT Recent advances in chromatin conformation capture techniques have revolutionized our understanding of chro- matin organization and have provided novel insights at an unpre...
Predicting sensitivity and resistance in RET-driven cancers
Selpercatinib (LOXO-292) is a highly active selective RET inhibitor explored on an ongoing registrational program (LIBRETTO-001 phase 1/2 trial) in RET-dependent cancers (US FDA ap...
Regulation of DGAT - dependent lipogenesis in colonic epithelial growth
Abstract Obesity is characterized by systemic lipid accumulation, inflammation, and enhanced tumorigenesis in different tissues, including colon. With obesity, intracellular lipid...
Mechanisms of Epigenetic Plasticity in PDAC
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly human cancers and in ~95% of cases driven by oncogenic mutations of Kras.Unfortunately, attempts to directly inhib...
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have revolutionized lung cancer clinical practice.Lung adenocarcinomas harbor frequent mutations/amplifications/fusio...
Improving efficacy of radioiodine treatment of thyroid cancer
Patients with advanced thyroid cancer are frequently refractory to radioiodine (RAI) therapy.Oncoproteins that constitutively activate MAPK signaling suppress expression of genes t...
Deconstructing and targeting aneuploidy in human cancer - Resubmission - 1
Summary Aneuploidy?the presence of chromosome gains and losses?is very rare in normal tissues but occurs in more than 80% of human tumors, especially in solid tumors.A high level o...
Developing and Testing a Digital Toolkit to Improve Colorectal Cancer Screening Rates in Federally Qualified Health Centers
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer death in the United States. National guidelines recommend that average risk people receive regular CRC...
Enhancing the public health benefits of mammography screening by informing women of both breast cancer and breast arterial calcification results: A randomized trial to promote cardiovascular health
Breast mammography is one of the most successful cancer screening tools in the cancer prevention arsenal. 37 million women in the US will receive a mammogram this year, and followi...