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20,252 grants found
Showing 18,141 – 18,160 of 20,252 grants
Developing a RPN13 inhibitor for the treatment of Quadruple Negative Breast Cancer
Quadruple negative breast cancer (QNBC), lacking the expression of ER (estrogen receptor), PR (progesterone receptor), HER2 (human epidermal growth factor receptor 2) and AR (andro...
Novel Radiomics for Predicting Response to Immunotherapy for Lung Cancer
ABSTRACT: In 2019, an estimated 228,150 patients in the US are expected to be diagnosed with non-small cell lung cancer (NSCLC). A recent landmark development has been the approval...
Novel Radiomics for Predicting Response to Immunotherapy for Lung Cancer
ABSTRACT: In 2019, an estimated 228,150 patients in the US are expected to be diagnosed with non-small cell lung cancer (NSCLC). A recent landmark development has been the approval...
Mitochondrial heterogeneity as the origin of chemoresistance in pancreatic cancer
Summary Therapeutic resistance and tumor relapse present as major barriers to achieving a definitive cure for cancer. This challenge is especially relevant for patients with pancre...
Team-based Interdisciplinary Cancer Research Training Program
TEAM-BASED INTERDISCIPLINARY CANCER RESEARCH TRAINING PROGRAM PROJECT SUMMARY/ABSTRACT In advancing innovative ways to address complex cancer challenges, there is a growing trend t...
Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma
Sarcomatoid renal cell carcinoma (sRCC) represents an aggressive group of renal epithelial tumors characterized by histopathological features of epithelial–mesenchymal plasticity (...
Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation
PROJECT SUMMARY/ABSTRACT The goal of this K08 Mentored Clinical Scientist Research Career Development Award is to prepare the candidate for an independent research career Breast ca...
Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem
PROJECT SUMMARY Ovarian cancer is a silent killer that strikes with few, if any, symptoms. By the time a woman knows she has it, the cancer is often advanced and the outlook grim....
Robot-Assisted Personalized Prostate Biopsy
PROJECT SUMMARY/ABSTRACT Prostate cancer (PCa) is the most commonly diagnosed type of cancer and the second leading cause of cancer related death among US men. The best current est...
Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences
Project Abstract Live cell reporters of genetic changes in stiff vs soft surroundings – causes & consequences Solid tumors are often palpably stiff and more constrained in 3D g...
Oligo(lactic acid)n-Prodrug Nanomedicines for Combination Therapy
Project Summary/Abstract Taxol is commonly used to treat TNBC and increasingly in combination with oral signal transduction inhibitors (STIs), such as mTOR inhibitor (Afinitor) a...
A Novel Microbiome-Based Immune-Modulator that Potentiates Cancer Checkpoint Therapy
Project Summary The goal of this project is to develop a novel oral drug, R-5780, which engages microbiome-associated Pattern Recognition Receptors (PRRs) to enhance the activity o...
Mechanisms of tumor initiation upon disruption of the Rb/E2f interaction
ABSTRACT E2f (E2f1-8) transcription factors are critical regulators of cell cycle and their activity is physically regulated by Rb family proteins (Rb, p107 and p130). Disruption o...
The Pediatric Advanced Cancer Experience (PACE): Measuring Quality of End-of-Life Care for Children with Cancer
PROJECT SUMMARY Although cure rates for childhood cancer have increased over several decades, cancer remains the leading cause of non-accidental death in children. Yet, there are n...
Novel Optimization Methods and Treatment Planning System for Clinically-Deliverable Truly-Hybrid Proton-Photon Radiotherapy
Project Summary Radiotherapy (RT) aims to deliver tumoricidal dose to clinical target volume (CTV) while sparing organs at risk (OAR), for which proton and photon beams are natural...
Optimizing Radiosynthetic Yield of [18F]FTT For Wide-Spread Distribution
ABSTRACT: Poly (ADP-ribose) polymerase inhibitors (PARPi’s) have emerged as important therapeutic agents targeting a broadening class of gene mutations approved for treatment of br...
Breast Cancer Intravoxel-incoherent-motion MRI Multisite (BRIMM) Study - Resubmission - 1
PROJECT SUMMARY While the technological enterprise of magnetic resonance imaging (MRI) generates a host of biomarkers of the tumor environment, in particular for breast cancer, pre...
Relaxed Polymerase Pausing as a Driver of Epigenetic Plasticity and Cancer Cell Invasion
Project Summary The development of distant metastases accounts for a significant proportion of breast cancer mortality; as many as 30% of patients initially diagnosed at an early s...
Mechanisms of metabolic stress-induced transcriptional regulation in prostate cancer
Metastatic prostate cancer (PCa) remains a major clinical challenge. Although androgen deprivation therapy (ADT) is effective in treating PCa, majority of the patients quickly deve...
Effectiveness and implementation of a health system intervention to improve quality of cancer care for rural, underserved patients
PROJECT SUMMARY There is growing evidence that limited access to high-quality cancer treatment is one of the main drivers of higher cancer mortality rates among rural cancer patien...