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20,252 grants found
Showing 18,241 – 18,260 of 20,252 grants
Role of Transcription Factor ADP-ribosylation in Breast Cancer Biology
Project Summary/Abstract The molecular heterogeneity of cancers poses a major hurdle for treatment and drug discovery efforts. Previous studies have addressed this challenge by cha...
Joint receptor and protein expression immunophenotyping through split-pool barcoding
Single-cell immune repertoire sequencing can provide invaluable information about the response of the adaptive immune system to disease and therapy. However, existing approaches fo...
Lipid metabolism as a therapeutic vulnerability in BET inhibitor-resistant medulloblastoma
Project Summary/Abstract MYC-driven medulloblastomas are a particularly devastating group of pediatric brain tumors that exhibit resistance and continued progression despite standa...
The role of CaMKK2 in tumor-infiltrating natural killer cells
Abstract: Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is an important regulator of cellular metabolism. Though classically associated with neurons and macrophages...
The selective advantage of mismatch repair loss in colonic stem cells
Project Summary Lynch syndrome (LS) is a hereditary disease that predisposes patients to colorectal, endometrial, ovarian and other cancers. LS is caused by inherited mutations in...
Improving efficacy of radioiodine treatment of thyroid cancer
Patients with advanced thyroid cancer are frequently refractory to radioiodine (RAI) therapy. Oncoproteins that constitutively activate MAPK signaling suppress expression of genes...
Post-doctoral Training Program in Cancer Metabolism and Tumor-host Interactions
Rutgers Cancer Institute of New Jersey (RCINJ) provides an outstanding environment for training in basic, clinical, behavioral or population-based cancer research and brings togeth...
SMARCB1 regulated SWI/SNF complex function in Malignant Rhabdoid Tumors
PROJECT SUMMARY A research program will be undertaken to study SMARCB1-regulated SWI/SNF complex function in malignant rhabdoid tumors. Over the past few years, major cancer genome...
Structure-activity relationships governing mammalian SWI/SNF chromatin remodeling activity as a function of chromatin state
PROJECT SUMMARY Recent whole-exome sequencing studies in human cancer and neurodevelopmental disorders have unmasked frequent mutations in genes encoding chromatin regulatory prote...
Lung Resident Mesenchymal Cells in the Pre-Metastatic Niche Formation
PROJECT SUMMARY/ABSTRACT Metastatic disease remains the major cause of cancer-related death. Among the vital organs to which solid tumors metastasize, the lung is one of the most c...
Gain-of-function mutant p53 and metabolic reprogramming in colorectal cancer
Tumor suppressor p53 plays a central role in tumor prevention. p53 is frequently mutated in human cancer, including colorectal cancer (CRC). Many mutant p53 (mutp53) proteins not o...
New Hybrid Molecular Modalities Comprised of DNA-Origami and Interfering Peptides as Inhibitors of Protein-Protein Interactions
PROJECT SUMMARY/ABSTRACT: New molecular modalities to target sites of protein-protein interaction with high affinity and specificity are desperately needed in cancer treatment. Blo...
Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon Radiotherapy
Project Summary Radiotherapy (RT) aims to deliver tumoricidal dose to clinical target volume (CTV) while sparing organs at risk (OAR), for which proton and photon beams are natural...
Does obesity influence protein quality control in endometrial cancer?
PROJECT SUMMARY/ABSTRACT Research Project: Excess body weight is a contributing factor in up to 20% of all cancer deaths in women. In particular, endometrial cancer (EC) incidence...
Molecular mechanism of EGFRs protein-protein interaction inhibition by a grafted peptide in NSCLC
Project Summary: The long-term objective of this research project is to understand the role of dimerization in extracellular domains (ECD) of epidermal growth factor receptors (EGF...
Efficacy of a Mindfulness-Based Stress Management Program for Allogeneic HCT Caregivers
PROJECT SUMMARY/ABSTRACT Caring for an allogeneic hematopoietic stem cell transplant (HCT) patient is a significant responsibility, involving a commitment to be available 24/7 up t...
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers
ABSTRACT Clonal hematopoesis (CH) defined as the presence of acquired mutations detectable in peripheral blood of normal healthy individuals without hematologic malignancies (HM) h...
Metabolic Contributions of Individual Cellular Compartments to the Diversity of the Tumor Microenvironment in Renal Cell Carcinoma
PROJECT SUMMARY Deregulating cellular energetics and avoiding immune destruction are considered hallmarks of cancer. Stimulating anti-tumor immunity is now a chief goal of cancer t...
CRL3KEAP1 complex licenses genotoxic stress-induced tumor cell death
PROJECT SUMMARY/ABSTRACT This application is responsive to PA-17-449: The Interplay of Cell Death Pathways in Cancer Cell Survival and Resistance to Therapy (R21). In general, geno...
Credentialing Models of Invasive Lobular Breast Cancer for Translational Research
Invasive lobular breast cancer (ILC) is the second most common histological subtype of breast cancer after the more common invasive ductal breast cancer (IDC). In 2020, ILC will af...