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20,252 grants found
Showing 17,981 – 18,000 of 20,252 grants
Targeting Fanconi Anemia pathway to overcome platinum drug resistance in ovarian cancer
Project Summary Ovarian cancer (OC) is the fifth leading cause of cancer-related death among women and the deadliest gynecological cancer in the United States. The current standard...
Functional mechanisms and therapeutic potential of EAG channel regulators
Ether-a-go-go (EAG) potassium selective channels are important regulators of neuronal excitability and cancer progression. Defects in EAG channel function are associated with neuro...
The Role of Transcription Factors in Driving Aggressive Phenotype in Non-Invasive Bladder Cancer
Project summary Bladder cancer is most commonly diagnosed at an early stage, where it has not invaded into the bladder wall or has done so minimally. Treatment is resection of the...
Using Natural Language Processing and Crowdsourcing to Monitor and Evaluate Public Information and Communication Disparities about Colon Cancer Screening
PROJECT SUMMARY Colorectal cancer (CRC) incidence and death rates are higher among Black Americans than non-Hispanic White Americans. While some CRC-related disparities have decrea...
Non-invasive Transcranial Histotripsy Treatment in a Murine Primary Malignant Brain Tumor Model
Title: Non-invasive Transcranial Histotripsy Treatment in a Murine Primary Malignant Brain Tumor Model Abstract The goal of this proposal is to investigate whether transcranial his...
New treatment monitoring biomarkers for brain tumors using multiparametric MRI with machine learning
Project Summary/Abstract The goal of this project is to develop and evaluate novel imaging biomarker(s) that use multiparameter MRI methods to identify the true spatial extent of g...
Clinical Development of First-in-Class Therapy for Metastatic Breast Cancer
We have developed a new therapeutic approach that relies on specific eradication of metastatic tumor cells through pharmacological inhibition of miRNA-10b. miR-10b is a master regu...
Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers
Project Summary/Abstract Recently, it was found that the enzyme ornithine aminotransferase (OAT) is overexpressed in hepatocellular carcinoma (HCC), the most common primary maligna...
Clinical Development of First-in-Class Therapy for Metastatic Breast Cancer
We have developed a new therapeutic approach that relies on specific eradication of metastatic tumor cells through pharmacological inhibition of miRNA-10b. miR-10b is a master regu...
Using Natural Language Processing and Crowdsourcing to Monitor and Evaluate Public Information and Communication Disparities about Colon Cancer Screening
PROJECT SUMMARY Colorectal cancer (CRC) incidence and death rates are higher among Black Americans than non-Hispanic White Americans. While some CRC-related disparities have decrea...
Using Natural Language Processing and Crowdsourcing to Monitor and Evaluate Public Information and Communication Disparities about Colon Cancer Screening
PROJECT SUMMARY Colorectal cancer (CRC) incidence and death rates are higher among Black Americans than non-Hispanic White Americans.While some CRC-related disparities have decreas...
Targeting BUB 1 for radio- and immuno-sensitization of Triple Negative Breast Cancer (TNBC)
PROJECT SUMMARY-ABSTRACT Background: Breast cancer is the number one killer of women between the ages of 44 and 55 in this country.It is estimated that more than 276,480 women will...
Predictors and Consequences of Nicotine and Cannabis Vaping Co-use in Young Adults: A Longitudinal and EMA Analysis
Co-use of both tobacco and cannabis products is common among young adults (ages 18-24), and recent data suggest that rates of co-use may be rising in line with changes in regulator...
Targeting Fanconi Anemia pathway to overcome platinum drug resistance in ovarian cancer
Project Summary Ovarian cancer (OC) is the fifth leading cause of cancer-related death among women and the deadliest gynecological cancer in the United States. The current standard...
Sex-dependent rescue of cancer cachexia
PROJECT SUMMARY Cachexia is a multi-factorial syndrome accompanying cancer, with the most notable symptom being unintentional weight loss due to a depletion of skeletal muscle and...
Identifying therapeutic options for intrahepatic cholangiocarcinoma
In the US, approximately 10,000 patients are newly diagnosed annually with cholangiocarcinoma, and their 5-year survival rate is less than 10%.Heterogeneity in cellular origins and...
Development of a Theranostic Nanomedicine Construct for Ovarian Cancer
RELEVANCE: Ovarian cancer is the fifth leading cause of cancer-related deaths for women in the United States.While ovarian cancer patients initially respond to current treatment op...
New treatment monitoring biomarkers for brain tumors using multiparametric MRI with machine learning
Project Summary/Abstract The goal of this project is to develop and evaluate novel imaging biomarker(s) that use multiparameter MRI methods to identify the true spatial extent of g...
New treatment monitoring biomarkers for brain tumors using multiparametric MRI with machine learning
Project Summary/Abstract The goal of this project is to develop and evaluate novel imaging biomarker(s) that use multiparameter MRI methods to identify the true spatial extent of g...
Disruption of Type I Interferon Induction by a KSHV Homologue of IPS-1
Project Abstract Herpes infections represent one of the most common viral infections that exists in the world.These viruses can be subclinical or as in the case of Kaposi?s Sarcoma...