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20,252 grants found
Showing 17,941 – 17,960 of 20,252 grants
Role of ALDH in PARP inhibitor resistance in HR-deficient ovarian cancer
Summary Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are an exciting and promising new class of anticancer drugs, which have been approved by the FDA for recurrent ovaria...
Metabolic Regulation of the Epigenetic Landscape in T cell Exhaustion
ABSTRACT/PROJECT SUMMARY My overarching goal is to understand the regulation of the metabolism-epigenetic axis in cancer and cancer associated pathologies. T cell exhaustion (Tex)...
Metabolic Regulation of the Epigenetic Landscape in T cell Exhaustion
ABSTRACT/PROJECT SUMMARY My overarching goal is to understand the regulation of the metabolism-epigenetic axis in cancer and cancer associated pathologies. T cell exhaustion (Tex)...
CORE INFRASTRUCTURE TASK ORDER FOR CISNET CONSORTIUM FOR CANCER SURVEILLANCE MODELING SUPPORT
The Contractor shall work with the National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS) to provide technical and logistical support to facili...
CORE INFRASTRUCTURE TASK ORDER FOR CISNET CONSORTIUM FOR CANCER SURVEILLANCE MODELING SUPPORT
The Contractor shall work with the National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS) to provide technical and logistical support to facili...
CORE INFRASTRUCTURE TASK ORDER FOR CISNET CONSORTIUM FOR CANCER SURVEILLANCE MODELING SUPPORT
The Contractor shall work with the National Cancer Institute (NCI), Division of Cancer Control and Population Sciences (DCCPS) to provide technical and logistical support to facili...
Ultrahigh-Resolution Quantitative Optical Coherence Elastography of the Tumor Microenvironment In Vivo
The understanding of cancer has evolved rapidly over the last decade.One of the key findings is that altered mechanical properties is not just a symptom of tumors, but can trigger...
CAR T Cells for Advanced Thyroid Cancer
Project Summary The overall incidence of thyroid cancer in 2016 was estimated by the National Cancer Institute to be 64,300.Patients who present with poorly differentiated thyroid...
CAR T Cells for Advanced Thyroid Cancer
Project Summary The overall incidence of thyroid cancer in 2016 was estimated by the National Cancer Institute to be 64,300. Patients who present with poorly differentiated thyroid...
CAR T Cells for Advanced Thyroid Cancer
Project Summary The overall incidence of thyroid cancer in 2016 was estimated by the National Cancer Institute to be 64,300. Patients who present with poorly differentiated thyroid...
Identification of serum protein biomarkers by profiling N-glycoproteomes of patient-derived xenografts of clear cell renal cell carcinoma
PROJECT SUMMARY Postoperative surveillance (PS) by medical imaging is critical for the management of clear cell renal cell carcinoma (ccRCC) patients.However, it is expensive and l...
Translational control of EMT by the CELF1 RNA Binding Protein
By some estimates, tumor metastasis is responsible for over 90% of cancer mortality. At the cellular level, epithelial to mesenchymal transition (EMT) is the initiating event in tu...
Development of Standardized Electronic Treatment Plan Builds for NCI-Supported Clinical Trials at the University of Iowa Holden Comprehensive Cancer Center
Abstract: The overall goal of this project is unchanged.It is for the Holden Comprehensive Cancer Center (HCCC) to collaborate with the Big Ten Electronic Health Record Consortium...
Myeloid Malignancy Variant Curation Expert Panel
Germline predisposition to hematopoietic malignancies is more common than previously appreciated and is best understood currently for the myeloid malignancies. Variants in genes su...
Development of a Therapeutic Monoclonal Antibody Against EGFL6, a Mediator of Tumor Growth and Metastasis
SUMMARY A diagnosis of ovarian cancer (OvCa) is especially devastating.With 22,240 diagnoses in 2018 and an estimated 14,070 deaths, OvCa has the third-highest mortality rate, lead...
Myeloid Malignancy Variant Curation Expert Panel
Germline predisposition to hematopoietic malignancies is more common than previously appreciated and is best understood currently for the myeloid malignancies.Variants in genes suc...
Myeloid Malignancy Variant Curation Expert Panel
Project Summary Germline predisposition to hematopoietic malignancies is more common than previously appreciated and is best understood for the myeloid malignancies. Variants in ge...
Myeloid Malignancy Variant Curation Expert Panel
Germline predisposition to hematopoietic malignancies is more common than previously appreciated and is best understood currently for the myeloid malignancies. Variants in genes su...
Myeloid Malignancy Variant Curation
Germline predisposition to hematopoietic malignancies is more common than previously appreciated and is best understood currently for the myeloid malignancies. Variants in genes su...
Mechanisms Of Akt Regulation
Abstract: The Ser/Thr protein kinase Akt1 is key signaling enzyme that participates in the regulation of cell growth and other physiologic processes, and its dysregulation contribu...