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20,252 grants found
Showing 18,021 – 18,040 of 20,252 grants
Altered Lipid Metabolism in Luminal Breast Cancer Stem Cells and Endocrine Resistance
Project Summary/Abstract: Over two thirds of newly diagnosed breast cancer patients have estrogen receptor (ER) and progesterone receptor (PR) positive or "luminal" breas...
Identifying therapeutic options for intrahepatic cholangiocarcinoma
In the US, approximately 10,000 patients are newly diagnosed annually with cholangiocarcinoma, and their 5-yearsurvival rate is less than 10%. Heterogeneity in cellular origins and...
BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer
Project Summary Triple-Negative breast cancer (TNBC), which accounts for 15-20% of all breast cancer, represents an aggressive clinical history, development of distant metastasis,...
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers
Project Summary/Abstract Recently, it was found that the enzyme ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), the most common primary maligna...
Virtual Biopsy with Tissue-level Accuracy in Glioma
Project Summary This is a Bioengineering Research Grant (BRG) proposal in response to PAR-19-158 to further develop and validate a non-invasive panel of the most critical glioma mo...
Regulation of repetitive elements in cancer by P53 and epigenetic mechanisms
Despite focused research efforts, the five year survival for ovarian cancer (OC) has remained unchanged for decades and novel therapies are urgently needed for this deadly disease....
Regulation of repetitive elements in cancer by P53 and epigenetic mechanisms
Despite focused research efforts, the five year survival for ovarian cancer (OC) has remained unchanged for decades and novel therapies are urgently needed for this deadly disease....
Regulation of repetitive elements in cancer by P53 and epigenetic mechanisms
Despite focused research efforts, the five year survival for ovarian cancer (OC) has remained unchanged for decades and novel therapies are urgently needed for this deadly disease....
Regulation of repetitive elements in cancer by P53 and epigenetic mechanisms
Despite focused research efforts, the five year survival for ovarian cancer (OC) has remained unchanged for decades and novel therapies are urgently needed for this deadly disease....
Targeted degradation of proteins by affinity peptide conjugated ubiquitin (APCU)
Targeted degradation of proteins by affinity peptide conjugated ubiquitin (APCU) Protein degradation possesses many unique properties that cannot be covered by DNA/RNA manipulation...
FY21 CONSOLIDATED FACILITIES TASK ORDER B (NCI-OSFM-21-0056)
The purpose of this project is to renovate existing labs 12-19, 12-20, 12-25, and 12-34 at wing 1 floor 2 within building 560 to accommodate a new tissue culture lab and staff offi...
Exploratory clinical trial of topical Imiquimod 5% cream as window-of-opportunity monotherapy for early-stage oral cancer
PROJECT SUMMARY / ABSTRACT Each year an estimated 400,000 people globally, among them 30,000 Americans, are newly diagnosed with oral squamous cell carcinoma (OSCC).Of the newly di...
Defining epigenetic mechanisms in NPM1c mutant leukemia
Project Summary/Abstract Nucleophosmin (NPM1) mutations are among the most common aberrations in acute myeloid leukemia (AML) and cause a characteristic stem cell-like gene express...
Efficacy of an Electrophile Scavenger in the Prevention of Gastrointestinal Inflammatory Carcinogenesis
SUMMARY: Many cancers are recognized to have an inflammatory etiology.Gastric cancer, the third leading cause of cancer deaths worldwide, is the prototype- it is caused by infectio...
TISSUE CROSS-REACTIVITY STUDY OF A HUMAN ANTIBODY
The test agent is being considered for development as an anticancer therapeutic. The objective of this task was to obtain a source of tissue or cells for in vitro evaluations of to...
Defining epigenetic mechanisms in NPM1c mutant leukemia
Project Summary/Abstract Nucleophosmin (NPM1) mutations are among the most common aberrations in acute myeloid leukemia (AML) and cause a characteristic stem cell-like gene express...
Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy
SUMMARY The overarching goal of this new R01 application is to investigate the dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an establish...
Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy
SUMMARY - The overarching goal of this new R01 application is to investigate the dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an establi...
Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy
SUMMARY The overarching goal of this new R01 application is to investigate the dysregulation of mitochondrial networks responsible for maintaining normal metabolism is an establish...
Defining epigenetic mechanisms in NPM1c mutant leukemia
Project Summary/Abstract Nucleophosmin (NPM1) mutations are among the most common aberrations in acute myeloid leukemia (AML) and cause a characteristic stem cell-like gene express...