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20,252 grants found
Showing 161 – 180 of 20,252 grants
Defining brain-body feedback loops mediating stress-induced metastasis
Evidence from human epidemiological studies and animal models reveals that chronic psychological stress influences the evolution, dissemination, and treatment results of neoplasia....
Targeting minimal residual disease in AML by using single-cell morphological and biophysical analysis with deep learning
Summary Conventional chemotherapy regimens induce complete remission in the majority of patients with acute myeloid leukemia (AML) and results in >95% reduction in tumor burden....
Dual-targeted DOTA CAR T cells with image-guided monitoring for solid tumor treatment
Abstract CAR T cells can mediate deep, durable cancer remissions but their activity is not controllable once infused, they are not easily tracked, their risk for toxicity remains a...
A novel approach for treating myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML)
Abstract Patients diagnosed with myelodysplastic syndrome (MDS) face a challenging treatment landscape, with limited options consisting mainly of blood transfusions and hypomethyla...
Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)
PROJECT SUMMARY – OVERALL Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a rising cause of cancer mortality. HCC related to metabolic stress is on the r...
Core A: Administrative Core
PROJECT SUMMARY – CORE A: ADMINISTRATIVE The Administrative Core A, directed by Dr. Kaufman is an essential component of this Program Project, providing logistic and strategic supp...
Project 1: Control of NASH to HCC progression by the NRF2-FBP1 tug-of-war
PROJECT SUMMARY – PROJECT 1 Project 1 is striving to understand the role of transcription factor NRF2 and the gluconeogenic enzyme fructose bisphosphate phosphatase 1 (FBP1) in NAS...
Project 2: The UPR transducer ATF6 drives HCC in response to metabolic stress
PROJECT SUMMARY -PROJECT 2 Hepatocellular carcinoma is (HCC) is the most common primary liver cancer and 3rd leading cause of cancer deaths worldwide. HCC etiology is rapidly chang...
Project 3: Metabolic stress induces mitochondrial dysfunction through STARD1 and SAB leading to HCC
PROJECT SUMMARY – PROJECT 3 The incidence of NASH-driven HCC is expected to increase worldwide due to its association with the obesity and type-2 diabetes epidemic. Chronic ER stre...
Core 1: Metabolomics
PROJECT SUMMARY – CORE 1 The liver is of central importance to whole-body metabolism, with major roles, among others, in glucose and fatty acid metabolism, and cholesterol and bile...
Core 2: Bioinformatics/Biostatistics/Genomics
CORE 2 PROJECT SUMMARY Key to this proposal is the inclusion of Core 2, which encompasses unified support for Bioinformatics, Biostatistics, Genomics, Transcriptomics, and Computat...
Evaluation of Commercial Mammography-Based Artificial Intelligence Algorithms for Breast Cancer Risk Prediction in U.S. Screening Populations
PROJECT SUMMARY Women known to be at high risk for breast cancer have opportunities to reduce their risk through primary and secondary breast cancer prevention, including risk-redu...
Conmigo: a multi-level mother-daughter physical activity intervention for pre-adolescent Latinas
ABSTRACT Fewer US Latina girls meet current physical activity (PA) guidelines, with lower rates observed among those from lower-income and less-acculturated backgrounds, contributi...
Social media support groups for adolescent vaping cessation
ABSTRACT Tobacco use causes one third of cancer-related mortality. Decades of tobacco control progress are threatened by the promotion and popularity of e-cigarettes (colloquially...
TLR Agonist Nano-Immune Therapy for Peritoneal Metastases
Summary Peritoneal metastases are present at diagnosis in 57% of women with ovarian cancer and 8% of patients with colorectal cancer. Peritoneal metastases have been considered a t...
Next Generation Immunotherapies for Pediatric Cancers
PROJECT SUMMARY Since the 1990s, pediatric oncology has made sustained strides in understanding the biology that drives children’s cancers, but these understandings have not yielde...
Defining the role of the mitochondrial protein, GOT2, in pancreatic cancer metastasis and epigenetic dysregulation
Project Summary Pancreatic adenocarcinoma (PDAC) is a highly aggressive and deadly form of pancreatic cancer with a poor prognosis and low survival rate. Despite advances in treatm...
Late-stage development and de-risking of a novel monoclonal antibody immunotherapy for EGFR-positive solid cancers
Abstract The primary objective of this project is to develop therapeutic IgA to uniquely harness the tumor cytolytic potential of neutrophils to target EGFR-mutant non-small cell l...
ATUSA: World's First Wearable and Automated 3D Breast Ultrasound System with AI
PROJECT SUMMARY Breast cancer (BC) is a formidable global health challenge, affecting millions of women worldwide annually. This malignancy is a leading cause of death among women,...
Advancing Cancer Control Equity Research Through Transformative Solutions in Patient Navigation (ACCERT PN)
OVERALL – ABSTRACT Chicago, one of the most diverse yet segregated cities in the US, is characterized by egregious cancer health inequities. We propose to establish the Advancing C...