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20,252 grants found
Showing 18,161 – 18,180 of 20,252 grants
Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer
Project Summary Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancer Women with germline mutations in BRCA1 and BRCA2 (BRCA carriers) are at high ris...
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have revolutionized lung cancer clinical practice. Lung adenocarcinomas harbor frequent mutations/amplifications/fusi...
Understanding and exploiting novel therapeutic vulnerabilities of RIT1-driven lung cancer
PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have revolutionized lung cancer clinical practice. Lung adenocarcinomas harbor frequent mutations/amplifications/fusi...
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences
Project Abstract Live cell reporters of genetic changes in stiff vs soft surroundings – causes & consequences Solid tumors are often palpably stiff and more constrained in 3D g...
Targeting Mitochondrial Redox Capacity to Overcome Cancer Subtype that Regrowth After Radiation
PROJECT SUMMARY Radiation therapy (RT) is widely used to treat localized prostate cancer (PCa). However, cancer cells often develop resistance to RT through unknown mechanisms, res...
Davoli/Camacho-Hernandez Diversity Supplement
Summary of the funded parent grant Aneuploidy—the presence of chromosome gains and losses—is very rare in normal tissues but occurs in more than 80% of human tumors, especially in...
Optimizing Dual-Targeted and Dual-Armored CAR T Cells for Small Cell LungCancer
ABSTRACT A patient's own T cells can be modified using gene therapy technology to express receptors, termed chimeric antigen receptors or CARs, which allow these immune T cell...
Diversity supplement to P01CA240685 to characterize bromodomain proteins associated with endocrine therapy resistance in breast cancer
Gary Stein and Janet Stein, Program Directors Our Program Project is a thematically, experimentally and operationally integrated multidisciplinary team approach to address key comp...
Adapting Survivorship Care to Rural Practice, Translating Rural Evidence into Policy
Abstract In response to the widening rural-urban cancer mortality gap in the US, our parent research project aimed to improve access to comprehensive cancer care in rural communiti...
Predictors and Consequences of Nicotine and Cannabis Vaping Co-use in Young Adults: A Longitudinal and EMA Analysis
Co-use of both tobacco and cannabis products is common among young adults (ages 18-24), and recent data suggest that rates of co-use may be rising in line with changes in regulator...
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Understanding efficacy and FE(II)-Promoted Activation of 1,2,4-Trioxolanes in cancer
Project Summary/Abstract Summary: Precision cancer medicine’s foundation lies in discovering and exploiting pathways that are essential for cancer cells, but dispensable for cancer...
Stiff, solid microenvironments induce Chromosome loss and challenge Epigenetic therapies
ABSTRACT: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-24-029. Our proposed projectfacilitates a new collaboration...
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid Biopsy
PROJECT SUMMARY: Pancreatic ductal adenocarcinoma (PDA) will become the 2nd leading cause of cancer deaths in the United States by 2030. Most patients with PDA present with nonrese...
TRANSCRIPTIONAL REPROGRAMMING OF ESR1 MUTANT BREAST CANCER IN METASTASIS AND TREATMENT RESISTANCE
Project Summary Up to 1 in 8 women in the United States will develop invasive breast cancer in their lifetime, with 70-80% of cases being estrogen receptor positive (ER+). These ca...
Project 1: Mitotic Gene Bookmarking as an Epigenetic Mechanism to Maintain the Mammary Epithelial Phenotype
PROJECT 1 | SUMMARY Mechanisms underlying the epithelial to mesenchymal transition (EMT)—a normal developmental process and an early event at the onset of epithelium-derived cancer...
Exploring novel SRC-regulated pathways in IDH mutant intrahepatic cholangiocarcinoma
PROJECT SUMMARY/ABSTRACT Intrahepatic cholangiocarcinoma (ICC) is a highly lethal form of liver cancer which has been rising in incidence worldwide and carries a prognosis of under...
The Identity of the Notch Ankyrin Repeat Domain as a Determinant of Isoform-Specific Notch Signaling
Project Summary/Abstract: The Notch signaling pathway is a crucial regulator of development and cell differentiation in almost all animal organs and tissues. The Notch receptor is...
TRIM37 is a genetic determinant of racial disparity in metastatic TNBC patients
African American (AA) women presents with aggressive metastatic subtype of triple negative breast cancer (TNBC) compared to other ethnicities and experience greater mortality rates...
Synthetic epigenetic circuits: tunable cell fate switches controlled by dynamic and combinatorial inputs
PROJECT SUMMARY Cellular differentiation is controlled by epigenetic regulatory systems that integrate multiple sensory inputs over time to direct long-term cell fate decisions. Ha...