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Showing 18,10118,120 of 20,252 grants

Completed NON-SBIR/STTR RPGS
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2026

PROJECT ABSTRACT Previous randomized controlled trials (RCT)s demonstrate that low-dose aspirin (LDA, 81-100mg/day) reduces the risk of colorectal cancer (CRC). The U.S. Preventive...

$6.25M
USD
Completed NON-SBIR/STTR RPGS
Addressing racial disparities in lung cancer screening
NATIONAL CANCER INSTITUTE Vanderbilt University Medical Center United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Screening promotes early detection of cancer to decrease mortality. Unfortunately, significant racial disparities exist in lung cancer screening. Recently...

$10
USD
Completed NON-SBIR/STTR RPGS
Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHD
NATIONAL CANCER INSTITUTE Ohio State University United States 2021 – 2026

Abstract Acute Graft-versus-Host Disease (aGVHD) occurs due to donor T cell alloreactivity against host tissues and is the major cause of non-relapse mortality after allogeneic ste...

$3.94M
USD
Completed NON-SBIR/STTR RPGS
Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
NATIONAL CANCER INSTITUTE Cedars-Sinai Medical Center United States 2021 – 2026

PROJECT SUMMARY Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as...

$6.01M
USD
Completed NON-SBIR/STTR RPGS
Addressing racial disparities in lung cancer screening
NATIONAL CANCER INSTITUTE Vanderbilt University Medical Center United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Screening promotes early detection of cancer to decrease mortality. Unfortunately, significant racial disparities exist in lung cancer screening. Recently...

$5.47M
USD
Completed NON-SBIR/STTR RPGS
Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
NATIONAL CANCER INSTITUTE Cedars-Sinai Medical Center United States 2021 – 2026

PROJECT SUMMARY Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as...

$6.8M
USD
Completed NON-SBIR/STTR RPGS
Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHD
NATIONAL CANCER INSTITUTE Ohio State University United States 2021 – 2026

Abstract Acute Graft-versus-Host Disease (aGVHD) occurs due to donor T cell alloreactivity against host tissues and is the major cause of non-relapse mortality after allogeneic ste...

$4.15M
USD
Completed NON-SBIR/STTR RPGS
Addressing racial disparities in lung cancer screening
NATIONAL CANCER INSTITUTE Vanderbilt University Medical Center United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Screening promotes early detection of cancer to decrease mortality. Unfortunately, significant racial disparities exist in lung cancer screening. Recently...

$5.78M
USD
Completed NON-SBIR/STTR RPGS
Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2026

Abstract Cancer evolution constitutes a foremost obstacle to effective treatment, driving malignant cells to adapt and overcome therapy. Diffuse glioma illustrates the quandary of...

$5.47M
USD
Completed NON-SBIR/STTR RPGS
Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2026

Abstract Cancer evolution constitutes a foremost obstacle to effective treatment, driving malignant cells to adapt and overcome therapy. Diffuse glioma illustrates the quandary of...

$5.75M
USD
Completed NON-SBIR/STTR RPGS
Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
NATIONAL CANCER INSTITUTE Cedars-Sinai Medical Center United States 2021 – 2026

PROJECT SUMMARY Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as...

$6.94M
USD
Completed NON-SBIR/STTR RPGS
Addressing racial disparities in lung cancer screening
NATIONAL CANCER INSTITUTE Vanderbilt University Medical Center United States 2021 – 2025

PROJECT SUMMARY/ABSTRACT Screening promotes early detection of cancer to decrease mortality. Unfortunately, significant racial disparities exist in lung cancer screening.Recently p...

$6.59M
USD
Completed NON-SBIR/STTR RPGS
The Role of Implicit Bias on Outcomes of Patients with Advanced Solid Cancers
NATIONAL CANCER INSTITUTE Icahn School of Medicine At Mount Sinai United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT The outcomes of advanced solid cancer patients remain poor, particularly among minorities.Although patient- and system-level factors are important contribu...

$7.08M
USD
Completed NON-SBIR/STTR RPGS
Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHD
NATIONAL CANCER INSTITUTE Ohio State University United States 2021 – 2026

Abstract Acute Graft-versus-Host Disease (aGVHD) occurs due to donor T cell alloreactivity against host tissues and is the major cause of non-relapse mortality after allogeneic ste...

$4.15M
USD
Completed NON-SBIR/STTR RPGS
Development of Bone-Targeting Antibodies for Ewing Sarcoma Using Genetic Code Expansion
NATIONAL CANCER INSTITUTE Rice University United States 2021 – 2024

PROJECT SUMMARY/ABSTRACT Ewing sarcoma (ES) is the second most common pediatric bone cancer with peak incidence during the adolescent and young adult period. ES is an extremely agg...

$1.72M
USD
Completed NON-SBIR/STTR RPGS
Targeting epigenetic regulation via Bromodomain and Extraterminal (BET) domain inhibition for treatment of GVHD
NATIONAL CANCER INSTITUTE Ohio State University United States 2021 – 2026

Abstract Acute Graft-versus-Host Disease (aGVHD) occurs due to donor T cell alloreactivity against host tissues and is the major cause of non-relapse mortality after allogeneic ste...

$4.07M
USD
Completed NON-SBIR/STTR RPGS
Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics
NATIONAL CANCER INSTITUTE Massachusetts General Hospital United States 2021 – 2026

Abstract Cancer evolution constitutes a foremost obstacle to effective treatment, driving malignant cells to adapt and overcome therapy. Diffuse glioma illustrates the quandary of...

$5.47M
USD
Completed NON-SBIR/STTR RPGS
Randomized Controlled Trial of Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
NATIONAL CANCER INSTITUTE Cedars-Sinai Medical Center United States 2021 – 2026

PROJECT SUMMARY Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as...

$6.23M
USD
Completed NON-SBIR/STTR RPGS
Implications of metabolic heterogeneity on collective lung cancer cell invasion
NATIONAL CANCER INSTITUTE Emory University United States 2021 – 2026

Project Summary Most studies investigate whole cancer cell populations and rarely address how single cells or sub-populations cooperate to promote their survival and spread. This i...

$4.41M
USD
Completed NON-SBIR/STTR RPGS
Spatiotemporal interrogation of metabolic cooperation between heterogenous lung cancer subpopulations in collective cell invasion
NATIONAL CANCER INSTITUTE Emory University United States 2021 – 2026

PROJECT SUMMARY/ABSTRACT Not Requested

$663K
USD