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20,252 grants found
Showing 18,181 – 18,200 of 20,252 grants
Interplay between tumor and microenvironment in bone metastasis
Prostate cancer (CaP) is the most commonly diagnosed cancer and the second leading cause of cancer death in men over the age of fifty. Bone is the primary site of metastasis in pat...
Deconstructing and targeting aneuploidy in human cancer - Resubmission - 1
Summary Aneuploidy—the presence of chromosome gains and losses—is very rare in normal tissues but occurs in more than 80% of human tumors, especially in solid tumors. A high level...
A Multi-pronged Computational Approach to Advance Kinase Drug Discovery
Project Summary/Abstract In recent years, computing speed has exponentially increased; however, the potential of computational ap- proaches to accelerate drug discovery has not bee...
Robot-Assisted Personalized Prostate Biopsy
PROJECT SUMMARY/ABSTRACT Prostate cancer (PCa) is the most commonly diagnosed type of cancer and the second leading cause of cancer related death among US men. The best current est...
Contribution of ERa/PR Crosstalk to Endocrine Therapy Resistance in the Context of ERa-Y537S
PROJECT SUMMARY/ABSTRACT Half of estrogen receptor (ERα)-positive breast cancer patients treated with endocrine therapies manifest intrinsic or acquired therapy resistance. One-thi...
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
PROJECT SUMMARY Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanisms, res...
Development of an NTSR1-Targeted Radiotherapeutic for Colorectal Cancer
Objective: More effective treatment options are needed across all clinical stages of colorectal cancer (CRC), from eliminating residual disease after surgery, improving surgical ca...
Exploiting Urine Derived DNA for the Assessment of Bladder Cancer using High Accuracy Sequencing
PROJECT SUMMARY Many attempts have been made to develop urine-based biomarkers for bladder cancer surveillance and monitoring. However, the most widely used approach, urine cytolog...
Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1
PROJECT SUMMARY While the technological enterprise of magnetic resonance imaging (MRI) generates a host of biomarkers of the tumor environment, in particular for breast cancer, pre...
Targeting the autophagy-lysosome system to block pancreatic cancer
PROJECT SUMMARY Cancer cells co-opt autophagy - an evolutionarily conserved cellular recycling pathway - to maintain metabolic fitness. Prior studies have shown that Pancreatic Duc...
Mechanisms of tumor microenvironmental regulation of T-cell infiltration in melanoma
Project Summary Melanoma is the deadliest form of skin cancer, with over 100,000 new cases and 6,000 deaths predicted in the United States in 2020. While the advent of immune check...
Breast cancer virotherapy
Breast cancer is the most frequently diagnosed cancer in women worldwide. Despite advances in early detection and treatment, a notable fraction of patients progress to metastatic d...
Investigating Transcriptional Elongation and Nuclear RNA Surveillance in Melanoma
Project Summary Metastatic melanoma, a cancer derived from pigment-producing melanocytes, is the deadliest type of skin cancer. Metastatic melanoma that is refractory or resistant...
DNA Damage and Immunogenicity in Ewing Sarcoma
The goal of this career development award is for the applicant to expand her knowledge and technical expertise in tumor immunology and bioinformatic analyses in order to apply thes...
Characterization of the PKM2-RAS Interaction as a Novel Metabolic Vulnerability of RAS-driven Tumors
Project Summary/Abstract RAS is the most prevalent oncogene in human cancer and is disproportionately present in aggressive cancers, such as lung, pancreas, and colon adenocarcinom...
Smoking Cessation in Persons with Mental Health Conditions: Exploring the Role of Family and Friends
PA-20-251 Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research (Parent F31-Diversity). Smoke...
Roles of Coactivator-Associated Arginine Methyltransferase 1 in B cell activation and lymphomagenesis
PROJECT SUMMARY Follicular lymphoma (FL) and diffuse large B cell lymphoma (DLBCL) are the most common germinal center (GC)- derived Non-Hodgkin B cell lymphomas (BCLs). Although i...
Human papillomavirus in HIV associated lung cancers
SUMMARY In recent years, the incidence of AIDS-defining cancers has dramatically decreased due to the HAART therapy. In contrast, the incidence of the non-AIDS-defining cancers (NA...
Network mechanisms and bioengineering of precision immunotherapies for glioblastomas
Project Summary/Abstract Glioblastoma multiforme (GBM) is the most common and lethal malignancy of the human central nervous system (CNS). This devastating disease has a median ove...
Investigating the role of EZH2 as a therapeutic target in colorectal cancers
Abstract The Polycomb Repressive Complex 2 (PRC2) is a highly conserved developmental regulator that maintains cellular identity by dynamically silencing key genes involved in diff...