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20,252 grants found
Showing 18,001 – 18,020 of 20,252 grants
BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer
Project Summary Triple-Negative breast cancer (TNBC), which accounts for 15-20% of all breast cancer, represents an aggressive clinical history, development of distant metastasis,...
Functional mechanisms and therapeutic potential of EAG channel regulators
Ether-a-go-go (EAG) potassium selective channels are important regulators of neuronal excitability and cancer progression. Defects in EAG channel function are associated with neuro...
Clinical Development of First-in-Class Therapy for Metastatic Breast Cancer
We have developed a new therapeutic approach that relies on specific eradication of metastatic tumor cells through pharmacological inhibition of miRNA-10b. miR-10b is a master regu...
Identifying therapeutic options for intrahepatic cholangiocarcinoma
In the US, approximately 10,000 patients are newly diagnosed annually with cholangiocarcinoma, and their 5-yearsurvival rate is less than 10%. Heterogeneity in cellular origins and...
Functional mechanisms and therapeutic potential of EAG channel regulators
Ether-a-go-go (EAG) potassium selective channels are important regulators of neuronal excitability and cancer progression. Defects in EAG channel function are associated with neuro...
New treatment monitoring biomarkers for brain tumors using multiparametric MRI with machine learning
Project Summary/Abstract The goal of this project is to develop and evaluate novel imaging biomarker(s) that use multiparameter MRI methods to identify the true spatial extent of g...
Virtual Biopsy with Tissue-level Accuracy in Glioma
Project Summary This is a Bioengineering Research Grant (BRG) proposal in response to PAR-19-158 to further develop and validate a non-invasive panel of the most critical glioma mo...
Targeting Fanconi Anemia pathway to overcome platinum drug resistance in ovarian cancer
Project Summary Ovarian cancer (OC) is the fifth leading cause of cancer-related death among women and the deadliest gynecological cancer in the United States. The current standard...
Predictors and Consequences of Nicotine and Cannabis Vaping Co-use in Young Adults: A Longitudinal and EMA Analysis
Co-use of both tobacco and cannabis products is common among young adults (ages 18-24), and recent data suggest that rates of co-use may be rising in line with changes in regulator...
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers
Project Summary/Abstract Recently, it was found that the enzyme ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), the most common primary maligna...
BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer
Project Summary Triple-Negative breast cancer (TNBC), which accounts for 15-20% of all breast cancer, represents an aggressive clinical history, development of distant metastasis,...
Identifying therapeutic options for intrahepatic cholangiocarcinoma
In the US, approximately 10,000 patients are newly diagnosed annually with cholangiocarcinoma, and their 5-yearsurvival rate is less than 10%. Heterogeneity in cellular origins and...
Targeting Fanconi Anemia pathway to overcome platinum drug resistance in ovarian cancer
Project Summary Ovarian cancer (OC) is the fifth leading cause of cancer-related death among women and the deadliest gynecological cancer in the United States. The current standard...
Virtual Biopsy with Tissue-level Accuracy in Glioma
Project Summary This is a Bioengineering Research Grant (BRG) proposal in response to PAR-19-158 to further develop and validate a non-invasive panel of the most critical glioma mo...
Functional mechanisms and therapeutic potential of EAG channel regulators
Ether-a-go-go (EAG) potassium selective channels are important regulators of neuronal excitability and cancer progression. Defects in EAG channel function are associated with neuro...
BBOX1 is a Novel Oncogenic Driver in Triple Negative Breast Cancer
Project Summary Triple-Negative breast cancer (TNBC), which accounts for 15-20% of all breast cancer, represents an aggressive clinical history, development of distant metastasis,...
Altered Lipid Metabolism in Luminal Breast Cancer Stem Cells and Endocrine Resistance
Project Summary/Abstract: Over two thirds of newly diagnosed breast cancer patients have estrogen receptor (ER) and progesterone receptor (PR) positive or luminal breast cancer.End...
Predictors and Consequences of Nicotine and Cannabis Vaping Co-use in Young Adults: A Longitudinal and EMA Analysis
Co-use of both tobacco and cannabis products is common among young adults (ages 18-24), and recent data suggest that rates of co-use may be rising in line with changes in regulator...
Virtual Biopsy with Tissue-level Accuracy in Glioma
Project Summary This is a Bioengineering Research Grant (BRG) proposal in response to PAR-19-158 to further develop and validate a non-invasive panel of the most critical glioma mo...
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers
Project Summary/Abstract Recently, it was found that the enzyme ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), the most common primary maligna...