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20,252 grants found
Showing 18,081 – 18,100 of 20,252 grants
P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality Disparities
PROJECT SUMMARY/ABSTRACT Genome stability is determined by multiple DNA repair pathways, including both error-prone and error-free mechanisms. Mutations can be caused by inactivati...
Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a soft tissue sarcoma, with one of the worst prognosis. We will build on our discovery that UPS contains a small subpopulation of meta...
Sustaining the Integrative Imaging Informatics for Cancer Research (I3CR) Center
Abstract Artificial intelligence (AI) and other computationally intensive methods have the potential to revolutionize cancer imaging research and patient care. The broad adoption o...
P53, DNA Repair Imbalance, and Immune Response in Breast Cancer Mortality Disparities
PROJECT SUMMARY/ABSTRACT Genome stability is determined by multiple DNA repair pathways, including both error-prone and error-free mechanisms. Mutations can be caused by inactivati...
Investigating the IL-1R Pathway in Anaplastic Large Cell Lymphoma for Targeted Therapy
PROJECT SUMMARY Anaplastic large cell lymphoma (ALCL) comprises a collection of mature T-cell neoplasms that share elevated expression of CD30 and anaplastic cytology. ALCL subtype...
Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) is a soft tissue sarcoma, with one of the worst prognosis. We will build on our discovery that UPS contains a small subpopulation of meta...
Sustaining the Integrative Imaging Informatics for Cancer Research (I3CR) Center
Abstract Artificial intelligence (AI) and other computationally intensive methods have the potential to revolutionize cancer imaging research and patient care. The broad adoption o...
Investigating the IL-1R Pathway in Anaplastic Large Cell Lymphoma for Targeted Therapy
PROJECT SUMMARY Anaplastic large cell lymphoma (ALCL) comprises a collection of mature T-cell neoplasms that share elevated expression of CD30 and anaplastic cytology. ALCL subtype...
NCI PATTERNS OF CARE (POC)/QUALITY OF CARE STUDY: DIAGNOSIS YEAR 2019 (URINARY BLADDER CANCER AND KIDNEY CANCER)
The primary objectives of the Fiscal Year 2021 NCI POC Study are to: 1) describe the use of recommended biomarker tests which shall be verified with the treating physician/physicia...
NCI PATTERNS OF CARE (POC)/QUALITY OF CARE STUDY: DIAGNOSIS YEAR 2019 (URINARY BLADDER CANCER AND KIDNEY CANCER)
The primary objectives of the Fiscal Year 2021 NCI POC Study are to: 1) describe the use of recommended biomarker tests which shall be verified with the treating physician/physicia...
Implications of metabolic heterogeneity on collective lung cancer cell invasion
Project Summary Most studies investigate whole cancer cell populations and rarely address how single cells or sub-populations cooperate to promote their survival and spread. This i...
Development of Bone-Targeting Antibodies for Ewing Sarcoma Using Genetic Code Expansion
PROJECT SUMMARY/ABSTRACT Ewing sarcoma (ES) is the second most common pediatric bone cancer with peak incidence during the adolescent and young adult period. ES is an extremely agg...
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.
PROJECT ABSTRACT Previous randomized controlled trials (RCT)s demonstrate that low-dose aspirin (LDA, 81-100mg/day) reduces the risk of colorectal cancer (CRC). The U.S. Preventive...
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancer
Project Summary Cancer is often thought of as a genetic disease. For example, specific protein-coding mutations can activate cancer-causing oncogenes. However, cancer-causing oncog...
Development of Bone-Targeting Antibodies for Ewing Sarcoma Using Genetic Code Expansion
PROJECT SUMMARY/ABSTRACT Ewing sarcoma (ES) is the second most common pediatric bone cancer with peak incidence during the adolescent and young adult period.ES is an extremely aggr...
Implications of metabolic heterogeneity on collective lung cancer cell invasion
Project Summary Most studies investigate whole cancer cell populations and rarely address how single cells or sub-populations cooperate to promote their survival and spread.This is...
Effects of inflammaging on intestinal epithelial cells and aspirin chemoprevention.
PROJECT ABSTRACT Previous randomized controlled trials (RCT)s demonstrate that low-dose aspirin (LDA, 81-100mg/day) reduces the risk of colorectal cancer (CRC). The U.S. Preventive...
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancer
Project Summary Cancer is often thought of as a genetic disease. For example, specific protein-coding mutations can activate cancer-causing oncogenes. However, cancer-causing oncog...
Transplanting Unique Human Microbiomes to Improve Immunotherapy in Glioblastoma
PROJECT SUMMARY Immune checkpoint inhibitors (ICI) have been successful in treating some, but not all, patients with melanoma brain metastases (MBM).Disappointingly, the same immun...
Super-resolution microscopy for dynamic analysis of focal enhancer amplifications in cancer
Project Summary Cancer is often thought of as a genetic disease. For example, specific protein-coding mutations can activate cancer-causing oncogenes. However, cancer-causing oncog...