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20,252 grants found
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Hybrid Trial of a Tailored Smoking Cessation Digital Therapeutic for Persons Living with HIV
PROJECT ABSTRACT Tobacco use has alarmingly high rates among people with HIV (PWH), 43% compared with 15% in the general population. Due to the development of highly effective trea...
Precision targeting of bladder cancer using CRISPR
ABSTRACT Chromosome rearrangements (structural variants) are common in cancer and they drive tumor development by altering the expression or function of oncogenes and tumor suppres...
Identification of cancer neoepitope-specific T cells using novel high-throughput hydrogel based platforms
Abstract Immunotherapies for cancer, including Adoptive Cell Transfer (ACT), chimeric antigen receptor (CAR) T cell therapy, and Immune Checkpoint Blockade (ICB), have seen great c...
Enabling in vivo barcoded single-cell multiomics-compatible genome-wide screens in personalized tumor models using defined-copy somatic transgenesis
PROJECT SUMMARY / ABSTRACT CRISPR technology have massively expanded our ability to interrogate the genetic mechanisms of cancer and define therapeutic avenues. Techniques have evo...
Contributions of the Adipose Tissue to the Development of Pancreatic Cancer
Project Summary Obesity is a risk factor for pancreatic ductal adenocarcinoma (PDAC), a cancer that has a dismal 5-year survival rate due to limitations in prevention and treatment...
Novel functions of ESRRB in glioblastoma
Glioblastoma (GBM) is the most lethal of all brain malignancies and many patients die within one year of diagnosis. These poor outcomes are driven by GBM's aggressive growth,...
Enhancing motivation to quit smoking via self-help intervention targeted to cancer type: A pilot RCT
Project Summary/Abstract Tobacco smoking is causally related to at least 12 cancer types. Quitting smoking after cancer is critical for improved treatment outcomes; however, over t...
Treatment Planning System for Electron FLASH radiation therapy
Abstract Ultra-high dose rate (UHDR) radiation delivery, termed FLASH radiotherapy (FLASH-RT), has the potential to reduce normal tissue damage, with significant clinical cancer tr...
Genomic lineage traces as biomarkers for human pancreatic and liver cancer
PROJECT SUMMARY While cancer is known for its heterogeneity, with distinct subtypes observed within each organ system, the source of this heterogeneity, and the relationship betwee...
A novel role for EZH2 in A-to-I RNA editing in prostate cancer
Abstract Prostate cancer is one of the most common cancers among men, and although it can successfully be treated in some men, others develop resistance to therapies and can relaps...
Therapeutic Cancer NanoVaccine Promotes B/CD 4 T Cell Crosstalk for Durable Anticancer Efficacy
ABSTRACT Current cancer therapeutic vaccines that utilize both CD4 and CD8 T cell neoantigens to stimulate T cell immunity through dendritic cell/macrophage-mediated antigen presen...
Solid Phase Microextraction as a New Tool for Quantifying Antibody Drugs in Breast Cancer and Building PK-PD models
Modern drug analysis techniques are an integral part of research and healthcare today. Regrettably, the current approach for sample collection consists of literally removing “a pie...
Merkel cell polyomavirus T-Antigen mediated reprogramming in adult epidermis
ABSTRACT Merkel cell carcinoma (MCC) is a poorly understood cutaneous malignancy with viral etiology. Most MCC tumors feature monoclonal integration of Merkel cell polyomavirus (MC...
Discovery of SATB2 Inhibitors for Pancreatic Cancer
Abstract Pancreatic cancer is a slow-growing disease with a 5-year survival rate of approximately 9%. It is the fourth leading cause of cancer-related deaths in the US. Currently u...
CAR mast cell for solid tumor
Summary Chimeric Antigen Receptor (CAR)-T cell therapies have achieved unprecedented success in treating blood cancers that are resistant to traditional radiation or chemotherapies...
Targeting phenethyl isothiocyanate to mitochondria in lung carcinogenesis
Project Summary Disruption of normal mitochondrial bioenergetics and oxidative phosphorylation represents an early event during oncogenesis by changing the energy metabolism of pre...
CAR T Cells for Advanced Thyroid Cancer
Project Summary The overall incidence of thyroid cancer in 2016 was estimated by the National Cancer Institute to be 64,300. Patients who present with poorly differentiated thyroid...
T cell-intrinsic metabolic control of radiotherapy
PROJECT SUMMARY/ABSTRACT Unprecedented clinical successes in past 12-years with immune checkpoint blockers (ICBs) such as anti- CTLA-4 and anti-PD-1 re-instigate strong interests i...
Investigating mechanisms of CARD11 mutants in enhanced anti-tumor immunity and T cell fitness (For Kathleen Cheng)
Project Summary/Abstract Adoptive cellular therapies (ACTs) have made remarkable advances in the treatment of hematological malignancies. However, remarkable outcomes are confined...
Identifying the role of the gut microbiome in the etiology of benign breast disease
PROJECT SUMMARY/ABSTRACT The overall goal of this project is to identify the role of the gut microbiome in the etiology of benign breast disease (BBD), and thereby shed light on it...