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20,252 grants found
Showing 18,201 – 18,220 of 20,252 grants
Developing and Testing a Digital Toolkit to Improve Colorectal Cancer Screening Rates in Federally Qualified Health Centers
PROJECT SUMMARY/ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer death in the United States. National guidelines recommend that average risk people receive regular CRC...
Understanding the Guideline-Discordant Use of Bone Modifying Agents in Prostate Cancer
PROJECT SUMMARY Bone-modifying agents (BMAs) can improve quality-of-life in metastatic prostate cancer. The BMAs zoledronic acid and denosumab prevent bone fractures among men with...
Dissecting new mechanisms of lysosome quality control in health and disease
PROJECT SUMMARY Lysosomes function as critical nodes for macromolecular recycling, metabolic rewiring, and pro-growth signaling in cells. Accordingly, defects in lysosome function...
A Simulation Modeling Study to Support Personalized Breast Cancer Prevention and Early Detection in High-Risk Women
Abstract: Personalized care is complex in this unprecedented era of discovery and ‘big data’. The proposed study focuses on the real-world choices facing over 100,000 US women each...
Development of Advanced Oligonucleotides for Glioblastoma Therapeutics
PROJECT SUMMARY Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite significant progress being made in characterizing the genet...
Molecular mechanisms of T cell responses to a clonal neoantigen resulting from a mutated driver oncogene.
PROJECT SUMMARY/ABSTRACT Immunotherapy induces durable remissions in a subset of patients with highly mutated cancers. However, most cancers are modestly mutated and fail to respon...
Can a subset of patients with HER2+ metastatic breast cancer be cured?
PROJECT SUMMARY Because of the development of highly effective HER2-targeted therapies over the past two decades, most patients now diagnosed with stage I-III HER2+ breast cancer (...
Understanding Telomere Elongation Mechanisms in Cancer
Project Summary Malignant cancers must activate telomere maintenance mechanisms to achieve replicative immortality. Mutations in the human Protection Of Telomeres 1 (hPOT1) protein...
Geranylgeranyl diphosphate synthase inhibitor therapy for multiple myeloma
Project Summary Multiple myeloma (MM) is an incurable bone marrow (BM) cancer characterized by the production of monoclonal protein (MP). Development of drug resistance and off-tar...
Exploring the concept of dyadic health in Thai couples coping with breast cancer: A preliminary study of a partnered approach to physical activity in breast cancer survivors and spouse care partners
The proposed supplement application responds to the Notice of Special Interest (NOSI) identified in NOT-CA- 21-058 for projects to stimulate and strengthen global cancer survivorsh...
Proteomic, Genomic, and Longitudinal Pathways to Ovarian Cancer Biomarker Discovery
Project Summary This administrative supplement seeks support for administration of the Uterine Lavage Study by the principal investigator and a research coordinator.Since the study...
Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon Radiotherapy
Project Summary Radiotherapy (RT) aims to deliver tumoricidal dose to clinical target volume (CTV) while sparing organs at risk (OAR), for which proton and photon beams are natural...
Elucidating the impact of DNA hypomethylation on genome organization and anti-tumor transcriptional programs
PROJECT SUMMARY This proposed research career development program seeks to investigate the impact of DNA hypomethylation on genome organization and the mechanisms by which it drive...
Dynamic 3D chromatin remodeling in acute leukemia - Resubmission - 1
ABSTRACT Recent advances in chromatin conformation capture techniques have revolutionized our understanding of chro- matin organization and have provided novel insights at an unpre...
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Mechanisms of tumor initiation upon disruption of the Rb/E2f interaction
ABSTRACT E2f (E2f1-8) transcription factors are critical regulators of cell cycle and their activity is physically regulated by Rb family proteins (Rb, p107 and p130). Disruption o...
Elucidating Human Leukemia and T Cell Interactions within the Tumor Microenvironment
Project Summary/Abstract Leukemic relapse remains the major obstacle to successful allogeneic stem cell transplantation (allo-SCT). Here, donor lymphocyte infusion (DLI) seeks to r...
Two photon fluorescence microscopy for dermatologic surgery and biopsy
Medicare reimburses over 5 million biopsies resulting in 1.5 million surgical procedures annually for nonmelanoma skin cancer (NMSC). Despite its burden on the health care system,...
Targeting the IL-33/ST2 Pathway in Colorectal Cancer Immunotherapy
Summary/Abstract: I am a postdoctoral fellow at Indiana University who has developed a unique set of skills in tumor immunology and cancer immunotherapy. Throughout my graduate and...
Targeting Lymph Node Dependent Immune Tolerance in Cancer
Project Summary Background: Malignant melanoma and pancreatic ductal adenocarcinoma (PDAC) typically spread to lymph nodes (LNs) prior to outgrowth in distant tissues. While metast...