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20,252 grants found
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Mechanism underlying how host B cells empower adoptively transferred Th17 cells with durable tumor immunity
PROJECT SUMMARY Adoptive T cell transfer (ACT) therapy mediates potent immunity in some patients with aggressive malignancies, but many individuals do not respond or relapse. One r...
Leveraging CD26high Meso-CAR T cells in patients with advanced pancreatic cancer
PROJECT SUMMARY This project translates an innovative, chimeric antigen receptor (CAR) T cell therapy to patients with pancreatic ductal adenocarcinoma (PDAC). We posit efficacy of...
Targeted EGFR for basal subtype pancreatic cancer
Abstract We and others have shown that basal tumors, which comprise
Novel taxane-site tubulin ligands with a dual apoptosis and senescence-inducing mechanism of action
PROJECT SUMMARY Senescence, like apoptosis, is an established tumor suppressive mechanism that protects against cancer development by inducing sustained proliferative arrest. Apopt...
Epigenetic Mechanisms and the Treatment of Cancer
ABSTRACT Support is requested for a Keystone Symposia conference entitled Epigenetic Mechanisms and the Treatment of Cancer, organized by Drs. Tony Kouzarides, Rab Prinjha and Mari...
PRISMA AND EXTEND 2.0 FOLLOW-UP OF STUDY PARTICIPANTS
Human papillomavirus (HPV) infection is necessary for the development of cervical cancer. Worldwide, infection with HPV types 16 and 18 account for approximately 70% of cervical ca...
Targeting isocitrate dehydrogenase mutations by enzyme hyperactivation
PROJECT SUMMARY/ABSTRACT Mutations in isocitrate dehydrogenase (IDH) enzymes are hallmarks of a variety of deadly cancers, including acute myeloid leukemia (AML), glioma, cholangio...
Forging a new path with cyclin-dependent kinase inhibitors to treat epithelioid hemangioendothelioma
PROJECT SUMMARY Epithelioid hemangioendothelioma (EHE) is a rare monogenic cancer caused by a reciprocal chromosomal translocation that generates the TAZ(WWTR1)–CAMTA1 (TC) fusion...
Targeting NEK2 to potentiate standard of care therapies for breast cancer
PROJECT SUMMARY/ABSTRACT Triple Negative Breast Cancer (TNBC) is a highly aggressive disease subtype that conveys poor patient outcomes. While targeted therapies exist and are high...
Developing a novel therapeutic strategy for overcoming resistance to PD-1 blockade in Triple-negative breast cancer
PROJECT SUMMARY / ABSTRACT Triple negative breast cancer (TNBC) is a highly aggressive cancer that has a poor prognosis and limited treatment due to the high propensity for metasta...
Bispecific drug-conjugates for treating colorectal cancer
ABSTRACT: Tumor heterogeneity and cancer stem cell (CSC) plasticity present a significant challenge to the effective treatment of colorectal cancer (CRC). Several studies have esta...
Jumonji enzyme action in hepatocellular carcinoma onset
Patients with fatty liver disease have a high risk of progressing to liver cancer, including hepatocellular carcinoma. At the molecular level, two major changes occur in hepatocyte...
weSipSmarter: An efficacy trial to reduce sugary beverages among rural Head Start parent-child dyads
Project Summary: Sugary drinks are the largest single source of calories in the US diet and contribute approximately 8% and 7% of total energy intake for US youth and adults, respe...
Identification and structural basis of a potential licensing factor of the Integrator cleavage module
Abstract: Transcription is one of the first steps in gene expression, and the many protein factors involved must be tightly regulated to correctly carry out cellular processes. The...
Non-canonical function of transcription cofactor MLL1 in cancer
Project Summary Aberrations of chromatin modifying enzymes are frequently found in a wide spectrum of human diseases. Among them, histone H3 K4 methyltransferase mixed lineage leuk...
Role of LRG1 in colorectal cancer tumorigenesis
Patients with metastatic colorectal cancer (mCRC) have substantially worse outcomes than those with primary and localized CRC. Over 80% of CRC metastases occur in the liver, which...
MIZ1 Activation in Triple-negative Breast Cancer Racial Disparities
Triple-negative breast cancer (TNBC) is an aggressive and molecularly heterogeneous subtype of breast cancer that frequently exhibits resistance to chemotherapy leading to poorer c...
Secondary Molecular Imaging (SMI) for head and neck cancer
Project Summary The current standard of care for evaluation and surveillance of regional and metastatic disease in advanced stage head and neck squamous cell carcinoma (HNSCC) is 1...
Modeling and analysis of curative combination therapy for Diffuse Large B-Cell Lymphoma
Abstract This goal of this project is to develop computer simulations of combination therapy for aggressive lymphomas, and apply them to understand past positive and negative trial...
Cell cycle paths as a framework for understanding drug resistance in tumor cell subpopulations
SUMMARY / ABSTRACT Multiple clinical trials have shown that combining anti-estrogen therapy with CDK4/6 inhibitor therapy improves progression-free survival in ER+/HER2- breast can...