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20,252 grants found
Showing 18,221 – 18,240 of 20,252 grants
Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer
Project Summary Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer Women with germline mutations in BRCA1 and BRCA2 (BRCA carriers) are at high ris...
Developing novel CAR T cell designs using combinatorial antigen detection
PROJECT SUMMARY/ABSTRACT Candidate: The applicant, Greg Allen, MD/PhD, is a medical oncologist at UCSF with a long-term goal to lead an independent laboratory-based translational r...
Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma
Sarcomatoid renal cell carcinoma (sRCC) represents an aggressive group of renal epithelial tumors characterized by histopathological features of epithelial–mesenchymal plasticity (...
Defining the role of BARD1 in nucleosomal ubiquitylation
PROJECT SUMMARY BARD1 (BRCA1-Associated RING Domain protein-1) is an essential partner of the breast and ovarian cancer tumor-suppressor protein, BRCA1, and is included in a panel...
Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor Liposome
ABSTRACT The prognosis for patients with advanced stage ovarian or pancreatic cancer has remained dismal for decades. The poor response rates result, in part, from resistance to sa...
Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem
PROJECT SUMMARY Ovarian cancer is a silent killer that strikes with few, if any, symptoms. By the time a woman knows she has it, the cancer is often advanced and the outlook grim....
Estrogen receptor fusions genes as drivers of endocrine resistance in breast cancer
Anti-estrogen therapy is key to the prevention and treatment of estrogen receptor (ER, ESR1) positive breast cancer, but therapy resistance occurs in up to a half of cases resultin...
Integrative single cell analyses of inflammation-derived circulating hybrid cells to identify aggressive disease
PROJECT SUMMARY The lifetime risk for acquiring colorectal cancer (CRC) is 7%, with an astounding rate of disease recurrence in 32% of newly diagnosed patients after their “success...
Sphingolipid Signaling and Chemotherapy-Induced Peripheral Neurotoxicity
PROJECT SUMMARY/ABSTRACT Chemotherapy induced peripheral neuropathy is a common dose-limiting toxicity that can reduce therapeutic effectiveness and impact quality of life for canc...
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences
Project Abstract Live cell reporters of genetic changes in stiff vs soft surroundings – causes & consequences Solid tumors are often palpably stiff and more constrained in 3D g...
Exploring the Role of Drp1 in Colorectal Cancer
Abstract - Exploring the Role of Drp1 in Colorectal Cancer. Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Approximately 150,000 new c...
Targeting Lipid Metabolism in Colorectal Cancer
PROJECT SUMMARYMetastasis is the main cause of death from solid tumors including colorectal cancer (CRC). Our long-term goal is to develop more selective therapeutic options to pre...
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma
Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma G protein-coupled receptors (GPCRs) represent the larges...
INVESTIGATING THE ROLE OF HSP90 IN SHAPING THE CONSEQUENCES OF BRCA1 MUTATIONS
PROJECT SUMMARY Mutations that inactivate DNA repair factors increase genome instability and cancer susceptibility. Predicting the phenotypic effects of mutations is confounded by...
TRANSCRIPTIONAL REPROGRAMMING OF ESR1 MUTANT BREAST CANCER IN METASTASIS AND TREATMENT RESISTANCE
Project Summary Up to 1 in 8 women in the United States will develop invasive breast cancer in their lifetime, with 70-80% of cases being estrogen receptor positive (ER+). These ca...
A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep
Project Summary Over 50% of pediatric cancer patients report problems with their sleep, characterized by insomnia disorder symptoms. This results in considerable physical and psych...
Differential resistance mechanisms to monofunctional vs bifunctional alkylating agents in glioma
Project Summary Resistance to alkylating agents, including monofunctional temozolomide (TMZ) and bifunctional CCNU, remains a major obstacle to improving outcomes for patients with...
Role of Chromatin Bridges in Activating Innate Immune Signaling following Failed Mitosis
PROJECT SUMMARY/ABSTRACT Abnormal chromatin structures produced by errors in cell division can cause cell death, propagate genetic instability and, potentially, induce inflammatory...
Optimizing Therapeutic STING Agonism in Triple Negative Breast Cancer
PROJECT SUMMARY Despite the therapeutic promise of STING agonists in cancer, first in human studies have been hampered by lack of precision therapy and issues with drug delivery. M...
Harnessing Rare Variants for Tumor Classification
Abstract This project concerns how to extract clinically actionable information for diagnostic purposes from mutational patterns observed from tumor sequencing panels that are incr...